1.Antihistamine Pretreatment to Reduce Incidence of Withdrawal Movement After Rocuronium Injection.
Ho Jun LEE ; Sung Jin HAN ; Heezoo KIM ; Il Ok LEE ; Myoung Hoon KONG ; Nan Suk KIM ; Sang Ho LIM ; Mi Kyoung LEE
Journal of Korean Medical Science 2009;24(5):879-882
The purpose of this study was to determine the effectiveness of antihistamine therapy for withdrawal movements caused by rocuronium injection. One hundred seventy one ASA I-II adults undergoing elective surgery were randomly assigned to one of two groups. Patients in the control group (Group C) were premedicated with 2 mL normal saline, and those in the antihistamine group (Group A) were pre-medicated with 2 mL (45.5 mg) pheniramine maleate. After the administration of thiopental sodium 5 mg/kg, rocuronium 0.6 mg/kg was injected. Withdrawal movements were assessed using a four-grade scale. The administration of antihistamine reveals lower grade of withdrawal movement after rocuronium injection.
Adult
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Androstanols/*administration & dosage/adverse effects
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Anesthetics, Intravenous/administration & dosage
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Double-Blind Method
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Female
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Histamine H1 Antagonists/*pharmacology
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Humans
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Incidence
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Injections, Intravenous
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Male
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Middle Aged
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Movement/drug effects/physiology
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Neuromuscular Nondepolarizing Agents/*administration & dosage/adverse effects
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Pain/chemically induced
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Pain Measurement
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Pheniramine/*pharmacology
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Thiopental/administration & dosage