Painful leg ulcers are very common in clinic,including arterial ulcers,venous ulcers,autoimmune diseases-related ulcers,gangrenous pyoderma,necrobiosis lipoidica and hypertensive ulcers.At present,few painful leg ulcer-related researches have been conducted in China,and pain is only treated as a concomitant symptom of leg ulcers.However,a series of painful leg ulcer-related researches have been carried out in other countries.This review comprehensively expounds the definition,epidemiological characteristics,etiology and management of,as well as pain mechanism and assessment in painful leg ulcers.