Objective:To analyze the utilization of proton pump inhibitors ( PPIs) in a three-A hospital to promote the rational use. Methods:The sales records of PPIs used for outpatients and inpatients were retrieved from the hospital database from 2010 to 2015, and the consumption sum, DDDs and DDC were analyzed statistically. Results:The consumption sum and DDDs of PPIs in the hospital were increasing, and the compound annual growth rate ( CAGR) of consumption sum was 13. 84%. The proportion of con-sumption sum and DDDs for PPIs injections respectively was 82. 2% and 29. 6% in the six years. The proportion of consumption sum and DDDs of oral PPIs respectively was 17. 8% and 70. 3% in the six years. The top three drugs in the list of consumption sum were pantoprazole, lansoprazole and esomeprazole. Conclusion: The application amounts of pantoprazole sodium for injection and lanso-prazole sodium for injection are relatively large, and the overuse of PPIs for injection can not be excluded.

Objective To evaluate the role of the fractional dilatation and curettage (D&C) in the diagnosis of atypical hyperplasia of endometrium. Methods The retrospective analysis was performed in 48 patients diagnosed as atypical hyperplasia of endometrium and treated in our hospital from Aug.2009 to Dec.2010. We compared the pathology results of D&C with hysterectomy specimens, and investigated the reasons for the difference. Results The six patients (12.5%) with mild atypical hyperplasia of endometrium still presented with significant pathological changes after D&C (χ2 = 5.90, P＜0.05), 11 cases (22.9%) in 14 patients(29.2%) with moderate atypical hyperplasia (χ2=0.49, P＞0.01), 18 cases (100%) in patents with serious atypical hyperplasia, among which even 8 patients (44.4%) were verified as endometrial cancer. Conclusions There exists pathological discrepancy between the fractional D&C and hysterectomy specimens. Patients with severer atypical hyperplasia may have a higher risk of developing endometrial cancer.

Episodic tension-type headache is the most common headache in the general population and is usually self managed.Chronic tension-type headache may be highly disabling and often prompts medical consultation.Diagnosis is clinical,based on widely accepted and validated criteria and algorithm.Peripheral factors are implicated in episodic tension-type headache,whereas central factors probably underlie chronic tension-type headache.Simple analgesics,such as aspirin,are used for acute treatment.Amitriptyline and biofeedback assisted relaxation training have the best evidence of effectiveness for headache prevention.

Animals ; Dementia, Vascular ; blood ; psychology ; Erythrocyte Count ; Learning ; drug effects ; Male ; Memory ; drug effects ; Peptides ; pharmacology ; Rats ; Rats, Sprague-Dawley

Keratoconus is a progressive, non - inflammatory corneal thinning disorder that produces a unique spectrum of change in the surface curvature of the cornea. The suspected factors associated with the cause of keratoconus include genetic mechanisms, familial associations, allergy, atopy and so on, but environmental factors, such as abnormal rubbing, contact lens wearing and ultraviolet radiation may be easily ignored. Although it is commonly thought that keratoconus is a result of various pathological progress mediated by multiple factors, those chronic trauma could play important roles in the pathological progress. The classic definition of keratoconus is still referred as a non - inflammation disorder with malnutrition of keratectasia, more and more clinical evidences and experimental results that may refute this concept. It may be due to the long-term persistent chronic trauma resulted from eye rubbing, contact lens or ultraviolet radiation. Under this conditions, the increased release of inflammatory mediators and matrix metalloproteinases may accelerate keratocyte apoposis and enzyme metabolism disorders, with the result of matrix cell lost, tensile strength decreased and keratectasia. Here, for some papers known about the relationship between chronic cornea trauma and keratoconus were reviewed and discussed its possible causal relationship.

Objective: To investigate the histopathologic features of rim enhancement MRI of breast infiltrating ductal carcinoma (IDC). Methods: Routine and dynamic contrast enhanced MRI was used to examine 65 patients with breast lumps. Thirty of the 65 patients who were pathologically confirmed to have breast IDC were included in the present study. The manifestations of dynamic contrast enhanced MRI and the histopathologic parameters of the masses (the size of cancer nest, stroma type, microvessel density and degree of fibrosis) were observed. And the relationship of MR findings with the above-mentioned histopathologic features was analyzed. Results: Peripheral rim enhancement was obvious in IDC and a type-III (washout) time/signal intensity course was the dominant type (17/30,56.7%). The average enhancement rate during the first post-contrast minute(ΔSI1 %) was higher than 75% in IDC. The 30 IDCs fell into small (13,43%), medium(12,40%), and large (5,17%) groups according to the size of cancer nest; and into delicate(5,17%), narrow(16,53%), and broad(9,30%) groups according to the cancer stroma type. Early rim enhancement was associated with a small cancer nest (P<0.05), a high ratio of peripheral-to-central microvessel density, and a low ratio of peripheral-to-central fibrosis (P<0.01). Delayed rim enhancement was significantly associated with narrow stroma (P<0.05). Conclusion: Rim enhancement and washout sign on contrast-enhanced MR imaging of the breast IDC are associated not only with angiogenesis, but also with various histological features of the cancinoma, including the size of cancer nests, width of stroma, and degree of fibrosis.

Animals ; Ear Canal ; surgery ; Female ; Gene Expression ; Hypothalamus ; metabolism ; Nerve Block ; Pregnancy ; RNA, Messenger ; genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate ; genetics ; metabolism

Animals ; Female ; Gene Expression Regulation, Developmental ; Inferior Colliculi ; metabolism ; N-Methylaspartate ; genetics ; metabolism ; RNA, Messenger ; genetics ; Rats ; Rats, Sprague-Dawley ; Receptors, N-Methyl-D-Aspartate ; genetics ; metabolism

Brain Computer Interface(BCI) is a direct information communication and control channel established between human and computer or other electronics devices and it is a wholly new communication system that does not depend on the brain's normal output pathways of peripheral nerves and muscles.The general constitutions and principles of BCI systems are introduced.In addition,research methods based on electroencephalograph are discussed and the existing problems and future trends of BCI are pointed out.

Objecive:To observe the incidence of early enteral nutrition-related complications in severe brain-injured patients in ICU and its associated factors.Methods:78 nutrition severe brain-injured patients(GCS 4-8) in ICU receiving enteral nutrition were all carried out for GCS scoring.The enteral feeding amount and speed,serum albumin(ALB) and intestinal feeding tolerance were observed.The incidence rate of all kinds of complications related to enteral nutrition was summarized.Results:The patients with lower GCS had lower total feeding amount,prolonged feeding duration and higher incidence rate of complications.The diarrhea was negatively related with serum ALB level and GCS. Conclusion :Enteral nutrition-related complications are related with the severity of disease and Alb level.Some critically ill patients can not sustain total enteral nutririon(TEN),and parenteral nutrition is necessary.