ObjectiveTo discuss the relationship between serum homocysteine (Hcy) level and severity of acute coronary syndrome(ACS) through measuring the level of serum Hey in the patients with ACS.Methods95 patients who were diagnosed ACS were divided into two groups:40 cases of unstable angina(UA) and 55 cases of a cute myocardial infarction(AMI).30 individuals were chosen as normal control(NC).In addition,according to the results of coronary angiography,the same 95 patients were further divided into three subgroups which were single-vessel disease( 28cases),double-vessel disease ( 36cases ) and multi-vessel disease ( 31 cases ).Level of serum Hcy was measured in all groups.ResultsSerum Hcy level of ACS patients was significantly higher than NC group( P ＜ 0.01 ).The level of serum Hcy in AMI group was significantly higher than that in UA group( P ＜ 0.05 ).The Hcy level in the multi-vessel disease group,double-vessel disease group and single-vessel disease group were increased in turn,and the difference of pairwise comparison was statistically significant ( P ＜ 0.05 ).ConclusionThe serum Hcy level has rela tionship with the severity of coronary lesions and is directly proportional to the number of coronary artery lesions.The result suggests that the level of serum Hcy maybe play an important role in the prevention,diagnosis,treatment and monitoring of ACS.

Diagnosis, Differential ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Neoplasms ; diagnosis ; drug therapy ; Phytotherapy ; Quality of Life ; Treatment Outcome

Child, Preschool ; Facial Paralysis ; etiology ; Female ; Hand, Foot and Mouth Disease ; complications ; drug therapy ; Humans

Objective To investigate the effect of intensive nursing intervention on the secondary infection in chemotherapy of elderly patients with lung cancer.Methods 168 cases of elderly lung cancer patients whose neutrophil ≤ 1.0×109/L during chemotherapy were randomly divided into two groups,namely,the intensive care group and the control group,with 84 cases in each group.The control group was given routine nursing of infection prevention,while the intensive care group was given intensified nursing for infection prevention.A contrastive analysis was conducted in terms of the incidence,clinical characteristics and the duration of antibiotic treatment of the two groups of patients with secondary infection.Results The secondary infection rate of the intensive care group was lower than that of the control group during chemotherapy.What's more,the duration of fever and treatment of the intensive care group was shorter than that of the control group,hence the patients were safe during infection period.The difference was statistically significant.Conclusions Strengthening the nursing intervention can reduce the incidence rate of secondary infection in aged patients with lung cancer,increase the tolerance of patients to chemotherapy and ensure the successful completion of the chemotherapy cycle,prolong the life span of the patients with an improved quality of life.

Anal Canal ; surgery ; Humans ; Postoperative Complications ; Rectal Neoplasms ; surgery

Objective To understand the utilization of antibiotics for acute upper respiratory infection through retrospectively analyzing the prescription in the outpatient department in a whole year,therefore to improve the rational drug using in primary healthy institutions.Methods Prescriptions from the outpatient department,Jan.2010 to Dec.2010 were managed in Excel software and the utilization was analyzed.Results In a total of 6101 prescriptions,2462(40.35％ ) were for upper respiratory infection.Of the 2462 prescriptions,1962(79.69％ )used antibiotics.The amount of prescriptions and the rate of antibiotics used were significantly higher than those for other infection diseases.Conclusion The investigation shows antibiotics abuse in primary healthy institution has become a severe problem.While the stuff in primary healthy institution are trained for some specific aims,the promotion should be spread to let doctors and patients know the danger of antibiotics abuse.

Objective Investigate the clinical significance of bone marrow minimal residual disease (MRD) detection to prognosis and therapeutic evaluation in acute leukemia (AL) after complete remission (CR). Methods Forty-three cases of bone marrow specimens in patients with acute leukemia were collected from 209-2012. The MRD was detected using multiparameter flow cytometry (FCM). The detection was performed from the beginning of induction chemotherapy by CR,and detected at 1,3,6 and 12 months. According to the CR detection for the first time, the induced MRD levels were obtained after treatment, then 43 patients with AL were divided into negative (MRD<10-4) and positive (MRD>10-4) two groups. Results The recurrence rate after three years of the two groups was 0 and 80%, respectively. There was a significant difference in the recurrence rate ( <0.05) . The recurrence rate of positive group was significant higher than that of negative group ( <0.05) when the morphologic of MRD was complete remission. Conclusion Using FCM to detect AL MRD, MRD>10-4 AL-CR have the high recurrence rate, and the recurrence of positive group have appeared early than traditional MRD bone marrow morphology. The continuous MRD detection of AL-CR has important clinical significance in the prognosis and early prediction for recurrence.

Objective To explore the application effect of 4R crisis management in patients with mechanical ventilation in intensive care unit(ICU).Methods 88 patients with mechanical ventilation in ICU were selected as the study subjects,by random number table method they were divided into observation group and control group, 44 cases in each group.The control group was treated with basic nursing intervention,the observation group received 4R crisis management of nursing intervention.After the implementation of different nursing intervention,the incidence of pressure ulcers,prevention effect and nursing satisfaction,crisis event occurrence and the quality of care were com-pared between the two groups.Results The incidence rate of pressure ulcers of the observation group was 2.27%, effectively preventive rate was 95.45%,the crisis event occurrence rate was 4.55% and nursing satisfaction rate was 97.73%,nursing quality score was (93.78 ±3.19)points,which were significantly better than those of the control groups[20.45%,68.18%,47.73%,75.00%,(87.91 ±2.75)points](χ2 =5.53,9.24,19.07,7.82,t =9.25,all P <0.05).Conclusion 4R crisis management nursing intervention can effectively improve the ICU mechanical ven-tilation patients crisis events,improve the quality of nursing and nursing satisfaction.

Objective To observe the clinical efficacy of aconite-cake-partitioned moxibustion plus medication in treating coronary heart disease (CHD) with stable angina pectoris.Method Ninety patients with CHD stable angina pectoris were randomized into a treatment group of 46 cases and a control group of 44 cases. The control group was intervened by the secondary preventive treatment for CHD, while the treatment group was intervened by aconite-cake-partitioned moxibustion at Neiguan (PC 6), Guanyuan (CV 4) and Danzhong (CV 17) in addition to the treatment given to the control group. The two groups were treated once a day, for a total of 10 sessions. The reduction-termination rate of Nitroglycerin and clinical efficacies were compared between the two groups.Result The total effective rate was 89.1% in the treatment group versus 72.7% in the control group, and the between-group difference was statistically significant (P<0.05). The reduction-termination rate of Nitroglycerin was 84.8% in the treatment group versus 63.6% in the control group, and the between-group difference was statistically significant (P<0.05).Conclusion Aconite-cake-partitioned moxibustion is an effective method in treating CHD with stable angina pectoris.

OBJECTIVE:To establish a method for simultaneous determination for ginsenoside Rb1,ginsenosides Rc,ginsen-osides Rb2 and ginsenosides Rd in Shengmai powder. METHODS:HPLC was performed on the column of Agilent ZORBAX Ex-tend-C18 with mobile phase of acetonitrile-0.1% formic acid(gradient elution) at a flow rate of 1.0 ml/min,wavelength was 203 nm,column temperature was 30 ℃ and the volume injection was 10 ml. RESULTS:The linear was 0.78-38.75 μg for ginsenoside Rb1(r=0.9996),0.51-25.50 μg for ginsenosides Rc(r=0.9996),0.43-21.50 μg for ginsenosides Rb2(r=0.9997)and 0.20-10.00 μg for ginsenosides Rd(r=0.9997);RSDs of precision,stability and reproducibility tests were lower than 2%;recoveries were 96.6%-101.2%(RSD=1.6%,n=6),97.0%-102.1%(RSD=1.7%,n=6),99.1%-102.8%(RSD=1.3%,n=6)and 96.3%-101.1%(RSD=1.6%,n=6). CONCLUSIONS:The method is simple,rapid with good stability,reproducibility and high precision,and can be used for quality control of Shengmai powder.