. Genetic characteristics of two families having two children with Down's syndrome were analysed in the Department of Medical Biology and Genetics - Hanoi Medical University. Results: Family 1: Couple have two sons with Down's syndrome trisomy 21. Karyotype of the father 46,XY. Karyotype of the mother 46,XY Two sons (5 years and 3 years of old) have karyotype 47,XY,+21. Two sons have single horizontal fold on both hands. Family 2: Couple have a girl and a son with Down's syndrome translocated chromosome t (13;21). Karyotype of the father: 46,XY and of the mother 45,XX,-13,+t(13;21). Karyotype of the girl (12 years): 46,XX, 13,+t(13;21). Karyotype of the son (7 years) have: 46,XY,-13, +t(13;21). Two children have not any single fold on the hands.
Down Syndrome, Child, Genes

Background: many studies showed that obesity rate was significantly higher in women than in men and 60-80% of overweight/obesity caused by diet. Hanoi and Ho Chi Minh City were two of 10 provinces that had the highest rates of obesity. Objectives: to determine the actual rate of overweight/obesity and describe some related factors among Hanoians aged 50-59. Subjectives and Method: a cross sectional survey within a case-control study. The study was carried out in 14 wards under 7 districts of urban Hanoi. Body fat percentage was measured by machine Omron (Japan). Overweight/obesity evaluations were based on classification scales of WHO 1998 and IDI&WPRO 2000. Results: the mean rate of overweight/obesity was 23.1% (26.2% in women vs. 21.9% in men). The rate of women with waist to hip ratio >0.85 (39.83%) was higher than that in male (29.38%). Proportions of body fat percentage greater than 30% were 58.40% in female and 40.06% in male. Overweight/obesity was closely related with sedentary lifestyle, such as spending less time for exercise and sports, high food expenditures, etc. It was found that people with overweight or obese family members were 3 times at risk of overweight/obesity higher /than others. That rates of overweight/obese people with elevated level of biomarkers were composed of 48.99% with high blood cholesterol (>5.2mmol/l); 9.69% with blood glucose (\ufffd?.0mmol/l); especially 65.33% with high triglyceride (>1.7mmol/l); 7.22% with low HDL-C (<1.15 mmol/l); and 8.23% with high LDL-C (\ufffd?.00mmol/l). Conclusions: rate of overweight/obesity among Hanoians aged 50-59 was relatively high. Some related factors were described: waist to hip ratio, body fat percentage, sedentary lifestyle, such as spending less time for exercise and sports, high food expenditures, etc.
Overweight/epidemiology ; Obesity/epidemiology ; Risk Factors ; Middle Aged ;

Objectives: The prevalence of posttraumatic stress disorder (PTSD) has increased, particularly among individuals who have recovered from coronavirus disease 2019 (COVID-19) infection. Health literacy is considered a “social vaccine” that helps people respond effectively to the pandemic. We aimed to investigate the association between long COVID-19 and PTSD, and to examine the modifying role of health literacy in this association. Methods: A cross-sectional study was conducted at 18 hospitals and health centers in Vietnamfrom December 2021 to October 2022. We recruited 4,463 individuals who had recovered from COVID-19 infection for at least 4 weeks. Participants provided information about their sociodemographics, clinical parameters, health-related behaviors, health literacy (usingthe 12-item short-form health literacy scale), long COVID-19 symptoms and PTSD (Impact Event Scale-Revised score of 33 or higher). Logistic regression models were used to examine associations and interactions. Results: Out of the study sample, 55.9% had long COVID-19 symptoms, and 49.6% had PTSD.Individuals with long COVID-19 symptoms had a higher likelihood of PTSD (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.63–2.12; p < 0.001). Higher health literacy was associated with a lower likelihood of PTSD (OR, 0.98; 95% CI, 0.97–0.99; p = 0.001). Compared to those without long COVID-19 symptoms and the lowest health literacy score, those with long COVID-19 symptoms and a 1-point health literacy increment had a 3% lower likelihood of PTSD (OR, 0.97; 95% CI, 0.96–0.99; p = 0.001). Conclusion Health literacy was found to be a protective factor against PTSD and modified the negative impact of long COVID-19 symptoms on PTSD.