Stroke is a complex disease and one of the main causes of morbidity and mortality among the adult population. A huge variety of factors is known to influence patient outcome, including demographic variables, comorbidities or genetics. In this review, we expound what is known about the influence of clinical variables and related genetic risk factors on ischemic stroke outcome, focusing on acute and subacute outcome (within 24 to 48 hours after stroke and until day 10, respectively), as they are the first indicators of stroke damage. We searched the PubMed data base for articles that investigated the interaction between clinical variables or genetic factors and acute or subacute stroke outcome. A total of 61 studies were finally included in this review. Regarding the data collected, the variables consistently associated with acute stroke outcome are: glucose levels, blood pressure, presence of atrial fibrillation, prior statin treatment, stroke severity, type of acute treatment performed, severe neurological complications, leukocyte levels, and genetic risk factors. Further research and international efforts are required in this field, which should include genome-wide association studies.
Adult ; Atrial Fibrillation ; Blood Pressure ; Comorbidity ; Genetics ; Genome-Wide Association Study ; Glucose ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Leukocytes ; Mortality ; Risk Factors ; Stroke

Introduction: The maturation process of peloids has been the subject of many studies over time. Knowledge of the processes occurring during this time period, it is very interesting to know the applications of the final product. Material and Method: For preparation of extemporaneous peloids it has been used clay Bentonite Volcangel (Benesa) supplied by Süd Chemie, a mineral water hyperthermal (42°C), sulphurated, weak mineralization (261 mg/l) from Baños Montemayor (M) and water purified obtained by distillation and ion exchange (A).   Peloids were prepared by mixing in the ratio needed aiming to produce a product with 70% water and clay, in polymeric material containers. Water and clay were mixed slowly until total homogenization. The product was introduced into glass containers tightly closed and kept at a constant temperature of 42°C and 8°C.   The percentage of the solid components, water and ashes was determined by gravimetric techniques, drying the sample in oven and muffle furnace (850°C). The specific heat and calorific retentivity were calculated from these data.   　Every six weeks, the analysis of all parameters are repeated in samples maintained at 42°C and 8°C to study possible variations. Results: In Table 1 are shown values of the parameters of the initial peloids prepared with purified water and mineromedicinal water. Conclusion: There were no significant differences observed in the values of the analyzed parameters between the two initial peloids prepared with purified water and with medicinal mineral water of Montemayor spa and a slight diminution in the water percentage, and a small increase of the relaxation time six weeks later.