No abstract available.
Hernia*

We have cloned a alpha-COP homolog, ancop, from Aspergillus nidulans by colony hybridization of chromosome specific library using alpha-COP homologous fragment as a probe. The probe DNA was amplified with degenerated primers designed by comparison of conserved region of the amino acid sequences of Saccharomyces cerevisiae alpha-COP, Homo sapiens HEP-COP, and Drosophila melanogaster alpha-COP. Full length cDNA clone was also amplified by RT-PCR. Comparison of genomic DNA sequence with cDNA sequence obtained by RT-PCR revealed 7 introns. Amino acid sequence similarity search of the anCop with other alpha-COPs gave an overall identity of 52% with S. cerevisiae, 47% with human and bovine, 45% with Drosophila and Arabidopsis . In upstream region from the transcription start site, a putative TATA and CAAT motif were also identified.
Amino Acid Sequence ; Arabidopsis ; Aspergillus nidulans* ; Aspergillus* ; Base Sequence ; Clone Cells ; Coatomer Protein* ; DNA ; DNA, Complementary ; Drosophila ; Drosophila melanogaster ; Humans ; Introns ; Saccharomyces cerevisiae ; Sequence Homology ; Transcription Initiation Site

We found an error in this article. The author's affiliation.

BACKGROUND: Totally implantable access port (TIAP) provides reliable, long term vascular access with minimal risk of infection and allows patients normal physical activity. With wide use of ports, new complications have been encountered. We analyzed TIAP related complications and evaluated the outcomes of two different percutaneous routes of access to superior vena cava. METHODS: All 172 patients who underwent port insertion with internal jugular approach (Group 1, n = 92) and subclavian approach (Group 2, n = 79) between August 2011 and May 2013 in a single center were analyzed, retrospectively. Medical records were analyzed to compare the outcomes and the occurrence of port related complications between two different percutaneous routes of access to superior vena cava. RESULTS: Median follow-up for TIAP was 278 days (range, 1-1868). Twenty four complications were occurred (14.0%), including pneumothorax (n = 1, 0.6%), migration/malposition (n = 4, 2.3%), pinch-off syndrome (n = 4, 2.3%), malfunction (n = 2, 1.1%), infection (n = 8, 4.7%), and venous thrombosis (n = 5, 2.9%). The overall incidence was 8.7% and 20.3% in each group (p = 0.030). Mechanical complications except infectious and thrombotic complications were more often occurred in group 2 (p = 0.033). The mechanical complication free probability is significantly higher in group 1 (p = 0.040). CONCLUSIONS: We suggest that the jugular access should be chosen in patients who need long term catheterization because of high incidence of mechanical complication, such as pinch-off syndrome.
Catheterization ; Catheters ; Follow-Up Studies ; Humans ; Incidence ; Jugular Veins ; Medical Records ; Motor Activity ; Pneumothorax ; Retrospective Studies ; Subclavian Vein ; Vascular Access Devices ; Vena Cava, Superior ; Venous Thrombosis

PURPOSE: It is now well established that infection and inflammation play an important role in the pathogenesis of ischemic brain damage. The loss of neutrophils from systemic circulation is an associated finding in injury mediated by granulocyte. Periventricular leukomalacia(PVL) caused by ischemia is the principal form of brain injury in premature infants. This study was conducted to evaluate whether the low neutrophil count is associated with periventricular leukomalacia(PVL) in premature infants. METHODS: Retrospective review of medical records was undertaken. Subjects were premature infants with a birth weight of less than 1,500 gm, admitted to the Neonatal Intensive Care Unit of Kyungpook University Hospital. A complete blood count of peripheral blood was done within the 1st hour of life. Neutropenia was defined as absolute neutrophil count <1,500/mm3, PVL as increased periven tricular echodensities followed by cyst formation on ultrasonography or corresponding signs on brain MRI. RESULTS: Thirteen infants out of a total population of 37 revealed neutropenia. Respiratory distress syndrome and requirement for respiratory support were not different between infants with neutropenia(neutropenia group) and infants without neutropenia(control group). Intraventricular hemorrhage (IVH) and grade 3 and 4 IVH were more frequent in neutropenia group(P<0.05). There was no statistically significant increase of PVL in neutropenia group. The neutrophil count was 18,760.0+/-10,266.1/mm3, 7,272.0+/-7,435.0/mm3 infants with PVL and 11,131.7+/-3,386.5/mm3, 2,407.5+/-1,933.1/mm3 in infants without PVL, respectively. The frequency of mechanical ventilation and artificial surfactant therapy was higher in infants with PVL compared with infants without PVL, but statistical analysis was not performed due to small number of subjects. CONCLUSION: A low number of neutrophils in the systemic circulation was not associated with an increased risk of PVL in premature infants.
Birth Weight ; Blood Cell Count ; Brain ; Brain Injuries ; Granulocytes ; Gyeongsangbuk-do ; Hemorrhage ; Humans ; Infant ; Infant, Newborn* ; Infant, Premature ; Inflammation ; Intensive Care, Neonatal ; Ischemia ; Leukomalacia, Periventricular* ; Magnetic Resonance Imaging ; Medical Records ; Neutropenia ; Neutrophils* ; Respiration, Artificial ; Retrospective Studies ; Ultrasonography

No abstract available.

No abstract available.
Nasal Cavity* ; Solitary Fibrous Tumors*

Acute autonomic and sensory neuropathy (AASN) is a rare neuropathy characterized by the acute onset of autonomic dysfunction and objective sensory disturbances. A 33-year-old woman experienced generalized fatigue, urinary retention, and defecation difficulty with numbness around her mouth followed by a decreased pain sensation over her face and whole body, and respiratory difficulty with aspiration pneumonia. Neurological examination revealed bilaterally dilated fixed pupils, loss of sweating and lacrimation, orthostatic hypotension, and decreased sensation of all modalities with transient mild to moderate motor weaknesses. The muscle weakness may have been responsible for her respiratory failure as her respiratory distress was resolved in conjunction with improved general muscle power. Although the pathogenetic mechanism of AASN has been generally believed to be immune-mediated, the absence of immunoglobulin responsiveness and the negative results to various autoantibody tests in our case, raises questions against its autoimmune etiology. The patient showed slow progress of overcoming her autonomic dysfunction with relatively persistent sensory deficits.
Adult ; Defecation ; Fatigue ; Female ; Humans ; Hypesthesia ; Hypotension, Orthostatic ; Immunoglobulins ; Mouth ; Muscle Weakness ; Neurologic Examination ; Pneumonia, Aspiration ; Pupil Disorders ; Respiratory Insufficiency* ; Sensation ; Sweat ; Sweating ; Urinary Retention

Macropsia is a rare disorder of visual perception characterized by the perception of a definite increase in the size of objects. We report a 64-year-old man who presented with left hemimacropsia and left homonymus upper quadrantanopsia. A brain MRI showed a high intensity signal in the right lingual gyrus and fusiform gyrus including the Brodmann area 18 on the T2WI and DWI. Brain MRA showed occlusion of the right proximal PCA. This lesion was mainly in the posterior part of the ventral occipitotemporal visual pathway.
Brain ; Hemianopsia ; Humans ; Infarction, Posterior Cerebral Artery* ; Magnetic Resonance Imaging ; Middle Aged ; Passive Cutaneous Anaphylaxis ; Posterior Cerebral Artery* ; Vision Disorders* ; Visual Pathways ; Visual Perception

Corneal endothelial degeneration has been reported in diseases associated with CAG repeat expansion including spinocerebellar ataxia type 1 (SCA1) and dentatorubropallidoluysian atrophy (DRPLA). We report a 35-year-old man who has cerebellar ataxia, myoclonic seizure, dystonia, chorea, mental retardation, and visual disturbance. Detailed ophthalmologic examination showed marked reduction of the corneal endothelial cell density. Genetic analysis revealed the presence of a pathological CAG expansion within the DRPLA gene. We suggest that corneal endothelial degeneration might be one of the signs differentiating DRPLA from other hereditary ataxias.
Adult ; Atrophy* ; Cerebellar Ataxia ; Chorea ; Dystonia ; Endothelial Cells ; Humans ; Intellectual Disability ; Seizures ; Spinocerebellar Ataxias ; Spinocerebellar Degenerations