Objective To investigate the curative effect of telbivudine versus lamivudine in chronic hepatic B with a therapy of 48 weeks. Methods 94 patients who were diagnosed chronic hepatitis B were investigated. The therapeutic group and the control group (n = 47) were respectively assigned to receive 600mg of telbivudine and 100mg of lamivudine in 48 weeks. Copies of HBV-DNA、serum markers、alanine transarninase(ALT) level were tested before therapy and 4 weeks、12 weeks、24 weeks、48 weeks in the the course of treatment. The HBV-DNA conversion、HBeAg conversion and the normal rate of the ALT were compared. Results The copies of HBV-DNA decreased as the treatment progressing,especially at the 4 thweek. Conversion rate of the HBV-DNA of the telbivudine group was 72.3% ,which was higher than the lamivudine group 42.6%. There is a significant difference between two groups (x2 = 8.530,P ＜ 0.05). 95.7% of ALT in the telbivudine group revived to normal level versus 91.5% of the lamivudine group became normal. There is no significant difference between two groups (P ＞ 0.05). At the end of treatment,the rate of the HBeAg converting to negative in the telbivudine group is 38.3% versus the lamivudine group 31.9%, but there is no significant statistical difference between two groups(x2 = 0.420 ,P ＞ 0.05). The frequence of seroconversion of HBeAg in the telbivudine group is 23.4% versus the lamivudine group 17.0%, but no statisticall difference between two groups (x2 = 0. 594, P ＞ 0.05). Conclusion It was more effective to treat the HBeAg positive chronic hepatitis with telbivudine than lamivudine,and lower frequence of seroconversion of the HBV-DNA、HBeAg.

Service for childbirth is obviously special.Because every tache in childbirth can affect the health and life safe of babies and mothers.At present the humanistic service is still not popularized in maternity of hospitals.So it is possible to happen contradictions or bothers between doctors and patients.Therefore,thinking from ethics,we should adopt effective measures,develop the humanistic service and management,and satisfy the lying-in women completely,to establish harmonious relationships between doctors and pationts

Glaucoma,the major cause of global irreversible blindness,is a chronic neurodegenerative disease of the optic nerve.Apoptosis of retinal ganglion cells (RGCs) and progressive loss of optic nerve axons results in structural and functional deficits in glaucoma patients.Growing evidence obtained from clinical and experimental studies over the last decade strongly suggests the involvement of the immune system in the neurodegenerative process of glaucoma.This review aims to provide a perspective on the complex interplay of cellular events during glaucomatous neurodegeneration that involves aberrances or dysfunctions of immune system,such as ocular immune privilege,glial activation response,T cell-mediated immune responses,autoantibody-mediated immune responses,complement fixation reaction and aging,oxidative stress.The complex interplay of cellular events amplify the primary injury process and contribute to disease progression by oxidative stress and immune response,ultimately lead to cell death with loss of RGCs.

Recently,the interest in a new surgical procedure named natural orifice transluminal endoscopic surgery has blossomed worldwidely.During these several years,quite a number of natural orifice transluminal endoscopic surgery experiments have been carried out on porcine models and even on humans,including transvaginal cholecystectomies,transgastric appendectomies,transvaginal appendectomies,transvesical peritoneoscopies,etc.This review article aims to discuss the current research status and the challenges of orifice transluminal endoscopic surgery.

Nosocomial infection had been the focus conc erned by society at home and abroad since the viral infection such as HIV、HBV and HCV which had seriously threaten the human health worldwide. We should strengthen t he blood products and syringe management and implement sterilization measure，wi th that safe blood starts with me. Because of that quite a few of new human viru ses continually emerged in recent years， control and prevention of nosoc omial viral infection was currently imperative, important and formidable project s and global thorny issue of public health in the 21st century too.

OBJECTIVE: To analyze the status quo and developing trend of the use of antihyperlipidemics drugs in Chongqing so as to provide information for the research,production,marketing and clinical application of these drugs.METHODS: The consumption sum,DDDs and the defined daily cost(DDC) of Antihyperlipidemics in 18 hospitals in Chongqing city from 2004 to 2006 were analyzed statistically.RESULTS: Both the DDDs and the consumption sum of the antihyperlipidemics showed uptrend over the 3 years,with statins dominating the first place over the 3 consecutive years,making up 48.37%,47.74%,and 61.79% respectively,followed by Chinese patent medicines and fibrates.Xuezhikang and simvastatin ranked among the first two places in terms of DDDs.CONCLUSION: Statins and Chinese patent medicines occupied a predominant role among all the antihyperlipidemic drugs in Chongqing,and their use had a bright prospect.

OBJECTIVE To study the treatment effect of traditional Chinese medicine on juvenile seasonal allergic rhinitis.METHODS The patients with allergic rhinitis presented to the clinic three or more times included in this study.All of the patients were treated with traditional Chinese medicine and divided into young group and adult group.Symptom score were recorded in each time presented to the clinic.RESULTS There were 15 patients cured, 30 patients improved and 0 patients unimproved in the young group.While, in adult group, there were 10 patients cured, 21 patients improved and 10 patients unimproved.There was a significant difference between the two groups(?2=29.0323, P

Objective:To explore the molecular mechanism of Gold Theragran in the protection of renal function,and the inhibition of renal local rennin angiotensin(RA)system in the early diabetic nephropathy(DN),and to provide the theoretical and experimental data for clinical application to prevent the DN.Methods:The experimental rats consisted of 64 healthy SD rats,average 180-220g,female and male both a half,rat model of DN was established by improved method of YANG Junwei,s method of intraperitoneal injection of STZ after nephrectomy.8 Rats was taken as normal group,the rest of them were randomly divided into 5 groups:high,middle and low dose groups of Gold Theragran,Valsartan group,model group.In each group,blood glucose,blood lipids,urine microalbumin per 24 hours,KW/BW,renal angiotensin converting enzyme,plasma and renal angiotensin Ⅱ,and its type 1 receptor were observsd and measured.Results:①Rat's general status in each treatment group was improved compared with the DN model group.②The levels of serum glucose decreased in all treatment groups,especially the high-dose group and mid-dose group were significant(P0.05).③The levels of abnormally high lever of TG,TC decreased in treatment groups,especially the high-dose group and mid-dose group were significant(P0.05).The high-dose group had further function to regulate the lipids in the 28th day than in the 7th day(P0.05).Conclusion:Firstly,Gold Theragran had a therapeutic effect of protecting the renal function on the experimental DN rats;Secondly,Gold Theragran can inhibit the abnormal state of activated rennin angiotensin system in diabetic nephropathy,delay the development of diabetic nephropathy;Thirdly,with the treatment course prolonged,the effective of Gold Theragran might be more obvious,and different dose groups show dose-effect-dependent relationship.

The structure and trends of individual organic biomass and alkaloid content of two wilCoptis species, C. omeiensis and C. gulinensis, on Mt. Emei, were studied by testing and analy-psing samples collected from several points. The results were compared with two cultivated C.species, C. chinensis and C. deltoidea. The accumulative characters and laws of biomass andeffective composition of the two wild species were revealed.

Objective examine the current status of Science and Technology Novelty about Medicine and Health Sciences in the Guangzhou Military Region during 2010 to 2013.Methods Using Microsoft Excel software to conduct statistical analysis on data that including the novelty of the client' s new projects,subject classification,the level of project award application,client unit,type of requested projects,innovative items,etc.Results The total number of applying for project innovation checking showed a decreasing trend in the Guangzhou Military Region;the majority of awarded application was for the third Prize;and the requirested for new project innovation checking is far less than project innovation award checking.Conclusions The center should actively promote the understanding for the innovation of the new projects among the research groups,and improve the class of prize award.