Patients with HER-2-positive advanced breast cancer were associated with poor prognosis. Meanwhile, HER-2-targeted ther-apy has dramatically improved survival and prognosis among breast cancer patients. Over the years, multiple HER-2-targeting drugs stepped into clinical practice, and the targeted agents are now considered as the standard of care in the first-line setting and beyond. This review basically summarizes the importance of HER-2-targeted therapy, the significance of the clinical trial results, and the clinical practice guidelines for the management of patients with HER-2-positive advanced breast cancer.

Objective: To study the stability of forsythiaside. Methods: The stability of forsythiaside was studied by using UV spectrum obsiving the changes of spectrums in different conditions. Results: Forsythiaside was very unstable under the condition of alkali (pH=9.40), relatively stable at the pH=6.86, 60?Cand stable at the pH= 4.03 . Conclusion: The stability of forsythiaside can be affected by the condition of the acid, alkali and temperatures obviously.

The optimal treatment of elderly women with breast cancer still faces many difficulties. Life expectancy, comorbidity, and functional status influence clinical decision and survival. Standard adjuvant medical treatments should not be withheld from healthy older patients with reasonable life expectancies. In this study, adjuvant medical treatment literatures for elderly breast cancer patients, including endocrine therapy, chemotherapy, and HER2-targeted therapy, were reviewed, focusing on efficacy and toxicity of drugs for elderly women.

Adult ; Aged ; Aged, 80 and over ; Antineoplastic Agents ; adverse effects ; therapeutic use ; Brain Neoplasms ; secondary ; Carcinoma, Non-Small-Cell Lung ; drug therapy ; secondary ; Exanthema ; chemically induced ; Female ; Humans ; Liver Neoplasms ; secondary ; Lung Neoplasms ; drug therapy ; pathology ; Male ; Middle Aged ; Neoplasm Staging ; Protein Kinase Inhibitors ; adverse effects ; therapeutic use ; Quinazolines ; adverse effects ; therapeutic use ; Remission Induction ; Survival Rate ; Vomiting ; chemically induced

Objective To explore the clinical and CT characteristics of extreme lateral lumbar disc herniations and improve the diagnosis. Methods A retrospective analysis of the clinical and CT manifestations in 15 patients with extreme lateral lumbar disc herniations proved by operation was done. Results Extreme lateral lumbar disc herniation at L4/5 level is more common. Intraforaminal lumbar disc herniations combined with extraforaminal herniation were seen in most cases. The clinical findings often presented lumbar bi-root compression syndromes. Conclusion The clinical presentation combined with CT image is the key to the correct diagnosis.

The review is focused on the development and recent research of the first tissue-specific angiogenic molecule,endocrine gland-derived vascular endothelial growth factor(EG-VEGF).It has been found that EG-VEGF only targeted on steroidgenic endocrine organs or cells through G-protein coupled receptor,the phosphorylation of G-protein coupled receptor could activate mitogen-activated protein kinase p44/42 and phosphatidylinositol-3 kinase(PI3K) pathways signal transdution.There are many reports that believes MAPK and PI3K is involved in the regulation of proliferation,migration,survival of endothelial cells and tumor angiogenesis,so EG-VEGF may serve as a potential target for antiangiogenic therapy of cancer in the future.

AIM: Human herpesvirus 6B(HHV-6B) is the etiologic agent of exanthem subitum and is associated with febrile illnesses in children, neurological manifestations during primary infection, and clinical complications in organ transplant patients. The ORF U83 of HHV-6B has been identidied encoding a functional chemokine and U83 protein was detected out in brain tissues of some patients with multiple cirrhosis. The aim of this study was to establish HHV-6B U83 transgenic mouse lines, which would provide a pathological animal model for the research of the relationship between HHV-6B U83 gene and multiple cirrhosis. METHODS: Transgenic animal technique was applied in the present study. RESULTS: We successfully established 3 lines of transgenic mice with HHV-6B U83 gene integrated to their chromosomes, through constructing the DNA fragment which consisted of GFAP promotor, HHV-6B U83 and mouse protamine 1 sequence and injecting to the mouse eggs. CONCLUSION: This establishment of HHV-6B U83 transgenic mouse lines would benefit the observation and analysis of association of HHV-6B infection with neurological system diseases.

Inflammatory bowel disease(IBD),the precise etiology of which remains unknown,is comprised of two forms of chronic intestinal inflammation,ulcerative colitis and Crohn's disease.Recent researches suggest that angiopoiesis plays an important role in the development of IBD.Many cytokines can enhance angiopoiesis,such as fibroblast growth factor-2,interleukin-8,platelet-derived growth factor,transforming growth factor-? and particularly vascular endothelial growth factor.This review summarizes the angiopoietic factors correlated with IBD.

Objective To investigate the effects of Irbesartan on endothelial function and autonomic nervous system activity of patients with essential hypertension. Methods The endothelium dependent flow mediated dilatation (F-MD) and the endothelium independent nitroglycerin mediated dilatation (NTG-MD) were evaluated by the brachial ultrasound examination. Time-domain indices of heart rate variability (HRV) were measured by 24 h ambulatory electrocardiogram. The changes of blood lipoproteins, blood glucose, insulin levels, endothelial function and heart rate variability in 60 patients with mild-moderate essential hypertension and 20 healthy controls were compared, and the effects of different antihypertensive agents (AT1 receptor blocker and diuretic) for 8-week treatment were observed. Results Endothelial dysfunction and abnormal autonomic nervous activity were observed in patients with mild-moderate essential hypertension as follow: mildly decreased total HRV and mildly increased 24-hour average heart rate, significantly decreased parasympathetic tone-rMSSD and PNN50, obviously lowered endothelium dependent F-MD. The postprandial insulin level and insulin/glucose ratio of patients with hypertension was significantly higher than that of healthy controls. The decreased blood pressure level caused by AT1 receptor blocker (Irbesartan) and diuretic (Indapamide) was similar. Irbesartan for 8-week therapy resulted in a significant improvement of the endothelium dependent F-MD and insulin resistence, the increase of vagal nervous activity and the decrease of 24-hour average heart rate, but Indapamide presented no such effects. Conclusion This study suggested that patients with mild-moderate essential hypertension have significantly abnormal endothelial function and autonomic nervous activity, and the beneficial effect of Irbesartan is associated with an improvement of insulin resistence and heart rate variability, not with the decrease of blood pressure level.

Objective To investigate the effects of S-adenosylmethionine (SAM) on ethanol-induced liver injury in rats. Methods 48 female SD rats were randomly divided into 4 groups as control, model, small and large dose SAM groups. Except control group, all rats were fed high fat-containing diet plus ethanol and fish oil gavage for 8 weeks. SAM was administered by intraperitioneal injection after 4 weeks of exposure to ethanol. Plasma total homocysteine (tHcy), serum aminotransferase activity (ALT), liver malondialdehyde (MDA), glutathione (GSH) contents were assayed, and expression of TNF-? was detected by immunohistochemistry, and liver histology was also examined. Results Compared with control group, model group rats developed marked liver damage, accompanied by an increase of tHcy, ALT, and MDA levels, but a decrease of GSH levels (P0.05). Conclusion SAM prevents alcohol-induced liver injury in rats by reducing liver lipid peroxidation, together with down-regalation of expression of TNF-?. SAM does not affect the plasma total homocysteine levels.