Objective To investigate the efficacy and safety of acyclovir eye drops combined with glucocorti -coid in the treatment of severe viral keratitis .Methods 92 patients with severe viral keratitis were enrolled in this study.The patients were divided into control group and observation group according to random number table , with 46 cases in each group .The control group was treated with acyclovir eye drops ,and the observation group was treated with glucocorticoid combined with acyclovir eye drops .The clinical efficacy ,visual acuity ,adverse reactions and recur-rence of keratitis were compared and analyzed in the two groups .Results The total effective rate of the observation group was 95.65%,which was significantly higher than 67.39% of the control group,the difference was statistically significant (χ2 =12.195,P<0.05).After treatment,the visual acuity in the observation group was (0.87 ±0.31), which was significantly higher than (0.65 ±0.27) in the control group,the difference was statistically significant (t=3.630,P<0.05).The recurrence rate of the observation group was 4.35%,which was significantly lower than 21.74%of the control group (χ2 =6.133,P<0.05).The incidence rate of adverse reactions between the two groups had no statistically significant difference (P>0.05).Conclusion Acyclovir eye drops combined with glucocorticoid in the treatment of severe viral keratitis has significant treatment effect ,it can effectively improve the visual acuity of patients,reduce the recurrence rate ,improve the treatment effect ,and with high safety .

Objective: To investigate the clinical value of modified glaucoma combined with cataract surgery in the treatment of chronic angle closure glaucoma with cataract. Methods: From May 2012 to August 2017, 350 patients with chronic angle closure glaucoma complicated with cataract in the Second Hospital of Shaoxing were studied.According to the difference of treatment methods, they were divided into two groups, with 175 cases in each group.The control group was treated with trabeculectomy, the observation group was treated with modified glaucoma combined with cataract surgery.The intraocular pressure (IOP), visual acuity were observed. Results: The IOP values of the observation group were (22.50±1.48)mmHg, (18.77±2.38)mmHg, (14.21±0.93)mmHg at 3 d, one month and three months after operation, which were significantly lower than those of the control group [(28.91±2.05)mmHg, (23.28±2.49)mmHg, (17.75±1.16)mmHg], the differences were statistically significant(t=33.54, 17.32, 31.50, all P<0.05). Three months after operation, the depth of central anterior chamber in the observation group was (3.21±0.51)mm, which was obviously higher than that in the control group [(2.90±0.77)mm], the difference was statistically significant (t=4.44, P<0.05). The visual acuity index of the observation group was better than that of the control group (P<0.05). There was no statistically significant difference in the incidence of adverse events between the two groups (1.14% vs.4.00%, χ²=2.85, P>0.05). Conclusion The modified glaucoma combined with cataract surgery is effective in the treatment of chronic angle closure glaucoma with cataract, and can significantly improve the IOP and visual acuity.And the safety is high.