Antituberculosis drug-induced hepatotoxicity (ATDH) is common during treatment of tuberculosis. The incidence of PZA-induced hepatotoxicity was substantially higher than that of first line anti-TB drugs. In this study, 11 patients with evidence of antituberculosis drug-induced hepatotoxicity were study. ATDH developed within the first 2 months of the treatment (intensive phase). The common symptoms were fatigue (100%), nausea, vomiting (36%), jaundice (18%). The median transaminase index was 5 for both ALT, AST. Potential of risk factors are age of the patient > 35 (45%), alcoholism (45%), hepatitis B C virus carrier status (27%). Futher studies with large numbers of enrolled patients and control subjects are needed to be conducted in the future
Toxicity ; liver ; Tuberculosis ; Pharmaceutical Preparations

Report one case of a 45 years old male patient lived in Hoc Mon district, Ho Chi Minh City, and admitted in November 24th 2004. His tuberculosis (TB) was first diagnosed in the year 2000 and he was received anti-TB drugs with 2SHR/6HE regime at the anti-TB station. During hospitalization, after 10 days of SHRZE regime (SM 1/2g, Rif 300mg PO, INH 200mg PO, PZA 750mg PO, EMB 600mg PO), he experienced fatigue, dyspnea, jaundice, fever of 39 degree C, blood pressure: 8/5cmHg, SpO2 = 90%. Hematological analysis revealed low hemoglobin and Hct levels, and increase of reticulocyte count and white blood cell count; a positive direct Coombs test. Biochemical tests revealed elevated total, direct and indirect bilirubin levels, increased LDH; decreased haptoglobin; LE cell and ANA were all negative. Patient was diagnosed immune haemolytic anemia and was treated by blood transfusion with the same blood group. He discharged at December 17th 2004 with the last diagnosis was recurrent tuberculosis M(+), rifampicin-induced immune haemolytic anemia
Tuberculosis ; Rifampin ; Therapeutics

Study on 3 cases of splenic tuberculosis with HIV(-), without pulmonary lesions, treated in Pham Ngoc Thach Hospital of Ho Chi Minh city. Among them, the first one might be a single splenic tuberculosis patient, because there was not any lesion in other areas; the second case was glandular tuberculosis combined with splenic tuberculosis; the third case perhaps was splenic tuberculosis combined with symptoms of tuberculous meningitis occurred 15 days after splenectomy. All 3 cases had major symptoms including mild fever and dull pain in left slope lasting from several months to a year. Ultrasound and abdominal computed tomography scan (CT-scan) showed numerous lesions in the spleen with <2cm size and unspecific decreased dark level with or without big spleen, however, dark increased area should be seen in ultrasound. 2/3 cases of splenectomy with pathological results was splenic tuberculosis, one case was not indicated surgery, making biopsy found a glandular tuberculosis. Splenic tuberculosis treatment with regime of anti-tuberculosis drug during 12 months was suitable
Tuberculosis, Splenic ; Case Reports

Report one case of male patient aged 50 years old admitted Pham Ngoc Thach Hospital on August, 23rd 2004 due to allergic reactions with 2 main anti TB rifampicin and isoniazid. He was treated by conventional desensitization to rifampicin and isoniazid. After that, he was treated by formula of 2RHZE/6HE (+ Rifampicin) in 8 months, with good outcomes. X-ray finding on September, 27th 2004 and on May, 27th 2005: pleural effusion decreased and stopped, less pleural adhesion
Tuberculosis ; Therapeutics ; Pharmaceutical Preparations