Objective To investigate clinical features and the early recurrence factors of watershed infarction(WSI).Methods Two hundred and eighty-three patients with acute anterior circulation vascular infraction confirmed by CT or MRI were collected in Heilongjiang Province Hospital from January 2010 to December 2012.Patients' information including gender,sex,risk factors for stroke and vascular stenosis was colleced.Patients were divided into the lacunar infarction group (n =83),large infarction group(n =60) and the WSI group (n =140).All patients were followed up for 6 months to observe cerebral infarction recurrence status.The national institutes of health stroke scale(NIHSS) test of all patients was performed.Meanwhile the information including disease stage was collected and analysed.Results (1) The recurrent rate in WSI group,large infarction group and lacunar infarction group were 40.0％ (56/140),30.0％ (18/60),9.6％ (8/83)respectively.The difference between recurrent rate and lacunar infarction group was statistically significant(x2 =23.5,x2 =9.7,P ＜ 0.05),and the recurrent rate of WSI was highest.(2)The symptoms of patients with WSI were relatively mild in most patients after the initial stroke.75.7％ (106/140)WSI patients were 0-4 points regarding of NIHSS score,22.9％ (32/140) for 5-9 points and only 1.4％ (2/140) for more than 10 points.The clinical symptoms aggravated obviously in recurrent WSI patients.Of recurrent patients,28.6％ (16/56) were with high NIHSS score (score ≥ 10 points).(3)The difference between recurrent group and unrecurrent group in terms of unstable plaque,baseline systolic blood pressure,degree of stenosis ≥ 70％ was statistically significant(P ＜ 0.05).Conclusion The recurrent rate is higher in WSI group than other infarction type.The clinical symptoms are relatively mild in most of the WSI patients after the initial stroke,but the symptoms turn serious when stoke recurrent and the prognosis is poor.The unstable plaque,baseline systolic blood pressure,degree of stenosis ≥ 70％ may be the risk factors of stroke recurrence.

From information and consent,the article explores the history,connotation,element and the problems encountered in practice of informed consent.The paper aims to provide help for resolving realitical problems by these theoretical discussion.

OBJECTIVE To study the cell-mediated immune function among older inpatients with Pseudomonas aeruginosa pneumonia.METHODS T-cell subsets and expression of membrane molecule on activated T-cell in peripheral blood were measured in 35 cases with P.aeruginosa pneumonia by using immunofluorescence and flow cytometry,and compared with those of control healthy older people.RESULTS The expressions of CD4+ /CD3+ and CD25+ /CD3+ in P.aeruginosa pneumonia patients were lower than in control group(P0.05).CONCLUSIONS There are disfunctions of lymphocgte and immunity among P.aeruginosa pneumonia patients.

Objective To explore the application of a comprehensive assessment method to sanitary management of public places. Methods Sanitary management of public places from 1996 to 2000 in Tongzhou was assessed using a comprehensive coefficient method. Results All of the comprehensive quality indices including established rate of sanitary documents, verified rate of sanitary license, terminated rate of administrative punishment, coverage rate of inspection and monitoring, health examination rate and qualified rate of detected samples, from 1996 to 2000 evaluated by linear comprehensive coefficient and geometric comprehensive coefficient did not meet the criterion. Only one classified indices (1999～2000): established rate of sanitary documents, verified rate of sanitary license and terminated rate of administrative punishment reached the standard, others did not. Conclusion It was feasible to apply the comprehensive assessment method to evaluate the sanitary management of public places.

Objective To investigate the environmental factors affecting neonatal neurobehavioral development and its sensitivities.Methods Neonatal behavioral neurological assessment (NBNA)and lead levels in umbilical cord blood and meconium were determined for103randomly selected neonates delivered at the section of Obstetrics and Gynecology,First Metallurgical Construction Company Hospital,from January to October1999,and the other relevant factors were investigated by questionnaire at the same time.The NBNB total score was described as a dependent variable and24relevant factors such as umbilical cord blood lead and meconium lead level,etc,as independent variables.Logistic regression analysis was used to ana-lyze the associated factors at P=0.10level.Results The factors selected in the Logistic regression model included:gestational age,month of taking medicine in gestational period,hemoglobin concentration,pregnant womans psychology,meconium lead level and taking medicine during gestational period.Conclusion Neonatal neurobehavioral development could be affected by many factors.Good nutrition,longer gestational age and maintaining good psychological status during pregnancy might be benefi-cial to neonatal neurobehavioral development.However,taking medicine during the gestational period and a high meconium lead level could be harmful to neonatal neurobehavioral development.

ObjectiveTo evaluate two "up and down stair" methods used by hemiplegic patients.Methods40 cases with hemiplegia were randomly divided into two groups with 20 cases in each group. Patients in the group A went upstairs with health leg and downstairs with affected leg, while, patients in the group B upstairs with affected leg, downstairs with health leg, and then up and down stairs with health and affected leg alternated. Effects of two training menthods were compared.ResultsEach of two training methods had its advantage and disadvantage, but motor function and mobile ability of patients in the group B were better than patients in the group A (P<0.05).ConclusionHemiplegic patients Should choose different training method of up and down stairs according to his status, and not always choose the method of going upstairs with health leg and downstairs with affected leg.

Adult ; Animal Experimentation ; Female ; Hemorrhagic Fever with Renal Syndrome ; etiology ; Humans ; Male ; Medical Laboratory Personnel ; Middle Aged

Drug clinical trial is an important link in the chain of new drug research and development. The results of drug discovery and development directly depend on the extent of standardization of clinical trials. Therefore, improving the quality of drug clinical trials is of great importance, and drug clinical trial institutions play a crucial role in the quality management of drug clinical trials. After years of development, the overall level of drug clinical trials has advanced rapidly in China, and a large number of clinical trials of traditional Chinese medicine have also been carried out. However, there is still a big gap between our country and developed countries. Therefore, for the construction and management of Chinese drug clinical trial institutions, there is still a long way to go. This study aims to analyze the current development of drug clinical trial institutions in China and explore the existing problems from three aspects, including current situations of institutional organization and management, regional and professional distributions, and quality control. And some suggestions are put forward finally, including support of traditional Chinese medicine, introduction of drug-risk management system, and construction of information management.
China ; Clinical Trials as Topic ; standards ; Drug Evaluation ; Drug Therapy ; standards ; trends ; Drugs, Chinese Herbal ; standards ; therapeutic use ; Humans ; Quality Control ; Research

Objective To observe the clinical efficacy of Li Jiao Tong Fu (regulating the triple energizers and unblocking the Fu-organs) acupoint thread-embedding in treating functional constipation. Method Sixty eligible subjects were randomized into a treatment group and a control group, 30 cases in each group. The treatment group was intervened by acupoint thread-embedding at Tianshu (ST25), Shuidao (ST28), Zusanli (ST36), Shangjuxu (ST37), and Danchangshu (BL25), once every 2 weeks, totally for 2 sessions. The control group was by sham thread-embedding at the same points with the same treatment duration. The Patient Assessment of Constipation-Symptom (PAC-SYM), Patient Assessment of Constipation-Quality of Life (PAC-QOL), Self-rating Anxiety Scale (SAS), and two factors from PAC-SYM, hard bower movement and bloating, were observed before and after the intervention, and the clinical efficacies were compared. Result The total effective rate was 83.3% in the treatment group versus 46.7%in the control group, and the total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). The PAC-SYM, PAC-QOL, and bloating scores were significantly improved after the intervention in the two groups (P<0.05), and the improvements in the treatment group were more significant than that in the control group (P<0.05). The score of hard bower movement was markedly improved after the intervention in the treatment group (P<0.05), and the score in the treatment group was significantly lower than that in the control group (P<0.05). Conclusion Li Jiao Tong Fu acupoint thread-embedding is significantly effective in treating functional constipation, and it’s easy-to-operate, safe and reliable, and has a good compliance, thus worth promoting in clinic.

To investigate the relationship between gene p1 7 0 expression of human gastric carcino- ma tissues and histological types of the gastric carcinoma . 80 human gastric carcinoma tissues were taken from endoscopies and postoperations , and detected the p1 70 gene expression by peroxidase immuno- chemical stain method(Kit from US) . According to depth of yellow to brown stain on tumor cell mem- brane and/or cytoplasm ,if no colour stain indicated no p170 gene expression rif 70% stained 3+. The positive rate of p170 gene overexpression in gas- tric carcinoma tisaues by endoscopic . and postoperation were 66 % and 7 1% respectively. These histopathological types of gastric carcinomas with p 1 70 expression rate were 83% ( 5/6 ) in early carcino- mas ; 76% (26/34) in tubular adenocarcinomas ;64% (14/22) of undifferetiated adenocarcinomas ; 62% (5/ 8 ) in mucinous adenocarcinomas and 50% (2/4) in signet rign-form carcinomas. This study showed that p 1 70 gene overexpression gresented in human gastric carcinoma tissues and significantly in the group with metastatic lymph nodes. We considered that p 1 70 gene might be a new tumor marker for detection of gastric carcinoma.