The changes of arginine vasopressin (AVP) levels in plasma in some physiological states in healthy men were studied by RIA. Mean plasma AVP concentration in 30 normal adults after 12 h of overnight water deprivation was 10.6?2.5 pg/ml, and decreased from 11.85?6.0 to 1.8?1.6 pg/ml 1 h after an oral water load (20 ml/kg) administered in 16 dehydrated normal subjects (P

Peking Union Medical College is the earliest college to launch the clinical medicine specialty of 8-year program.The achievements that our college obtains are obvious to all.The education item of admission for 7-year switching to 8-year in the clinical medicine specialty was started to put in practice in 1995 and has been carried out for 12 years.The item has accelerated the flourish of science,facilitated the diversification of students' source and knowledge configuration and brought out a large quantity of high level medical persons with high quality The successful fulfillment of the education item of admission for 7-year switching to 8-year in the clinical medicine specialty has enriched our experiences of running college and explored a new mode of training high level medical persons for adopting to the situation of our country.

Objective To hy out a course of nursing intervention programmes for patients undergoing coronary intenrentional therapy on the basis of the health belief model(HBM),and estimate its clinical effectbv measuring the change ofquality of life(QOL).Methods 64 patients were randomly selected and divided into 2 groups,the experimental group was treated with the nursing intervetnion on the basis of the HBM,and the control group was treated with routine nursing measures.The quality of life wes compared between the two groups after intervention.Results The total score of QOL,the restricted ability of activity,the therapy satis-faction and the subiective feelings of patients to disease of the two groups had significant difference after inter- vention,P<0.01,but no difference in angina stabilization and occurrence was seen,P>0.05. Conclusions Nursing programmes on the basis of the HBM make the QOL of patients to improve evidently.

As antigen-presenting cells, DCs are the most potent and unique,they can stimulate the primitive T cells. They play a major role in initiating the immune response. Tumor infiltrating dendritic cells (TIDCs) can reflect the antitumor immune capability of the host. The density of TIDC perhaps is associated with the prognosis in some cancers. The disablement of TIDCS is partly due to the phenotype they have. Perhaps it is the immunosuppressive factors secreted by tumor cells that have changed their phenotype.The studies about TIDCs provide the basis for DC-mediated antitumor immune therapy,and suggest the use of DC to treat tumors through different approaches.

Arrhythmogenic right ventricular cardiomyopathy(ARVC) is a cardiac muscle disease characterized by peculiar right ventricular involvement that precipitates ventricular arrhythmias and sudden death.ARVC is a major cause of sudden death in the young and athletes.It is familial origin in 50% to 70% of cases,which follows an autosomal in heritance pattern.The pathology consists of a genetically determined dystrophy of the right ventricular myocardium with fibrofatty replacement.Clinical diagnosis can be achieved by demonstrating functional and structural alterations of the right ventricle,depolarization and repolarization abnormalities,arrhythmias with the left bundle branch block and fibro-fatty replacement through endomyocardial biopsy.Clinical research has indicated that successful treatment of ARVC is based on lifestyle modifications,prophylactic therapy(antiarrhythmic drugs,catheter ablation and implantable cardioverter defibrillator)to prevent sudden death.

Objective To compare clinical value of peripheral blood collection and venous blood collection methods in blood tests.Methods 467 patients who received blood test were selected.The venous blood and peripher-al blood were collected,the indicators of blood test were detected,and the test results were analyzed.Results The white blood cell count (WBC),red blood cell count (RBC),platelet count (PLT),red blood cell hematocrit (HCT),hemoglobin (HB)of venous blood were (5.7 ±1.2)×109 /L,(3.72 ±0.48)×109 /L,(218.0 ±57.5)× 109 /L,(41.8 ±19.8)g/L,(115.7 ±13.8)g/L respectively,those of peripheral blood were (6.7 ±3.4)×109 /L, (3.62 ±0.72)×109 /L,(204.0 ±87.7)×109 /L,(32.7 ±20.7)g/L,(103.6 ±19.6),the differences were statis-tically significant (t =5.994,2.497,2.885,6.865,10.908,all P <0.05).The mean red cell hemoglobin concentra-tion (MCHC),mean red cell volume (MCV),mean erythrocyte hemoglobin (MCH)and other indexes had no signifi-cant differences(all P >0.05).Conclusion The test results in patients with venous and peripheral blood was quite different,venous blood test results obtained with greater value in clinical use,it is recommended that routine blood test used venous blood.

Objective To explore cephalosporinase from nosocomial Klebsiella pneumoniae infection and their drug-resistant characteristics among the ICU patients so as to provide an instruction for rational clinical medication.Methods 67 samples were identified with VITEK-60 automated system.The strains producing AmpC β-lactamases were screened with cefoxitin disk diffusion method recommended by the CLSI,and confirmed by cefoxitin three-dimensional test.AmpC β-lactamase genotype was differentiated by PCR-sequencing and susceptibility tests which were done with the Kirby-Bauer method recommended by the CLSI.Results In the 67 isolates of Klebsiella pneumoniae,11 strains(16.4％) were found to produce AmpC β-lactamases.The drug-resistant genotype for all the 11 AmpC-positive strains was DHA-1.AmpC-producing strains developed multi-drug resistance,especially for broadspectrum β-lactam antibiotics and enzyme inhibitors.β-lactamases-producing strains were more resistant than non-producing ones.Conclusion Klebsiella pneumoniae in ICU patients has a higher proportion of producing AmpC β-lactamase strains,which are all of DHA-1 genotype and have multi-drug resistance.

Objective:To explore the effects of nutritional intervention on the nutritional status,cognitive function and activities of daily living (ADL) in patients with Alzheimer's Disease (AD).Methods:90 AD patients were randomly divided into the control group and the intervention group,with 45 cases in each group.Patients in the control group received anti-dementia drugs,and patients in the intervention group additionally received TPF-T as the oral nutritional supplement.The nutritional status and nutritional biochemical indicators,cognitive function and ADL of two groups were evaluated when enrolled and 6 months later after the treatment.Results:After 6 months'treatment,the nutritional status,MMSE,ADL scores and nutritional indicators of patients in the intervention group were significantly improved compared to the control group (P ＜ 0.05).Conclusion:Nutritional intervention can effectively improve the nutritional status,cognitive function and ADL of patients with dementia.

Objective:To study the curative efficacy of functional training focusing on muscle group around shoulder for subacromial impingement syndrome.Method:Forty five patients with subacromial impingement syndrome (SIS) were randomly grouped into three groups (fifteen patients for each group).Patients in Group Ⅰ were trained only on muscles around scapula.Patients in Group Ⅱ were treated on rotator cuff muscles.While patients in Group Ⅲ were treated on both.The training goes every 2 days and last for 4 weeks.The indexes for evaluating curative efficacy included:the Neer-test,the Hawkins-test and the Peen Shoulder Score.These indexes were measured immediately and three months after the four week treatment.Result:After treatment of the functional training focusing on muscle group around shoulder,Neer-tests and Hawkins-tests of all of patients were changed from positive to negative,the degree of pain compared with pain before the treatment declined apparently(P＜0.01),at the same time,the degree of satisfaction and the function went up remarkablely(P＜0.01).Compared with group Ⅰ and group Ⅱ,it dropped the most notably on the degree of pain in the group Ⅲ(P＜0.01),however,the degree of satisfaction and the function rose most apparently (P＜0.01) Conclusion:The curative efficacy of functional training focusing on muscle group around shoulder for sub-acromial impingement syndrome was effective apparently.But the efficacy of treated focusing on both muscles around scapula and rotator cuff was the most remarkably.

Objective To study the clinical implementation strategy analysis about fast track surgery ( FTS) used in right co-lon cancer radical.Methods 72 patients with right colon cancer laparoscopic treatment in our hospital from June , 2013 to Decem-ber, 2014 were randomly selected and divided into observation group ( n=36 ) and control group ( n =36 ) by numeric randomized method.Observation group adopted treatments based on FTS while control group treated with conventional laparoscopic radical prosta-tectomy.Stress reaction, operation time, intraoperative blood loss, exhaust time, defecation time, stop the infusion time, drainage a-mount and postoperative drainage tube root out time, postoperative hospital stay and postoperative complications of two groups were sta-tistically analyzed.Results Preoperative blood cortisol, fasting blood glucose, serum IL-6 and plasma CRP level of two groups, op-eration time and compare differences of 2 groups had no statistical significance (p>0.05).Postoperative 24 h blood cortisol, fasting blood glucose, serum IL-6 and plasma CRP level of two groups were higher than that of preoperative.Postoperative 24 h blood corti-sol, fasting blood glucose, serum IL-6 and plasma CRP level of observation group were lower than that of the control group, and the difference was statistically significant (p<0.05).In observation group, the exhaust time, defecation time, drainage tube root out time, stop infusion time and postoperative hospital stay of observation group were (43.62 ±8.21) h, (50.42 ±6.85) h, (5.51 ± 1.08), (4.12 ±0.85)d and (5.42 ±1.13)d respectively, which were shorter than the (56.65 ±8.26)h , (64.78 ±8.26) h, (9.53 ±4.13)d, (7.78 ±1.43) d and (10.62 ±2.14)d of the control group, and the difference was statistically significant (p <0.05).Rainage amount of observation group[(602.54 ±165.78) ml] was less than that of the control group[(1265.28 ±572.94) ml];And the total complications incidence of observation group (8.33%) was lower than that of the control group (25.00%), and the difference was statistically significant (p<0.05).Conclusion Implementation of laparoscopic treatment based on FTS used in right colon cancer radical can effectively promote patients recovery and reduce complications.thus it is worthy of clinical promotion use.