Objective: To investigate the clinical value of peripheral blood neutrophil to lymphocyte ratio ( NLR) in patients with acute respiratory distress syndrome, and to compare the role of NLR and procalcitonin ( PCT) in the prognosis of patients with acute respiratory distress syndrome. Methods: From October 2015 to December 2017, 79 cases of ARDS patients were selected as case group, and 79 health examination persons were also selected as control group. According to the situation of death in 28 days of the ARDS patients were divided into survival group ( 38 cases) and death group ( 41 cases). The peripheral blood white blood cell count ( WBC), neutrophils count ( NC), lymphocyte count ( LC) and serum PCT level were detected, and calculate NLR. The clinical value of NLR and PCT in patients with acute respiratory distress syndrome ( NLR) were evaluated by receiver operating characteristic curve ( ROC) and the area under the curve ( AUC). The Kaplan-Merier method was used to analyze survival rate of patients with ARDS. Results: The levels of WBC, NC, NLR and PCT in ARDS patients were significantly higher than those of the control group ( P＜ 0. 05), while the level of LC was significantly lower than that of the control group ( P＜0. 05). The level of NLR and PCT in the survival group were significantly lower than those in the death group ( P＜0. 05). The AUC of NLR and PCT for evaluating the prognosis of ARDS patients were 0. 786 and0. 689 respectively. With Kaplan-Meier analysis of survival curves, ARDS patients whose NLR ≥13. 80 and PCT ≥ 4. 01 μg/L had lower 28 day survival rate as compared with those with NLR＜13. 80 and PCT＜4. 01 μg/L ( P＜0. 001). Conclusion: The NLR and PCT could be used as biomarkers for evaluating the prognosis of ARDS patients, but the effect of NLR is better than that of PCT.

BACKGROUNDLiquid-based cytology (LBC) offers an alternative method to biopsy in screening endometrial cancer. Cell block (CB), prepared by collecting residual cytological specimen, represents a novel method to supplement the diagnosis of endometrial cytology. This study aimed to compare the specimen adequacy and diagnostic accuracy of LBC and CB in the diagnosis of endometrial lesions.

METHODSA total of 198 women with high risks of endometrial carcinoma (EC) from May 2014 to April 2015 were enrolled in this study. The cytological specimens were collected by the endometrial sampler (SAP-1) followed by histopathologic evaluation of dilatation and curettage or biopsy guided by hysteroscopy. The residual cytological specimens were processed into paraffin-embedded CB after LBC preparation. Diagnostic accuracies of LBC and CB for detecting endometrial lesions were correlated with histological diagnoses. Chi-square test was used to compare the specimen adequacies of LBC and CB.

RESULTSThe specimen inadequate rate of CB was significantly higher than that of LBC (22.2% versus 7.1%, P < 0.01). There were 144 cases with adequate specimens for LBC and CB preparation. Among them, 29 cases were atypical endometrial hyperplasia (11 cases) or carcinoma (18 cases) confirmed by histology evaluation. Taking atypical hyperplasia and carcinoma as positive, the diagnostic accuracy of CB was 95.1% while it was 93.8% in LBC. When combined LBC with CB, the diagnostic accuracy was improved to 95.8%, with a sensitivity of 89.7% and specificity of 97.4%.

CONCLUSIONSCB is a feasible and reproducible adjuvant method for screening endometrial lesions. A combination of CB and LBC can improve the diagnostic accuracy of endometrial lesions.

Adult ; Aged ; Biopsy ; methods ; Cross-Sectional Studies ; Cytodiagnosis ; methods ; Early Detection of Cancer ; methods ; Endometrial Hyperplasia ; diagnosis ; Endometrial Neoplasms ; diagnosis ; Endometrium ; pathology ; Female ; Humans ; Middle Aged ; Sensitivity and Specificity ; Specimen Handling