A cobalt nanoparticles modified ITO electrode (NpCo/ITO) was prepared by casting cobalt nanoparticles onto ITO electrode and the cobalt nanoparticles were synthesized by NaHB4 reduction. The electrochemical behaviors of adriamycin (ADM) on NpCo/ITO were studied. The modified ITO electrode was characterized by cyclic voltammetry (CV), scanning electron microscopy (SEM) and energy dispersive spectroscopy (EDS). In a 0.01 mol L(-1) PBS (pH 8.0) buffer solution, a sensitive reduction peak of ADM was obtained. A linear relationship is held between the peak current and ADM concentration in the range of 1.0 x 10(-8) - 2.0 x 10(-6) mol L(-1) with detection of 5.0 x 10(-9) mol L(-1)- by cyclic voltammetry (CV) response. The reduction process was irreversible with adsorption at the NpCo/ITO electrode. The modified electrode showed an excellent electrocatalytic activity for the ADM electrochemical reduction.
Antineoplastic Agents ; chemistry ; pharmacology ; Clinical Laboratory Techniques ; Cobalt ; chemistry ; Doxorubicin ; chemistry ; pharmacology ; Electrochemistry ; Electrodes ; trends ; Nanoparticles ; chemistry

No abstract available.
Animal ; Cyclic AMP/metabolism ; Cyclic GMP/metabolism ; Neurotransmitters/physiology ; Pharmacology, Clinical/trends* ; Receptors, Adrenergic/physiology ; Receptors, Drug/physiology* ; Receptors, Opioid/physiology

In the guidance of system theory, using Multidisciplinary technology to study on the combination of Chinese traditional and western medicine, helps to promote fingding the common points between the Chinese traditional and western medicine. In this article, it intends to create mathematical model and analysis of correlation between Chinese medicinal characteristics and neurobehavioral effects based on literature informatics. The numbers of the Chinese medicines with neurobehavioral effects were worked out within the frame work of 'The China Pharmacopeia' of 2005 edition, from the literature publicized since 1980. The correlation and mathematical model were figured outbetween Chinese medicinal characteristics including traditional functional classification, different tastes as well as channel tropism and immunoregulatory activity based on the statistical software SPSS. The results showed that the neurobehavioral effects was related to the qi-invigorating drugs, yang-invigorating herbs, blood-invigorating herbs, resuscitative drugs and kidney meridian herbs, tastes mild of Chinese medicines (P<0.05). It also accords with the theory of 'Kidney produce marrow' of TCM, The coincidencewas 82.8% between mathematical computing and original classification. There are correlations between Chinese medicinal characteristics and neurobehavioral effects. The mathematical model based on these results can be used for studing of neurobehavioral effects and clinical treatment.
China ; Clinical Laboratory Techniques ; Diagnosis, Differential ; Drugs, Chinese Herbal ; pharmacology ; Humans ; Medicine, Chinese Traditional ; methods ; trends ; Models, Theoretical ; Nervous System Diseases ; Statistics as Topic