CT and TT genotype frequencies of TNF-? gene at -857 site in obese patients with type 2 diabetes mellitus (DM)andcontrolgroupswithoutobesity were 0.396, 0.020 and 0.179, 0.000, and T allele 0.220 and 0.090, respectively. This finding suggests that mutation is associated with type 2 DM in obese subjects.

Objective:To investigate the dyadic coping and negative emotional of patients with cervical spinal stenosis accompanied by incomplete paralysis and their spouses, and analyze the differences between the patients and their spouses.Methods:From January 2019 to January 2021, purposive sampling was used to select 120 patients with cervical spinal stenosis accompanied by incomplete paralysis and their spouses who were hospitalized in the Department of Orthopedics of Nanjing First Hospital, Nanjing Medical University (Nanjing First Hospital) as the study subject. The Dyadic Coping Inventory and the Hospital Anxiety and Depression Scale were used to evaluate the dyadic coping, anxiety, and depression of patients and their spouses, respectively.Results:The total score of the Dyadic Coping Inventory for patients with cervical spinal stenosis and incomplete paralysis, as well as the item average scores of pressure communication, support dyadic coping, agency dyadic coping, common dyadic coping, and negative dyadic coping dimensions, were (107.28±17.35), (1.21±0.38), (1.39±0.67), (1.46±0.33), (1.21±0.48), and (3.88±0.75), respectively. The spouse's scores were (108.22±16.54), (1.34±0.69), (1.85±0.49), (1.57±0.61), (1.93±0.43), and (2.85±0.61), respectively. There were statistically significant differences in scores between patients and their spouses in support dyadic coping, common dyadic coping, and negative dyadic coping dimensions ( P<0.05), while there was no statistically significant difference in total scores and other dimensions ( P>0.05). In the survey of patients' dyadic coping level, 62 cases (51.7%, 62/120) were at low level, 34 cases (28.3%, 34/120) were at medium level, and 24 cases (20.0%, 24/120) were at high level. Among the spouses of patients, 58 (48.3%, 58/120) were at low level, 36 (30.0%, 36/120) were at medium level, and 26 (21.7%, 26/120) were at high level. There was no statistically significant difference in the proportion of low, medium and high levels between patients and their spouses ( P>0.05). The anxiety subscale score of patients with cervical spinal stenosis and incomplete paralysis was (18.79±3.93), the depression subscale score was (18.95±4.82), and the total score of the Hospital Anxiety and Depression Scale was (39.27±4.21). The anxiety score of the patient's spouse was (19.13±2.68), the depression score was (19.22±4.03), and the total score was (40.04±4.77). There was no statistically significant difference in anxiety, depression, and total scores between patients and their spouses ( P>0.05) . Conclusions:Patients with cervical spinal stenosis accompanied by incomplete paralysis and their spouses have low levels of positive dyadic coping, high levels of negative dyadic coping, and widespread negative emotions such as anxiety and depression. Nurses should pay attention to the important role of spouses in the diagnosis, treatment, and rehabilitation of patients with cervical spinal stenosis and incomplete paralysis, and provide scientific psychological intervention to patients and their families together.

Objective:To explore the clinical effect of moderate exercise therapy and fracture liaison service in osteoporotic hip fracture.Methods:From June 2018 to June 2020, 120 patients with osteoporotic hip fracture admitted to Nanjing Hospital Affiliated to Nanjing Medical University were selected. The patients were divided into study group and control group by random number table method, 60 cases in each group. The control group was treated with routine nursing and moderate exercise therapy, and the control group was treated with fracture liaison service, clinical observation and comparison of treatment compliance, bone mineral density (BMD), Numerical Rating Scale (NRS) score and nursing satisfaction before and after intervention.Results:The BMD and NRS scores in the study group were (0.90±0.25) g/cm 2, (1.0±0.3) points, higher than those in the control group (0.80±0.18) g/cm 2, (1.0±0.25) points. The difference was statistically significant ( t values were 2.514, 2.547, P<0.05). The total compliance rate and nursing satisfaction of the study group were 93.30% (56/60) and 95.00% (57/60) respectively, which were significantly higher than 80.00% (48/60) and 83.33% (50/60) of the control group. The difference was statistically significant ( χ 2 values were 4.615, 4.227, P<0.05). Conclusion:Moderate exercise therapy and fracture contact service intervention can effectively improve bone mineral density and total compliance rate, relieve pain and improve nursing satisfaction.

OBJECTIVE: To explore the prevalence and clinical manifestations of ring chromosomes among children featuring abnormal development. METHODS: From January 2015 to August 2021, 7574 children referred for abnormal development were selected, and their peripheral blood samples were subjected to G-banded chromosomal karyotyping analysis. RESULTS: Twelve cases of ring chromosomes were detected, which have yielded a prevalence of 0.16% and included 1 r(6), 2 r(9), 1 r(13), 1 r(14), 2 r(15), 1 r(21) and 3 r(X). The children had various clinical manifestations including growth and mental retardation, limb malformation, and congenital heart disease. For two children with r(9) and two with r(15) with similar breakpoints, one child with r(9) and one with r(15) only had growth retardation, whilst another with r(9) and another with r(15) also had peculiar facies and complex congenital heart disease. The r(X) has featured some manifestations of Turner syndrome. CONCLUSION Ring chromosomes are among the common causes for severe growth and mental retardation in children with diverse clinical phenotypes. Clinicians should pay attention to those with developmental anomalies and use chromosomal analysis to elucidate their genetic etiology.
Humans ; Ring Chromosomes ; Intellectual Disability/genetics* ; Turner Syndrome/genetics* ; Phenotype ; Heart Defects, Congenital/genetics*

Objective To explore the relationship between chromosomal abnormalities and diseases in children by analyzing chromosome karyotypes. Methods The chromosome karyotype analysis of peripheral lymphocytes in 5 329 children was performed. Results In all, abnormal karyotype were found in 1 723 cases (32.33％) , in which the numerical chromosome abnormalities were detected in 1 539 (89.32％) , following by 125 cases of structural chromosome abnormalities (7.25％) , 53 cases of sex reverse syndrome (3.08％) , and 6 cases of true hermaphroditism (0.35％). The chromosome polymorphism were detected in 228 cases (4.28％). Conclusions The numerical chromosome abnormalities is most frequent chromosomal aberration and is one of the important causes that result in mental retardation, growth delay and disorders of sex development in children.