After conserving by AS-T solution for 42 days, 95% of erythrocytes were remained in good condition and the HGB and HCT indices were still in normal range. Comparison with another erythrocyte conserving solution made by Terumo (Japan) showed that the erythrocytes conserved by AS-T solution were not significant different not only at the beginning but also by 42 days of experiment.
Erythrocytes ; Research ; Solutions ; Pharmaceutical Preparations

Alkaloids ; Chemistry, Pharmaceutical ; Coptis ; Research

Alkaloids ; Chemistry, Pharmaceutical ; Coptis ; Research

There different extract solutions of Kim Ngan Hoa were used in this study. The experimental results showed that: Kim Ngan Hoa has analgesic effect on two experimental models, hotplate and writing test on mice. Beside of analgesic effect, it has significantly acute antiinflammatory effect on rats. The effects of flavonoid and the alcoholic extract are potent than the effects of the water extract. Three extract solutions from Kim Ngan Hoa have also inhibitory effect in vitro the developing of three bacteria: Staphylococcus aureus, E. coli and Pseudomonas aeruginosa. Three preparations from Kim Ngan Hoa have very low acute toxicity
Acute Toxicity Tests ; Research ; Pharmaceutical Preparations ; Toxicity

Introduce nation policy about essential drugs (TTY) in background of nation economic recently. Provide essential drugs ability for people include: produce ability drugs in the fourth essential drugs list, which was promulgated at 28/7/1999 consist of drug list, traditional medicine, providing supplement essential drugs ability from foreign companies. A few proposes and comments of author.
Drugs, Essential ; Pharmaceutical Preparations ; Research Subjects

Standard decoction of medicinal slices has gradually acquired the height of researcher,government and enterprise for approval. And much consensus are increasingly reached. But there are lots of problem needing further discussing.This article summaries the published literature about standard decoction of medicinal slices in recent 3 years. And clarifies the origin of standard decoction of medicinal slices,explain the definition. The study status of standard decoction was reviewed and further analyzed in detail. And then the application fields of standard decoction of medicinal slices are listed. Combined with the research examples of groups,the problem in the study of standard decoction of medicinal slices was discussed. And relevant suggestions are put forward. All this is expected to provide reference in standard decoction research,the quality criterion o of formula granule and study of classical traditional Chinese medicine( TCM) excellent prescriptions.
Medicine, Chinese Traditional ; Pharmaceutical Preparations ; standards ; Research

To establish and validate the design space of the Digeda-4 flavored decoction( DGD-4D) extraction process by using the quality by design( Qb D) concept. With DGD-4D decoction pieces as a model drug,with the transfer rate of aesculin,picroside I,picroside Ⅱ,geniposide and the yield of extract as critical quality attributes( CQAs),the single factor experiment design was used to determine the level of each factor; the Plackett-Burman experiment design was used to select the critical process parameters( CPPs);and the Box-Behnken experiment design was used to optimize the extraction process. The design space of the DGD-4D extraction process was established,and finally,four experimental points were selected to verify the established model. The single factor experiment determined the levels of each factor,including soaking time 60 min and 30 min,water adding volume 12 times and 8 times,extraction time 90 min and 30 min,number of extraction times 3 times and 1 time,as well as extraction temperature 100 ℃ and 90 ℃.By Plackett-Burman experimental design,the DGD-4D water addition,extraction time and number of extraction times were determined to be CPPs. The Box-Behnken experimental variance analysis showed that P of the regression model was less than 0. 01 and the misstated value was more than 0. 01,indicating that the model had good predictive ability,and the operation space of CPPs in the DGD-4D extraction process was determined as follows: the amount of water addition was 10-12 times; extraction time 50-80 min; and number of extraction times was 3 times. The design space of DGD-4D extraction process based on the concept of Qb D is conducive to improving the stability of product quality and laying a foundation for the future development of DGD-4D.
Chemistry, Pharmaceutical ; methods ; Drugs, Chinese Herbal ; chemistry ; Research Design

In recent years, only a small number of new Chinese medicines have been approved for marketing, which has embodied the bottleneck in the development of the Chinese medicine industry. To tackle this problem, the National Medical Products Administration has issued a series of regulations and technical requirements. In the context of new regulations, this study deeply explored the research and development strategies of new Chinese medicines under the guidance of the new classification of drug registration, and discussed the key technical issues in the research and development.
China ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional ; Pharmaceutical Preparations ; Research

Tibetan medicine is an essential part of Chinese medicine and has unique theoretical experience and therapeutic advantages. According to the development principle of inheriting the essence, sticking to the truth, and keeping innovative, the supervision department should give clear and reasonable guidance considering the characteristics of Tibetan medicine, establish a standard system for quality control, clinical verification and evaluation, and accelerate the research and commercialization of new drugs. In view of the needs of drug supply-side reform and the current situation of Tibetan medicine and new pharmaceutical research, we ponder and provide suggestions on the confusion faced by the current supervision of Tibetan drug registration, hoping to contribute to the supervision strategy of Tibetan drug registration and the high-quality development of Tibetan medicine industry.
Tibet ; Medicine, Tibetan Traditional ; Quality Control ; Pharmaceutical Research ; Drug Industry

In this article, the items from 1999 to 2003 of pharmaceutics of Chinese medicine accepted and supported by subject of traditional Chinese medicine, No.9 department of life science, national natural science foundation of China (NSFC) have been reported, in several aspects, such as extracting process, preparation, biopharmaceutics, pharmacokinetic, etc. The problems in these items have also been analyzed briefly.
Biopharmaceutics ; China ; Dosage Forms ; Drugs, Chinese Herbal ; Pharmacokinetics ; Research ; Research Support as Topic ; Technology, Pharmaceutical