Clinical Trials as Topic ; standards ; Humans ; Quality Control

Aluminum ; urine ; Humans ; Metallurgy ; Occupational Exposure ; analysis ; Reproducibility of Results ; Spectrophotometry ; methods

Ascorbic Acid ; adverse effects ; immunology ; Child, Preschool ; Drug Hypersensitivity ; etiology ; Family ; Female ; Humans ; Male

Colorectal Neoplasms ; therapy ; Humans ; Neoadjuvant Therapy

Humans ; Neoplasm Recurrence, Local ; prevention & control ; Rectal Neoplasms ; pathology

To augment the levels of diagnosis and treatment for colorectal cancer and make them standardization in China, the Ministry of Health of the People's Republic of China released Chinese Standard for The Management of Colorectal Cancer (2010) in November 4, 2010. This standard incorporates the most recent progresses in colorectal cancer, and it provides standard guidelines with respect to diagnosis, pathologic examination, surgery, adjuvant therapy in the management of colorectal cancer in China.
China ; Colorectal Neoplasms ; diagnosis ; therapy ; Humans ; Practice Guidelines as Topic

BACKGROUND:Lung cancer stem cel s are tightly related to the treatment and prognosis of lung cancer. We can provide more references for clinical diagnosis and treatment of lung cancer through the study on the tumorigenicity and surface markers of lung cancer stem cel s. OBJECTIVE:To explore the enrichment methods for lung cancer stem cel s and cel ular tumorigenicity. METHODS:Lung cancer stem cel s were induced in serum-free culture medium containing epidermal growth factor, insulin-like growth factor 1, and basic fibroblast growth factor. Then, the expressions of related surface markers were detected using immunofluorescence method. After that, mice were implanted subcutaneous with lung cancer stem cel spheres to understand the tumorigenicity of lung cancer stem cel s. RESULTS AND CONCLUSION:Lung cancer stem cel s under serum-free induction and culture were changed to sphere-forming cel s, and the immunofluorescence detection showed that over 80%of sphere-forming cel s were positive for CCSP, SP-C and OCT4. After transplantation of sphere-forming cel s, the mice showed a high tumorigenicity. These findings indicate that sphere-forming cel s are formed after serum-free suspension culture of lung cancer stem cel s, which have a higher tumorigenicity.

Crohn Disease ; epidemiology ; surgery ; Humans

For stage Ⅱ colon cancer patients after surgery,the benefit of adjuvant chemotherapy remains controversial.Several studies indicate that the patients with high-risk stage Ⅱ colon cancer can benefit from adjuvant chemotherapy after surgery.According to the clinical and pathological features,the stage Ⅱcolon cancer patients including T4 lesion,perforation,peritumoral lymphovascular invasion can benefit from the adjuvant chemotherapy of oxaliplatin.In the horizontal of molecular and genetic levels,the stage Ⅱ colon cancer patients can express high microsatellite instability (MSI-H) and cannot benefit from the chemotherapy of Fluorouracil.The guiding functions of 18q loss of heterozygosity (18q LOH),Cx43 and gene expression profiling in adjuvant chemotherapy are still unclear,and need further study.

Xuening Granule is a traditional Chinese patent medicine based on San Huang Xie Xin Tang. The effective Component of each herbal medicine were extracted individually and then mixed together to form granules. This process avoids the chemical reactions among the drugs in order to enhance the the effects. The major contents are determined and differentiated to control its quality