1.Anti-inflammatory Triterpenes and Glyceryl Glycosides from Kandelia candel (L.) Druce.
Le Duc DAT ; Nguyen Phuong THAO ; Bui Huu TAI ; Bui Thi Thuy LUYEN ; Seo Young YANG ; Sohyun KIM ; Jung Eun KOO ; Young Sang KOH ; Nguyen The CUONG ; Nguyen Hoai NAM ; Nguyen Van THANH ; Phan Van KIEM ; Chau Van MINH ; Young Ho KIM
Natural Product Sciences 2015;21(3):150-154
Phytochemical investigation of Kandelia candel resulted in the isolation of six triterpenes (1 - 5) and two glyceryl glycosides (6 and 7) and their structures were determined by comparing the spectroscopic data with those of reported values. In present study, we described the inhibitory effects of fractions and isolated compounds from K. candel on pro-inflammatory cytokines (IL-12 p40, IL-6, and TNF-alpha) production in lipopolysaccharide (LPS) stimulated bone marrow-derived dendritic cells (BMDCs). Results indicated that compounds 3, 6, and 7 showed potent inhibition on IL-6 production (IC50 values at less than 0.5 microM, respectively). Meanwhile, compounds 6 and 7 exhibited strong inhibitory effects on the production of TNF-alpha (IC50 values of 1.7 +/- 0.1 and 5.5 +/- 0.2 microM). Compounds 1 and 3 were also showed the inhibitory effects on IL-12 p40 production (IC50 values of 8.9 +/- 0.4 and 3.3 +/- 0.1 microM, respectively).
Cytokines
;
Dendritic Cells
;
Glycosides*
;
Interleukin-12
;
Interleukin-6
;
Rhizophoraceae*
;
Triterpenes*
;
Tumor Necrosis Factor-alpha
Result Analysis
Print
Save
E-mail