Objective To investigate the effect of intensive nursing intervention on the secondary infection in chemotherapy of elderly patients with lung cancer.Methods 168 cases of elderly lung cancer patients whose neutrophil ≤ 1.0×109/L during chemotherapy were randomly divided into two groups,namely,the intensive care group and the control group,with 84 cases in each group.The control group was given routine nursing of infection prevention,while the intensive care group was given intensified nursing for infection prevention.A contrastive analysis was conducted in terms of the incidence,clinical characteristics and the duration of antibiotic treatment of the two groups of patients with secondary infection.Results The secondary infection rate of the intensive care group was lower than that of the control group during chemotherapy.What's more,the duration of fever and treatment of the intensive care group was shorter than that of the control group,hence the patients were safe during infection period.The difference was statistically significant.Conclusions Strengthening the nursing intervention can reduce the incidence rate of secondary infection in aged patients with lung cancer,increase the tolerance of patients to chemotherapy and ensure the successful completion of the chemotherapy cycle,prolong the life span of the patients with an improved quality of life.

Objective:To discuss the value of ultrasonography in the diagnosis and differential diagnosis of inguinal masses in children. Methods:Five hundred and eighty-two patients were examined by ultrasonography,and the sonogram features were observed. Results:The feature of sonogram of majority cases were distinctive,which were can be separated into three kinds as spina bifida cystica,parenchymatous and hyperechogenicity. Conclusion:The ultrasonic examination should be used as the regular differential diagnostic method for inguinal masses in children.

Objective To investigate the CT features of active pulmonary tuberculosis.Methods The clinical data and HRCT in 79 patients with histologically proved active pulmonary tuberculosis were studied retrospectively.The diagnosis of active pulmonary tuberculosis was based on positive acid-fast bacilli in sputum (43 patients) and the features at the serial radiographs obtained treatment period(36 patients).Results The main CT finding of active pulmonary tuberculosis were centrilobular nodules in 65 cases(82.3),tree in bud appearance in 65 cases(82.3),thickening of bronchial wall in 58 cases(73.5), consolidation in 61 cases(77.3), cavity in 56(73.2), fluid-bronchogran in 53cases(72.8),ground-grass sign in 45 cases(56.8),line shadows in 55 cases(73.1),pleural thickening in 21 cases (26.6), hilar and mediastinal adenopathy in 12 cases(15.1) and more two abnormal findings co-existed in 79 cases.The centrilobular nodules (n=25) ,tree in bud appearance (n=26) ,thickening of bronchial wall(n=8), consolidation (n=19) and ground-grass shadows (n=21) were improved after therapy .Conclusion The active pulmonary tuberculosis are of some specific HRCT manifestations,which may be helpful to improve the dignosis combined with other clinical formation.

Cytokines of the transforming growth factor (TGF-?)family exert multiple biological effects by their signal transduction pathways that undergo a basic course of ligands of TGF-? family→receptors→SMADs→transcription factors→DNA expression. The genetic variety of different signal molecules in transduction pathways of TGF-? family were found in various benign or malignant tumors, and this had much significance in designing effective therapeutic strategy.

Objective To explore the expression level and clinical significance of microRNA‐451 (miR‐451) in the plasma of patients with diffuse large B lymphoma (DLBCL) .Methods We enrolled 27 patients with DLBCL and 27 healthy controls for the study .The plasma level of miR‐451 was detected by reverse transcription polymerase chain reaction (RT‐PCR) .Then we analyzed the relationship between the plasma level of miR‐451 and pathological characteristics of DLBCL .Results The plasma level of miR‐451 in the patients with DLBCL was significantly lower than in healthy controls [(0 .41 ± 0 .15) vs .(0 .64 ± 0 .21)] (P<0 .01) .However ,the plasma level of miR‐451 was not significantly correlated with the patients'gender ,age ,serum LDH level or primary site (P>0 .05) ,but with Ann Arbor tumor stage and IPI score ( P< 0 .05 ) .Conclusion The plasma level of miR‐451 decreases in patients with DLBCL ,which indicates that miR‐451 may participate in the pathology of DLBCL .

OBJECTIVE:To analyze the utilization and cost of three kinds antibiotics in patients undergoing coronary artery bypass graft (CABG). METHODS:Eight four CABG patients were divided into three groups:Mezlocillin Sodium group (n=28),Cefuroxime Sodium group (n=28) and Ciprofloxacin group (n=28). The postoperative infection rate,changes in body temperature WBC count and the cost of antibiotics were compared among the 3 groups. RESULTS:No postoperative infection case was noted in all the 3 groups. The duration for breathing machine used in Cefuroxime sodium group was the shortest at (14.21?5.45) hours,and the average cost for antibiotics in this group was also the lowest at (678.28?256.74) yuan,showing significance as compared with the other two groups (P

0.05). Conclusion:Accurate working length may be obtained with RootZX electronic apex locator.

Objective:To investigate the mechanism of ~(131)I-GM-CSF inducing apoptosis of HL-60/ADM cells.Methods:An in vitro radioimmunotherapy(RAIT) model was employed.Data were collected from transmission electrion microscopy,flow cytometric analysis and immunocytochemistry assay.Results:After exposure to ~(131)I-GM-CSF,HL-60/ADM cells were induced to apoptosis.The cell mitochondrial transmembrane potential(MTP) reduced and HL-60/ADM cells appeared the classical apoptotic morphology.The Bax was up regulated,while Bcl-2 and Bcl-xl was decreased.Conclusion:~(131)I-GM-CSF can induce HL-60/ADM apoptosis through opening the mitochondrial permeability transition pore and reducing MTP,which suggests that ~(131)I-GM-CSF may be available in therapy of AML.

OBJECTIVE:To observe the clinical efficacy of Xuebijing injection for hemorrhagic fever with renal syndrome(HFRS) complicating acute renal failure(ARF). METHODS:A total of 72 patients with HFRS complicating ARF were randomly assigned to receive combined therapy of western medicines(control group,n=30) or combined therapy of western medicines in combination with Xuebijing injection(trial group,n=42). RESUTLS:There were significant differences between the trial group and the control group in total effective rate (95.24% vs.80.00%) (P

BACKGROUND: A considerable number of epilepsy patients cannot be treated sufficiently by drug. Epilepsy surgery is a treatment option in these cases. However, precisely localizing epileptogenic zone in epileptic patients is a successful element of epilepsy surgery. Its goal is to remove a minimum volume to control the seizures without cognitive impairment. Presurgical evaluation typically involves electroencephalogram (EEG), video-EEG monitoring, magnetic resonance imaging (MRI), single photon emission computed tomography and neuropsychological testing. Magnetoencephalography (MEG) has been as a noninvasive technique to be used to epilepsy surgical planning and brain functional study in many countries.OBJECTIVE: To preoperatively localize epileptogenic zone in patients with lesion-associated epilepsy using magnetoencephalography, compare with noninvasive video-EEG, and assess its localizing value according to the surgical outcomes. DESIGN, TIME AND SETTING: A retrospective case analysis was performed at the Magnetoencephalography Laboratory, Guangdong 999 Brain Hospital, China between November 2001 and December 2005.PARTICIPANTS: A total of 618 epileptic patients undergoing magnetoencephalography. Spontaneous magnetic field signal was collected to analyze single dipole location. Of them, 149 patients with MRI-documented epilepsy underwent surgery. The history of disease was at least 2 years. The course of disease ranged 2-35 years, with an average of 9.5 years. METHODS: MEG was recorded by a 148-channels whole head type MEG system (Magnes WH2500, 4-D Neuroimaging, San Diego, CA, USA) in Magnetically Shielded Room (MSR, Germany). Sampling rate: 508.63 Hz, 30-minutes interictal MEG (Bandpass: 1.0-100 Hz). For magnetic source imaging, the nasion and preauricular points were applied as fiducials. Single equivalent current dipole (ECDs) and head sphere model were applied for analysis. Estimated ECDs were overlaid on T1-weighted MRI of each subject.MAIN OUTCOME MEASURES: Preoperative MEG, MRI, and video-EEG and postoperative follow-up were measured. RESULTS: The sensitivity of the interictal MEG for detecting epileptiform activity was found in 91% of the patient. In most cases, the equivalent dipoles were mainly distributed over the border and neighborhood of the structural lesions. By MEG, we were able to localize the resected region in a greater proportion of patients (62.4%, 93/149) than with noninvasive vedio-EEG (38.9%, 58/149) in all patients with MRI-documented lesions. A total of 89 patients were followed up from 3-35 months, averagely 9 months. Of the 89 patients, 72 patients (80.9%) had no postoperative seizures (EngelⅠ); 7 (7.9%) cases obtain Engel Ⅱ and Engel Ⅲ outcomes. Favorable outcomes were not seen in 10 patients (11.2%) cases (Engel Ⅳ and Engel Ⅴ). Total effective rate was 88.8% (EngelⅠ-Ⅲ). CONCLUSION: MEG is not only most useful for presurgical planning in epilepsy patients with MRI-documented lesions, but is also a noninvasive method to identify the spatial relationship between the lesion and epileptogenic zone, a precise localization of the epileptogenic zone is correlated to a favorable outcome.