The study presented situation of drug-supply and use during past three years and irrational use of antibiotic as well as its causes. This study also introduced intervention measures by remote training on the rational use of antibiotic (via video).
Anti-Bacterial Agents ; education

Drug quality, especially prevention on the false drug that is circulating, has been progressive. However, the antibiotics that was manufactured in the own country, imported and supplied on the market, has not been had high quality, have still remained significant rate under quality standard; This rate is still higher than other drug. Guarantee on the drug quality, which is very necessary, because use well, safely and effectively the antibiotic in treatment will contributed decrease the antibiotic resistance.
Anti-Bacterial Agents ; Pharmaceutical Preparations ; therapeutics

Some unstable secodines 14, 16, 4, 5, stable hydrosecodines 13, 15 ,19, 20, 21, 22, 23 and aspidospermane type compounds 17,18, 9, 10, were prepared. Chemical properties of these compounds were studied by the transformation of stable secodine 13 into unstable secodines 4 and 5, result: vincadifformine 9 and 10 were generated.
Analogs & derivatives ; Alkaloids

31 compounds (mainly sesquiterpenoids) were identified in the composition of the wood oil of Fokienia hodginsii (Dunn) Hery et Thomas, Cupressaceae, of Vietnam. Trans nerolidol (35.0%) and fokienol (25.2%) are the major constituents of the oil. A novel oxygenated sesquiterpen, farnesa-1, 8, 10-trien -3,7-oxide was isolated from the oil, their structure were characterized by MS, 1H- and 13C-NMR. For the first time, the antibacterial and antifungal activity against 15 microorganisms of the oil as well as the isolated sesquiterpenoids trans nerolidol, fokienol and a-cadinol was studied.
Anti-Bacterial Agents ; Antifungal Agents

We have used jacalin, a lectin purified from Vietnamses Jackfruit to design J1- sepharose 4 B affinity column for studying IgA1 concentration from healthy and Hepato Cellular Carcinoma sera. The results obtained showed that IgA1 concentration from human Hepato Cellular Carcinoma serum (7.85+/- 0.80 mg/ml) is 2.76 times higher than that of healthy human (2.84+/-0.28 mg/ml). The use of modified ELISA technique for determination IgA1 concentration from sera indicated the same results in comparison with Affinity chromatography technique.
Immunoglobulin A ; Chromatography

In this study, we have carried out a verification of 3 hyperglycemic models to confirm their potential application and to determine a suitable dose for each hyperglycemic agent. Results from our verification showed that the following hyperglycemic models can be used in screening and evaluating hypoglycemic action of natural products: hyperglycemic action using oral glucoses at 3g/kg. Hyperglycemic action using IM Adrenalin at 0.5 mg/kg. Hyperglycemic action using IV Streptozocin, at 70mg/kg causing human type II diabetes, at 100 m/kg causing human type I diabetes.
Hyperglycemia ; Hypoglycemic Agents ; Pharmaceutical Preparations ; therapeutics

The antifungal activity of 10 vegetable essential oils and 10 traditional medicinal herbs was examined by measuring the minimum growth inhibitory concentration against three groups of fungi: yeast (Cadida albicans), mould (Aspergillus flavus, Aspergillus fumigatus, Aspergillus niger), and dermatophytes (Microsporum gypseum, trichophyton mentagrophytes). The essential oil of Cinnamon and the Alpinia galanga extract showed the strongest effect against all three groups of fungi. The combination effects of Cinnamon essential oil and 3 extracts of traditional medical herbs were determined by the agar dilution method against Candida albicans. The combination of Cinnamon essential oil and A. galanga extract at proportions (1:1) or (3:7) were synergist and the combinations of Cinnamon essential oil and Curcuma longa extract (1:1) or Chrysantherum indicum extract (1:1) were additive.
Antifungal Agents ; Oils, Volatile ; Medicine, Traditional ; Pharmaceutical Preparations ; therapeutics

The coupling procedure of antimalarial agent (SR2) onto polymeric carrier (SR1) by covalent bond (amide linkage) was studied. Some factors of drug coupling reaction was investigated.
Antimalarials ; Pharmaceutical Preparations ; drug therapy

ASLEM is an immuno-stimulant produced by Hanoi college of Pharmacy. Chromosome mutagenicity of ASLEM was evaluated in bone marrow cells and testicular cells of 30 male mice. Male mice were treated with two similar dose of 0,06 mg/day of ASLEM or with saline (control). Chromosome preparations were made 24 h after 2nd injection of ASLEM or saline. 40 metaphases from the bone marrow cells and 20 duskiness metaphases from the testicular cells were analyzed. Frequency of cells with both numerical and structural chromosome aberrations in both bone marrow and testicular cells of ASLEM treated mice showed no significant difference than that found in the control.
Mutation ; Pharmaceutical Preparations ; drug therapy

The azometine derivatives of 5 nitrofurfural remain the biological activities of azometine beside of 5-nitrofurfural actives. Obtained 6 compounds which are crystals with certain melting point and content of elements as estimated formulation have anti fungal and anti microbial activities.
analogs & derivatives ; Pharmaceutical Preparations