1.Comparison of Extended-Spectrum beta-Lactamase-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Infection Epidemiology.
Phill Hoon YOON ; Eun Bin CHO ; Su Ji KIM ; Yeon Hee LEE ; Yiel Hea SEO ; Yoon Soo PARK
Korean Journal of Nosocomial Infection Control 2014;19(2):45-51
BACKGROUND: Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli and Klebsiella pneumoniae are main pathogens of bloodstream infection. We compared the epidemiology of ESBL-producing E. coli and K. pneumoniae. METHODS: From January 2003 through March 2007, we retrospectively investigated the clinical characteristics and comorbidities of patients with bloodstream infection by ESBL-producing E. coli and K. pneumoniae. RESULTS: During the study period, 79 patients (54 with E. coli and 25 with K. pneumoniae) with blood cultures positive for ESBL-producing E. coli or K. pneumoniae were studied. When comparing the source of bloodstream infections, urinary tract infections (UTIs) were more commonly caused by E. coli (24% vs. 0; P=0.007), and respiratory tract and soft tissue infection (36% vs. 15%; P=0.04, 12% vs. 0; P=0.03, respectively) were more commonly associated with K. pneumoniae. Among hospital-acquired bloodstream infection, third-generation cephalosporin was more commonly used in patients with E. coli than patients with K. pneumoniae (81% vs. 24%, P<0.001). Medical devices (central venous catheter and urinary catheter) were more commonly used in patients with K. pneumoniae. CONCLUSION: ESBL-producing E. coli bloodstream infection is more common in urinary tract infections. ESBL-producing K. pneumoniae is more common in respiratory tract infections and in skin and soft tissue infections. In hospital-acquired infections, ESBL-producing E. coli bloodstream infection is more common in biliary tract infection. ESBL-producing E. coli was more commonly associated with prior frequent antibiotics use and K. pneumoniae was more commonly associated with use of medical devices.
Anti-Bacterial Agents
;
beta-Lactamases
;
Biliary Tract
;
Catheters
;
Comorbidity
;
Epidemiology*
;
Escherichia coli*
;
Humans
;
Klebsiella pneumoniae*
;
Pneumonia
;
Respiratory System
;
Respiratory Tract Infections
;
Retrospective Studies
;
Skin
;
Soft Tissue Infections
;
Urinary Tract Infections
2.Oxaliplatin-Induced Immune-Mediated Thrombocytopenia: A Case Report.
Hyun Sun WOO ; Kyoung Hwa LEE ; Phill Hoon YOON ; Su Ji KIM ; Inkeun PARK ; Young Saing KIM ; Hee Kyung AHN ; Junshik HONG ; Dong Bok SHIN ; Sun Jin SYM
Cancer Research and Treatment 2015;47(4):949-953
Oxaliplatin is a third-generation platinum derivative used for metastatic or advanced colorectal cancer treatment. Although myelosuppression is the most common cause of oxaliplatin-induced thrombocytopenia, rare cases of oxaliplatin-induced immune-mediated thrombocytopenia are reported. We report a case of a 57-year-old woman with colon cancer who developed gum bleeding and petechiae after oxaliplatin infusion. Laboratory tests revealed grade 4 thrombocytopenia and grade 4 neutropenia. She recovered from the thrombocytopenia and accompanying neutropenia within 4 days with no recurrence following discontinuation of oxaliplatin. Physicians need to be aware of the risk of severe acute thrombocytopenia following oxaliplatin administration.
Colonic Neoplasms
;
Colorectal Neoplasms
;
Female
;
Gingiva
;
Hemorrhage
;
Humans
;
Middle Aged
;
Neutropenia
;
Platinum
;
Purpura
;
Recurrence
;
Thrombocytopenia*