1.A case report of adenoid cystic carcinoma in trachea.
Hee Jae JUN ; Phil Cho CHOI ; See Young HAM ; See Chan SUNG ; Jong Soo WOO
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(6):501-504
No abstract available.
Adenoids*
;
Carcinoma, Adenoid Cystic*
;
Trachea*
2.Surgical treatment of Takayasu's arteritis: report of one case.
Hee Jae JUN ; phil Cho CHOI ; See Young HAM ; See Chan SUNG ; Jong Soo WOO
The Korean Journal of Thoracic and Cardiovascular Surgery 1993;26(6):496-500
No abstract available.
Takayasu Arteritis*
3.A Study on Diagnosis and Treatment of Acute Myocardial Infarction.
Chan Sang PARK ; Jun CHO ; Woo Ik CHOI ; Young Hoo AHN ; Dong Phil LEE
Journal of the Korean Society of Emergency Medicine 1997;8(4):513-519
As the incidence of acute myocardial infarction been increasing with prolongation of life spans, improvement in foods and life styles in Korea, rapid diagnosis and treatment is critical in survival of acute myocardial infarction patient. Most of the acute myocardial infarction result from atherosclerotic plaque forming thrombus and occlusion of coronary artery. Because early thrombolytic therapy is important to maintain the left ventricular function and survival rate, there have been many trials to reperfuse the occluded coronary artery. We have studied the many aspects of acute myocardial infarction such as sex, age, infarction site, chief complaints, change of ECG, change of serum enzyme, time delay on emergency room arrival, and compared the effectiveness of thrombolytic therapy. Total number of patient was 212, and males were 141(66.5%) and females were 71(33.5%). The most common infarction site was ant, fuel wall(102 cases,48%)of the heart and the most common chief complaint was chest pain(204 cases,97%). Among the 106 patients who received thrombolytic therapy, 101 patients(95%) had survived and 5 patients(5%) had died. Among the 64 patients who didn't receive thrombolytic therapy, 56 patients (87.5%) were alived and 8 patients(12.5%) were dead.
Ants
;
Coronary Vessels
;
Diagnosis*
;
Electrocardiography
;
Emergency Service, Hospital
;
Female
;
Heart
;
Humans
;
Incidence
;
Infarction
;
Korea
;
Life Style
;
Life Support Care
;
Male
;
Myocardial Infarction*
;
Plaque, Atherosclerotic
;
Survival Rate
;
Thorax
;
Thrombolytic Therapy
;
Thrombosis
;
Ventricular Function, Left
4.MRI Findings of Intracranial Hemangioblastoma.
Chang Soo KIM ; Seung Kug BALK ; Jong Deok KIM ; Chun Phil CHUNG ; Mee Young CHO ; Sun Sub CHOI
Journal of the Korean Radiological Society 1995;33(5):705-711
PURPOSE: Complete resection of the tumor nodule(mural nodule or solid portion of the tumor) is the essential goal of surgical treatment for heman-gioblastoma. The purpose of this study was to classify the morphologic types of intracranial hemangioblastoma on MRI and to compare the location and contour of tumor nodule on MRI with those on angiography. MATERIALS AND METHODS: The MRI findings of 34 lesions(38 lesions if 4 spinal cord lesions were included) in 26 patients(17 males and 9 females, range of age, 18-67 years, mean, 39 years) with surgically and histopathologically proved intracranial hemangioblastomas were reviewed. Seventeen patients underwent CT scanning in a short interval. Contrast-enahnced T1 -weighted imaging pa- tterns of hemangioblastoma were classified according to Ho's morphologic types. The location and contour of tumor nodule were compared between MRI and angiography in 15 patients(24 lesions). RESULTS: By location, cerebellar hemisphere was predominated(55%), followed by cerebellar vermis(26%), supratentorial region(5%), and medulla oblongata (3%). Spinal cord lesions(11%) were seen in 3 patients of 5 von HippeI-Lindau diseases. The frequency of morphologic types was as follows; Type 1 (purely cystic), 3%, Type 2(mural nodule), 50%, Type 3(cyst with wall enhancement), 3%, Type 4 (cystic nodule), 15%, Type 5(solid with internal cyst), 9%, and Type 6(solid), 20%. All tumor nodules(33 lesions) enhanced intensely with intravenous contrast material on MRI, of which 24 lesions(in 15 patients) revealed hypervascular masses fed by pial arteries on angiography. They were superficial and abutted pia mater partially or in large portion on both MR I and angiography. CONCLUSION: Over 70% of intracranial hemangioblastomas had a surrounding cyst, and superficial, pial-based location and number of the tumor nodules on MRI was correlated well with those on angiography. MRI is the examination of choice for preoperative evaluation of intracranial hemangioblastoma.
Angiography
;
Arteries
;
Female
;
Hemangioblastoma*
;
Humans
;
Magnetic Resonance Imaging*
;
Male
;
Medulla Oblongata
;
Pia Mater
;
Spinal Cord
;
Tomography, X-Ray Computed
5.Evaluation of an ELISA kit for the Serodiagnosis of Pulmonary Tuberculosis by Using Mixed Antigens of Mycobacterium Tuberculosis.
Seung Kyu PARK ; Phil Ho KIM ; Seung Chul KIM ; In Hwan CHOI ; Sun Dae SONG ; Sang Nae CHO
Tuberculosis and Respiratory Diseases 2000;49(5):558-567
BACKGROUND: Recently, serologic techniques for tuberculosis have been developed and some of them, which are focusing on detection of serum antibodies mainly directed against specific 38-kDa Mycobacterium tuberculosis, have already been introduced into the market. In this study, diagnostic significance of a new serologic test(ELISA kit) for pulmonary tuberculosis was evaluated. METHODS: Serologic test with newly developed ELISA kit was performed upon 474 individuals, who include 333 active pulmonary tuberculosis patients, 80 healthy cases, and 61 tuberculosis contact cases. This serologic test was based on the ELISA technique and designed to detect antibodies to mixed complex antigens including 38-kDa, which were developed by Erume Biotech Co.,Seoul.Active pulmonary tuberculosis was diagnosed by sputum AFB smear and culture methods. RESULTS: The seropositivities using this ELISA kit were 82.1% and 73.6% in smear-positive and negative groups among active pulmonary tuberculosis, respectively. And, it also showed that seronegativities were 97.5% and 85.2% in healthy and contact groups, respectively. As a whole, the results of our study suing the ELISA kit as a diagnostic methiod for pulmonary tuberculosis showed 80.0% sensitivity for active pulmonary tuberculosis, 97.5% specificity, 96.1% positive predictive value, and 65.0% negative predictive value when the prevalence of tuberculosis in the samples was 60.1%. CONCLUSION: Our results reveal that the detection of antibody its reaction with 38-kDa antigen of M.tuberculosis is not sufficient to be accepted as single diagnostic method for pulmonary tuberculosis. However, they suggest that ELISA kit may be considered as an adjunctive test to standard diagnostic techniques of pulmonary tuberculosis.
Antibodies
;
Enzyme-Linked Immunosorbent Assay*
;
Humans
;
Mycobacterium tuberculosis*
;
Mycobacterium*
;
Prevalence
;
Sensitivity and Specificity
;
Serologic Tests*
;
Sputum
;
Tuberculosis
;
Tuberculosis, Pulmonary*
6.A Case of Nonsystemic Vasculitic Neuropathy: Electrophysilogic and Pathologic Findings.
Chun Sik KIM ; Keun Ho CHUNG ; Phil Za CHO ; Byuong Cheol CHOI ; Hae Soo KOO
Journal of the Korean Neurological Association 1996;14(4):1018-1022
In nonsystemic vasculitic neuropathy, clinically only nerves are affected : there are no or few constitutional symptoms or serological abnormalities. The clinical and pathological features are those of an ischemic neuropathy caused by a necrotizing vasculitis of small arterioles. This is a case report of nonsystemic vasculitic neuropathy in a 22-year-old male who has the distal symmetric poIyneuropathy as a symptom of localized vsaculitis. The sural nerve biopsy showed a few myelin digestion chamber suggesting axonal degeneration. The patient was treated with steroid daily with gradual clinical and electorophysiological improvement.
Arterioles
;
Axons
;
Biopsy
;
Digestion
;
Humans
;
Male
;
Myelin Sheath
;
Sural Nerve
;
Vasculitis
;
Young Adult
7.CLINICAL ANALYSIS OF THE MUSHROOM POISONING.
Byeong Dae YOO ; Young Ho AHN ; Woo Ik CHOI ; Jun CHO ; Chan Sang PARK ; Dong Phil LEE
Journal of the Korean Society of Emergency Medicine 1998;9(2):323-329
BACKGROUND: Mushroom poisonings are infrequent but potentially fatal. Most fatalities are due to the amatoxin containing species, particularly Amanita phalloides, Amanita virosa, Amanita verna which cause fulminant hepatic failure often with encephalopathy. METHODS: We experienced twenty two patients with acute mushroom poisoning admitted to Dong San hospital, Keimyung University through emergency department between January 1990 and September 1997. RESULTS: Mean age of the patients was 40.0 years and the ratio of male to female was 1 : 0.83. Seasonal distribution is 10 patients in July, 3 in August and 9 in September. The mean interval between ingestion and early symptom onset was 9.7 hours. Most of the patients had early gastrointestinal symptoms; abdominal pain, nausea, vomiting and diarrhea. except for a patient with associated mental change. The subsequent symptoms and signs follow up admission were fulminant hepatic failure(72.7%), renal failure(31.8%), mental change(27.3%), acute pancreatitis(9.1%), pericardial effusion(4.5%) and erythematous rash(4.5%). The outcomes of the patients were recovery(72.7%), death(18.2%) and hopeless discharge(9.1%). CONCLUSION: The patients who have mushroom poisoning are misdiagnosed as having viral gastroenteritis and are discharged frequently. The doctors and people should be educated not to overlook the severity of mushroom poisoning.
Abdominal Pain
;
Agaricales*
;
Amanita
;
Diarrhea
;
Eating
;
Emergency Service, Hospital
;
Female
;
Follow-Up Studies
;
Gastroenteritis
;
Humans
;
Liver Failure, Acute
;
Male
;
Mushroom Poisoning*
;
Nausea
;
Seasons
;
Vomiting
8.A Case of Cerebral Infarction Following Ingestion of Urushiol.
Chun Sik KIM ; Byung Cheol CHOI ; Keun Ho CHUNG ; Phil Za CHO
Journal of the Korean Neurological Association 1996;14(2):650-653
Rhus has been known to one of the most frequent plants which produce allergic contact dermatitis. Allergenic component of thus is urushiol which is composed of catechols with a 15-carbon-atom side-chain. Systemic administration can produced hematogenous contact dermatitis and also severe systemic reactions such as drowsiness, convulsion, nausea, vomiting, glomerulonephritis and urticaria. We experienced a case of right anterior and posterior watershed cerebral infarction, generalized urticaria and allergic contact dermatitis following ingestion of urushiol.
Catechols
;
Cerebral Infarction*
;
Dermatitis, Allergic Contact
;
Dermatitis, Contact
;
Eating*
;
Glomerulonephritis
;
Nausea
;
Rhus
;
Seizures
;
Sleep Stages
;
Urticaria
;
Vomiting
9.Distribution of the Dopamine D1 and D2 Receptor Protein Using Immunohistochemistry in Wistar-Kyoto Rat (WKY) and Spontaneously Hypertensive Rat (SHR) Kidneys.
Se Ho CHANG ; Jong Duk LEE ; Gyeong Jae CHO ; Phil Ok KOH ; Wan Sung CHOI ; Sun Il CHUNG
Korean Journal of Nephrology 1998;17(6):841-852
The kidney and balances of fluid and volume are the basic components of bloocl pressure control, and the kidney is the primary site that initiates the hypertensive process and is affected by hypertensive vascular disease. In the kidney, the dopamine is a potent natriuretic and vasodilating agent, participat- ing in renal sodium excretion and maintenance of cardiovascular homeostasis. And the dopamine receptors in central nervous system and peripheral organs were identified by physiological, biochernical and radioligand binding techniques. Rut previous morphological and biochemical studies have been unable to characterize or determine the tissue distribution of the dopamine receptor subtypes because no selective ligands are available yet. Furthermore, the cellular distribution of the dopamine receptor subtypes in the rat kidney is not demonstrated well. In the SHR, the ability of exogenous and endogenous renal dopamine to engender a natriuresis is impaired. Since renal dopamine levels in genetic models of hypertension are not lower than their normotensive controls, the impaired intrarenal paracrine effect of dopamine in these animal models of hypertension appears to be receptor or postreceptor mediated. And renal dopamine derives mainly from renal tubular dopamine production and to a lesser extent from dopaminergic nerves. The present study utilizes imrnunohistochemistry with specific antibodies to characterize the renal distribution of dopamine receptor subtypes and recognize the role of dopamine receptor defect in the pathogenesis of hypertension in 14-week-old WKY (mean HP 108+/-5mmHg) and SHR (mean RP 174+/-7 mmHg) kidneys. Also it utilizes antibody of tyrosine hyclroxylase (TH) to recognize the site of the dopamine production mediated by TH using light microscopic immunohistochemistry. In the immunohistochemistry of the WKY kidney, dopamine D1 receptor protein is localized to glomerulus, proximal tubule, distal tubule, renal vessels, cortical and medullary collecting duct. And in the SHR kidney, dopamine D1 receptor protein is localized to glomerulus, distal tubule, renal vessels, cortical and medullary collecting duct, and juxtaglomerular apparatus (JGA). But there is no demonstrable positive reaction in the proximal tubule and weakly positive reactions in the renal arterioles of SHR compared with WKY kidney. In the immunohisto-chemistry of the WKY kidney, dopamine D1 receptor protein is localized to glomerulus, proxirnal tubule, distal tubule, renal vessels, cortical and rnedullary collecting duct. And in the SHR kidney, dopamine D2 receptor protein is localized to glomerulus, distal tubule, renal vessels, cortical and medullary collecting duct, and JGA. So, there is no demonstrable positive reaction in the proximal tubule of SHR compared with WKY. In the glomerulus of the WKY and SHR kidneys, both dopamine D1 and D2 receptors are localized. In the in situ hybridization of the WKY and SHR kidneys, dopamine D and D receptors are only demonstrated at the renal vessels. The positive reaction to TH immunohistochemistry of the WKY and SHR kidneys is only observed in the renal medulla compared with negative reaction on the renal cortex. Considering the excretion of sodium up to 65-70% with volume expansion may be mediated by dopamine D1-like receptors in the proximal tubule, our immunohistochemistry findings for the dopamine receptors may support the failure of natriuretic response in the SHR due to an abnormal dopamine receptor. Also our results rnay mean that the glornerular filtration rate is mediated by both dopamine D1 and Dz receptors comparing with the previous studies that the glomerular filtration rate was mediated by dopamine D2 receptor. I'here are some differences in the receptors expressing sites on the previous radioligand binding and pharmacologic studies, but our results suggest that at least some of the renal dopamine DA and DAz receptors correspond structurally to the central dopamine D1 and D2 receptors. Finally the result of TH immunohisto-chemistry suggests that the production of dopamine in the proximal tubule is not mediated by TH.
Animals
;
Antibodies
;
Arterioles
;
Central Nervous System
;
Dopamine*
;
Filtration
;
Glomerular Filtration Rate
;
Homeostasis
;
Hypertension
;
Immunohistochemistry*
;
In Situ Hybridization
;
Juxtaglomerular Apparatus
;
Kidney*
;
Ligands
;
Models, Animal
;
Models, Genetic
;
Natriuresis
;
Rats*
;
Rats, Inbred SHR*
;
Receptors, Dopamine
;
Receptors, Dopamine D1
;
Receptors, Dopamine D2
;
Sodium
;
Tissue Distribution
;
Tyrosine
;
Vascular Diseases
10.A Case of Neonatal Group B Streptococcal Meningitis.
Hyuun Kil YOON ; Phil Joun SONG ; Kyu Chul CHOI ; Chung Hye CHU ; Byoung Soo CHO ; Sa Jun CHUNG
Journal of the Korean Pediatric Society 1984;27(10):1011-1017
No abstract available.
Meningitis*