A control retrospective study included 67 hypertension patients from 18 to 70 years old in Clinical Hospital No 1, Guangzhou Pharmaceutical -Medicine University from 10/200 to 04/2002. Captopril 25 mg/day were given to all patients. The control group included 32 patients. Extract 150ml divided twice daily from malt for 28 days continuously. The study group included 35 patients use "thien ma cau dang am" formulation orally (oral Rhizoma Gastrodiae Ramulus and Uncariae cum Uncis formulation), one packet boiled two times, taken 150ml twice for 28 days continuously. Result: In the hypertension patients with low and moderate risk: Combination of western medicine (Captopril) and traditional medicine (thien ma cau dang am) reduced blood pressure; relieved or prevented symptoms compare to captopril taken alone. Control group: 68.75% compare with study group: 91.43%; p = 0.001. Thien ma cau dang am treat hypertension has better effect than untreatment. It also reduced side effects of Captopril.
Hypertension ; Medicine, Chinese Traditional ; Risk Factors

A controlled prospective study included 50 normal Swiss white mice and 62 patients with mild and moderate hypertension without blood lipid metabolic disorder were divided into two groups randomly. The control group: 31 patients treated by Caporil 25mg, two tablets twice daily, (at 12 hours intervals). The study group: 31 take a TT1 prescription daily within 28 days continuously. The result showed that: No acute toxicity from TT1 prescription on trial dose of white mice: 50g/kg. No side effects occur when the patient uses a TT1 prescription daily. No blood lipid metabolic disorder on mild and moderate hypertension patients. TT1 had clearly good efficacy on hypotension. This efficacy after two weeks treatment is less effective than Caporil 25mg, twice daily but equivalent with Caporil 25mg, twice daily after 4 weeks. Some symptoms such as dazzle, dizziness, headache, red face, red eyes, tightness on chest had improved by TT1 and it was much better than Caporil.
Hypertension ; Lipids ; Blood ; Therapeutics

A study was carried out on 51 patients with hypertension and blood lipid metabolism disorder at the Clinic Department and Heart-Renal-Joint Department in the Military Traditional Hospital and at the General Enterology Department in the Son Tay Hospital from Feb 2004 to Sept 2004. The patients were divided into two groups: study group included 2 patients using a TT2 traditional repice/day for 28 days; control group included 9 patients using Caporil 25mg x 2 tablets/day for 28 days. 50 white mousses of Swiss species were provided by The National Institute of Hygiene and Epidemiology. TT2 experiment showed no acute toxicity with experimental dose 50g/1kg of mouse weight. Boiling and drinking a TT2 traditional repice/day did not cause any side effects. TT2 helps to decrease blood pressure significantly in patients with hypertension and blood lipid metabolism disorder. After 4 weeks, the blood pressure level in patients using TT2 is as equivalent as in patients using Caporil 25mg x 2 tablets/day. TT2 improves symptoms of the both of disease type: dizzy, headache, neck pain, dyspepsia, insomnia, lose appetite, red face, red eyes and constipation.
Hypertension ; Lipids ; Therapeutics

51 hypertension patients with lipidemia disorder were treated at Hospital of Military Traditional Medicine from April to September 2004. All patients were divided into 2 groups: The control group consisted of 19 patients who received Caropil 25mg tablet/ twice a day during 28 continuous days; the study group consisted of 32 patients who received a traditional recipe of TT2/per day divided into 2 times every 12 hours during 28 days. Among hypertension patients with primary lipidemia disorder and signs of phlegm wetness or and phlegm heat types, using a traditional recipe of T22/per day during continuous 28 days had effects of regulating the index of lipidemia: CT decrease of 14.9%; TG decrease of 27.5%; LDL-C decrease of 16.2%; the effects of increasing HDL-C were not significantly (increase of 6.5%).
Hypertension ; Hyperlipidemias

Background: In Vietnam, there are increase rate of patients with acute leukemia including acute myelogenous leukemia. The clinical, gender, age as well as morphological characteristics of cells have prognostic significance about response to treatment and survival time of patients. Objectives: (1) To describe the distribution of acute myelogenous leukemia types by FAB standard in 'National Institute of Hematology and Blood Transfusion. (2) To describe the clinical characteristics of patients with acute myelogenous leukemia. Subjects and methods: The study included 67 patients diagnosed acute myelogenous leukemia by FAB standard without chemotherapy in 'National Institute of Hematology and Blood Transfusion. Results and conclusions: The median age: 35.55 \xb1 13.46, sex: 53% male, 47% female. Ratio of M0, M1, M2, M3, M4, M5, M6, M7 was 1, 10, 19, 18, 30, 13, 6, 1 %, respectively. 100% of these patients presented with anemia, 57 % with hemorrage, 46 % with fever. Lymphadenopathy was presented in 61 %, hepatomegaly was presented in 27% and spleenomegaly was presented in 9%. 53% of the patients had more bleeding was M3. Lymphadenopathy, hepatospleenomegaly had most frequently seen in the patients of M4 and M5 type. \r\n", u'\r\n', u'
Leukemia ; Myeloid ; Acute/ immunology ; Hematology

Background: In recent years, Vietnam has applied four methods (morphology, cell chemistry, immune marker classification, cyto genetic) in diagnosis and used multi-chemotherapy in treatment for acute myelogenous leukemia (AML)\r\n', u'Objectives: To initially determine some fusion gene transcripts in the acute myelogenous leukemia patients by applying PCR technique. Subject and method: The study included 19 patients with acute myelogenous leukemia treated in National Institute of Hematology and Blood Transfusion and Bachmai Hospital from April 2007 to August 2007. RNA were extracted from leukemic cells and PCR for AML1/ETO, CBFP/MYH11, PMR/RARa fusion transcript was done. Results: Number of male patients was 6 (32%), female patients was 13 (68%). The average age of these patients was 32.67 \xb113.62. There were three M4, M4eo patients with AML1/ETO gene (accounting for 16%), two M2, M4 patients with CBF/MYH1 gene and type F of genetic modification accounting for 11%), two M3 patients with PMR/RAR\u03b1 and Bcr3 of genetic modification (accounting for 11%). Conclusion: Results of the study did not differ significantly from other researches in the world. This study showed the need of applying the PCR technique in determining fusion gene transcript together with traditional cyto-genetic method.\r\n', u'\r\n', u'
Leukemia ; Myeloid ; Acute/ blood ; pathology ; complications ; Polymerase Chain Reaction

Background: In Vietnam, there are a number of studies on the application of ATRA in treating acute promyelocytic leukemia (AML \u2013 M3) but they have still faced with certain difficulties. Objectives: (1). Study PML/RAR alpha fusion gene on the patients diagnosed with AML \u2013 M3. (2). Study the index of hematology of the PML/RAR alpha positive group. Subject and Method: 21 patients with acute promyelocytic leukemia (M3) were studied. All patients were examined with morphology, coagulation and cytogenetic tests and RNA were extracted from leukemic cells and PCR for PML/RAR alpha fusion transcript. Result and conclusion: PML/RAR alpha positive in 67% including 4 patients which were not discovered t(15; 17) by cytogenetic technique. Rates of three subtype (bcr1, bcr2 and bcr3) of PML/RAR alpha were 7 patients (50%), 3 patients (21,5%) and 4 patients (28,5%), respectively. WBC and bone marrow cells of PML/RAR alpha positive group were 5.08+/-3.87 and 155.82+/-106.21. D \u2013 Dimer level was 1954.89+/-1575.28; 93% of patients in the PML/RAR alpha positive group had DIC.
Acute promyelocytic leukemia ; M3 ; PML/RAR alpha

Background: Chromosome mutation type t(8;21) has quite a high frequency in acute myelogenous leukemia, which accounted for about 15% among adult patients. From 2001, the WHO has a new classification for acute myelogenous leukemia based on genetic mutations. Form had AML1/ETO were arranged into genetic mutation group with better prognosis and ability to fully recover after chemotherapy with a high dose of cytarabin. Objective: Study AML1/ETO fusion gene on the patients diagnosed with Acute Myelogenous Leukemia (AML), as well as the clinical features and some haematologic parameters of the AML1/ETO positive group. Subject and methods: 76 patients with AML were treating in the National Institute of Hematology & Blood Transfusion and the Department of Hematology & Blood Transfusion of Bach Mai Hospital from April 2007 to July 2008. These patients were studied for clinical examination, morphology and RNA were extracted from leukemic cells and PCR for AML1/ETO fusion transcript was performed. Results and conclusions: The incidence of AML1/ETO positive in the AML patients was 24%. The incidence of AML1/ETO positive in AML-M2 was 28%. In the AML1/ETO positive group: median age was 26.94+/-9.22; rate of severe anemia, hemorrhage, fever, infection, hepatomegaly, splenomegaly, lymphadenopathy and gum hypertrophy was 44%, 33%, 28%, 11%, 44%, 28%, 17% and 6%, respectively. Median hemoglobin, WBC, platelet, bone marrow cell count, % blast in peripheral blood and in bone marrow was 84.41+/-28.97 g/l, 29.42+/-31.36 g/l, 42.12+/-33.83 g/l, 215.93+/-134.42 g/l, 56.21+/-26.58% and 65.14+/-16.12%, respectively.
acute myelogenous leukemia ; AML1/ETO fusion gene

Objective:Highly pathogenic avian influenza A(H5N1) is endemic in poultry in Viet Nam. The country has experienced the third highest number of human infections with influenza A(H5N1) in the world. A study in Hanoi in 2001, before the epizootic that was identified in 2003, found influenza A(H5N1) specific antibodies in 4% of poultry market workers (PMWs). We conducted a seroprevalence survey to determine the seroprevalence of antibodies to influenza A(H5N1) among PMWs in Hanoi, Thaibinh and Thanhhoa provinces.Methods:We selected PMWs from five markets, interviewed them and collected blood samples. These were then tested using a horse haemagglutination inhibition assay and a microneutralization assay with all three clades of influenza A(H5N1) viruses that have circulated in Viet Nam since 2004.Results:The overall seroprevalence was 6.1% (95% confidence interval: 4.6–8.3). The highest proportion (7.2%) was found in PMWs in Hanoi, and the majority of seropositive subjects (70.3%) were slaughterers or sellers of poultry.Discussion:The continued circulation and evolution of influenza A(H5N1) requires comprehensive surveillance of both human and animal sites throughout the country with follow-up studies on PMWs to estimate the risk of avian–human transmission of influenza A(H5N1) in Viet Nam.