OBJECTIVETo explore the efficacy and safety of prostatic arterial embolization (PAE) in the treatment of benign prostatic hyperplasia ( BPH) in high-risk aged males.

METHODSWe retrospectively analyzed the clinical data about 21 high-risk BPH patients aged 77-91 (mean 80) years treated by PAE.

RESULTSPAE was successfully performed in all the 21 patients, with the operation time of 90-120 min. At 2 weeks, 3 months, 6 months, and 12 months after surgery, the International Prostate Symptom Scores (IPSS) were 18.3 ± 3.1, 9.8 ± 2.7, 9.4 ± 2.5, and 10.1 ± 2.2, the quality of life scores ( QOL) were 4.6 ± 1.4, 4.3 ± 1.2, 4.6 ± 1.1, and 4.9 ± 0.6, the maximum urinary flow rates ( Qmax) were (12.5 ± 2.5), (15.8 ± 2.4), (16.6 ± 2.2), and (16.3 ± 1.8) ml/s, and the postvoid residual urine volumes (PVR) were (35.0 ± 3.4), (13.0 ± 3.3), (10.0 ± 3.0), and (8.0 ± 2.5) ml, respectively, markedly improved as compared with the baseline (IPSS: 24.5 ± 3.7, QOL: 5.7 ± 1.6, Qmax: [8.3 ± 2.1] ml/s, and PVR: [98.0 ± 11.0] ml), with statistically significant differences in IPSS, QOL, Qmax, and PVR (all P < 0.05). The maximal velocity of blood flow in the prostate was obviously decreased and the prostate volumes were (74.4 ± 4.8), (42.5 ± 4.4), (38.3 ± 4.0), and (36.7 ± 3.5) cm3 at 2 weeks, 3 months, 6 months, and 12 months, respectively, also significantly reduced in comparison with (84.3 ± 5.4) cm3 preoperatively (all P < 0.05).

CONCLUSIONPAE is a safe and effective option for the treatment of BPH in high-risk aged males.

Aged ; Aged, 80 and over ; Arteries ; Blood Flow Velocity ; Embolization, Therapeutic ; methods ; Humans ; Male ; Prostate ; blood supply ; Prostatic Hyperplasia ; therapy ; Quality of Life ; Retrospective Studies ; Treatment Outcome ; Urination

Objective The aim of the study is to approach the clinical significance of the change of ST segments after di- rect percutaneous transcoronary angioplasty(PTCA) combined with Lipo-PGE_1 in treating Acute Myocardial Infarction (AMI).Methods The change of the ST segments on EKG of 76 patients with AMI are observed in 30 minutes after un- derwent direct PICA combined with Lipo-PGE_1,and the relations are analyzed that are prospectively to their therapy effect,the degree of injured cardiac muscle,the cardial functions,and the prognosis.Results The patients who treated with the PCTA combined with Lipo-PGE_1 ST segments on EKG 30 minutes after operations reduced significantly,cardiac muscle is injured lowly,their cardial functions are better.Conclusion The change of ST segments after direct percutane- ous transcoronary angioplasty (PTCA) combined with Lipo-PGE_1 in treating acute myocardial infarction is one of the guide line to estimate the perfnsion of cardiac muscle,and to estimate prognosis farther.

Objective To investigate the correlation between renal biopsy pathology(RBP) and Renal intertitial fibrosis (RIF).Methods 112 cases of RIF patients were collected in our hospital who had done RBP examination and were di- vided into four groups based on RIF degree.Results 45 cases in light group,22 cases in moderate group,15 cases in se- vere group and 30 cases in control group.With different RIF degree,renal pathology were different.Conclusion IgAN、 LN、FSGS were much more in moderate and severe RIF group compared with those of other groups,MSPGN were seen in any RIF degree groups.

Objective:To investigate the eating disorder and mood among students of a female university in Beijing.Methods:352 female students from a same-sex college in Beijing,between the age of 17-25 years were in- vestigated by Eating Disorder Inventory(EDI)and Profile of Mood States-Short Form(POMS-SF).Their weight and height were also collected for calculating for their body mass index(BMI).Results:Female university students showed serious tendency of eating disorder.The negative attitudes to body and body satisfaction were serious among normal BMI female university students.The behaviors and attitudes to eating disorders among the students of fresh-woman and senior were significantly higher than other grades(x~2=17.94,P

Objective To study the relationship between the liver sinusoidal pathological changes and portal hypertension during the dimethylnitrosamine (DMN) induced liver fibrosis in rats. Methods The rat liver fibrosis model was established by peritoneal injection of DMN (at a dose of 10 mg/kg, 3 times a week, for 4 weeks) in 40 male Wister mice. In the control group of 24 healthy mice, saline solution was injected peritoneally. The dynamic changes of liver fibrosis were observed at different time points (1, 2, 3 day, 1, 2, 4, 6 and 8 week). The pressure of portal vein (Ppv) was directly measured by the intubation of mesentery anterior vein in 5 mice of the model and 3 of the control. The expressions of type Ⅳ collagen (Col Ⅳ), laminin (LM) and type Ⅰ collagen (Col Ⅰ) were detected by immunohistochemistry. Hepatic ultrastructure was observed by electron microscopy. Results Positive expression of Col Ⅳ was observed in the normal liver sinusoidal walls. The various intensities of positive staining of Col Ⅳ were observed in the liver sinusoidal walls of the fibrosis model. Positive expressions of LM and Col Ⅰ increased, and the strongest positive staining displayed in the 4 week model rats. Meanwhile, the fenestrae in the sinusoidal endothelial cells (SECs) were lost and the basal membrane was formed. There was a remarkable positive correlation between the Ppv and the expressions of LM in the DMN induced rat fibrosis( P

Objective To evaluate the efficacy and safety of two kinds of hydrotalcite, Weidimei and Talcid, in treating bile reflux gastritis. Methods Thirty patients with bile reflux gastritis confirmed by endoscopy were equally divided into experimental group (Weidimei) and control group (Talcid). The patients were given Weidimei or Talcid both at the dose of 1.0 g 3 times a day for 4 weeks, respectively. The severity of the symptoms including abdominal pain, regurgitation, nausea and vomiting of bile were investigated before and after the treatment. Twenty four hour bile in stomach was monitored. Results The severity of all symptoms greatly decreased after the treatment in two groups ( P

Objective To evaluate the value of ERCP in treating hepatocellular carcinoma complicated with tumor thrombi in bile duct.Methods To analyze retrospectively the results of 15 cases of hepatocellular carcinoma with tumor thrombi in the bile duct including ERBD 8 cases and ENBD 7cases,EMBE after ENBD 4 cases, EST with clearance of tumor thrombi and cytological brush 12 cases, ERCP conjugated with other compositive treatments 9 cases.Results The common feature of cholangiography is filling defect in the bile duct as the so called "tennis bat" sign and "flocculation" sign, 13 cases have got drainage successfully after ERCP with the effective rate 86 7%, Satisfactory results were obtained in patients received ERCP conjugated with other compositive treatments.Conclusion ERCP is very important treatment of hepatocellular carcinoma with tumor thrombi in the bile duct; the "tennis bat" sign and "flocculation" sign were the very important evidences of tumor thrombi in the bile duct. If combined with other compositive treatment such as surgery and TAE, ERCP is very effective treatment for the releasing symptoms, improving living quality and prolonging life span in these patients, even in some patients radical cure could be obtained.

Objective:To study the relation between the xenograft survival and IgG, M?, NK,CD4, CD8,MLR testing in peripheral blood of the recipient Methods:By using mouse to rat heart tissue transplantation model,4 experimental groups were established and treated by using: CCV, RPMI 1640(Ⅰ);splenocyte, anti serum with CCV therapy (Ⅱ); splenocyte, anti serum with CsA, Cy, CCV therapies (Ⅲ);splenocyte, anti serum with CsA, Cy, CCV, anti M?, anti NK, anti CD4 and anti CD8 therapies (Ⅳ) The rats received splenocytes (1?10 8) intravenously on the day -12, -8, -4, 0;anti serum (0 2 ml) on the day -10, -6, -2, 0, and CsA 〔10 mg/(kg?d) i p〕, Cy 〔20 mg/(kg?d) i p〕, CCV 〔0 2 mg/(kg?d) i p〕, anti CD4,anti CD8,anti M? and anti NK 〔250 ?g/(kg?d)〕 on the day from 0 to 6 relative to heart grafting on day 0 The graft survival, the IgG, CD4,CD8, M?, NK, MLR were studied Results: On the 7th day after transplantation, grafts in groupⅠwere destroyed, but the grafts in group Ⅱ, Ⅲ, Ⅳ survived well; on the 21st day, only grafts in group Ⅳsurvived well (P

Objective To establish the computer controlled operant behavior test system for rats,and to explore the effects of prenatal exposure to low level methylmercury on the ability of learning and memory in rats Methods The Wistar rats were perorally perfused by 0,0.01,0.05,2.00 mg/(kg?d) methylmercury chloride(MMC) during the period from the 6th day to the 9th day after conception respectively.In every dose group,8 offspring aged 10 weeks were randomly selected to be tested by operant behavior test system.The operant performance was measured in automated nocturnal 15 hour session(16∶00~7∶00).The trial pragram Differential Reinforcement of High (DRH) rate and of low (DRL) rate was carried out by a double blind method.The DRH tests required observed animals to press levers frequently,while the DRL test required the subjects to respect a blocking interval after a reinforcement for pressing lever again. Results The performances scores of 3 exposure groups at doses of 0.01,0.05 and 2.00 mg/(kg?d) methylmercury were significantly lower than that of the control group( P

Objective:To explore the possibility of inducing cell mediated immune response with HSP70 antigenic peptide complex in vitro.Methods:HSP70 peptide complex was reconstituted in vitro.Granulocyte/macrophage colony stimulating factors and interleukin 4 were used to cultivate DC from peripheral blood of HLA A2 positive healthy donors.HSP70,HSP70 peptide complex or peptide was used to activate the DC individually,which will initiate homogenize T lymphocyte to form cytotoxic T lymphocyte(CTL).The cytotxicity of the CTL was detected by MTT assay.Results:It was found that peptide specific CD8 + CTL responses were readily elicited by HSP70 peptide complex or peptide.The CTL response primed by HSP70 peptide complex was more potene than peptide alone.Conclusion:The results suggest that HSP70 peptide complex is immunogenic and HSP70 can lead to great efficient CTL response,antigenic peptides and HSP70 complex may be used as peptide vaccines for cancer immunotherapy.