292 patients with gestational trophoblastic tumor diagnosed by beta-hCG assay were treated with chemotherapy. The rate of hysterectomy performed before chemotherapy is higher than that during and after chemotherapy. This rate is higher in the group of metastasis subjects than in no metastasis subject group. The rate of single chemotherapy resistance of hysterectomy group is lower in the case of hysterectomy performed before chemotherapy than in the case during and after chemotherapy
Hysterectomy ; Gestational Trophoblastic Neoplasms ; Patients ; Therapeutics

292 patients with mast blastocytoma who were diagnosed after hydatiform pregnancy, after birth and post pregnancy basing on the examinations of beta-HCG, of matastasis and of anapathology, treated till beta HCG < 5 UI/l. According to US classification, the age of the group 1 (non metastasis ligh mast blastocytoma) is younger than group 2 (metastasis severe mast blastocytoma) and in the group 2 the duration from termination of pregnancy to detection of the condition is longer than group 1. In the group of mast blastocytoma of severe prognosis there are an uterus damage of chorion carcinoma, an invasive hydatiform pregnancy. The simple resistance to chemiotherapy is more dramatical in the group 2 than the group 1
Pregnancy ; Pregnant Women ; Women ; Prognosis

Blastomeres; Serum; Pathological Conditions, Anatomical; Chorionic Gonadotropin The group 1 of 75 cases of post molar evacuation and the group 2 of 292 cases of gestational trophoblastic tumors (GTT) were followed up until beta-hCG level serum, determined by IMX, reaches the threshold of < 5 IU/l, there was not any complication after 2 years. There were 7.5% recurrents cases in GTT group, in some cases, beta-hCG reaches 0 UI/l. In the recurrent group, the rate of resistance to the treatment got to 40%, and the rate of resistance to single chemotherapy by MTX got to 30%. 50% of recurrent patients have had uterine histological exams with 36% choriocarcinoma, 4.5% invasive molar
Blastomeres ; Serum ; Pathological Conditions, Anatomical ; Chorionic Gonadotropin

94 women with hydraform mole pregnancy were studied in the Institute of Protection of Mother and Newborn from March 1999 to March 2001. Their beta-hCG levels were evaluated weekly before and after abolition of hydatoform mole, the results were dramatically different. After abolition, the monitoring of beta-hCG curve to detect the mast blastocyte tumors reached a sensivity of 79% and a specificity of 100%. Among the group having complications, the bleeding more prolonged than the groups of no complication of mast blastocyte tumor. Beta-hCG blood level was in safe threshold.
Pregnancy ; Women ; Pregnant Women ; serum ; Chorionic Gonadotropin

Objective: In Viet Nam, tuberculosis (TB) prevalence surveys revealed that approximately 98% of individuals with pulmonary TB have TB-presumptive abnormalities on chest radiographs, while 32% have no TB symptoms. This prompted the adoption of the “Double X” strategy, which combines chest radiographs and computer-aided detection with GeneXpert testing to screen for and diagnose TB among vulnerable populations. The aim of this study was to describe demographic, clinical and radiographic characteristics of symptomatic and asymptomatic Double X participants and to assess multilabel radiographic abnormalities on chest radiographs, interpreted by computer-aided detection software, as a possible tool for detecting TB-presumptive abnormalities, particularly for subclinical TB. Methods: Double X participants with TB-presumptive chest radiographs and/or TB symptoms and known risks were referred for confirmatory GeneXpert testing. The demographic and clinical characteristics of all Double X participants and the subset with confirmed TB were summarized. Univariate and multivariable logistic regression modelling was used to evaluate associations between participant characteristics and subclinical TB and between computer-aided detection multilabel radiographic abnormalities and TB. Results: From 2020 to 2022, 96 631 participants received chest radiographs, with 67 881 (70.2%) reporting no TB symptoms. Among 1144 individuals with Xpert-confirmed TB, 51.0% were subclinical. Subclinical TB prevalence was higher in older age groups, non-smokers, those previously treated for TB and the northern region. Among 11 computer-aided detection multilabel radiographic abnormalities, fibrosis was associated with higher odds of subclinical TB. Discussion: In Viet Nam, Double X community case finding detected pulmonary TB, including subclinical TB. Computer-aided detection software may have the potential to identify subclinical TB on chest radiographs by classifying multilabel radiographic abnormalities, but further research is needed.

Objective: The risk of transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) from schoolchildren to their household and the protective effects of vaccination in these settings remain poorly understood. We assessed the transmission dynamics of schoolchildren with SARS-CoV-2 within their households and the protective effects of coronavirus disease (COVID-19) vaccination among household members in Viet Nam. Methods: We estimated the attack rate, vaccine effectiveness and adjusted risk ratio (aRR) of factors associated with SARS-CoV-2 transmission to household contacts of children confirmed to have COVID-19 who attended three schools in Ha Nam, Phu Tho and Thanh Hoa provinces between September and December 2021 using multivariable regression with household-level random effects. Results: This retrospective cohort study included 157 children infected with SARS-CoV-2 and their 540 household contacts. The attack rate among household contacts was 24.6% (133/540). Overall, vaccine effectiveness among household contacts was 39% (95% confidence interval [CI]: -1 to -63), higher among males than females and higher in adults aged >40 years. COVID-19 transmission was greater among female household contacts compared with males (aRR: 1.35, 95% CI: 0.94 to 1.95), although not statistically significant, and highest among those aged 19–39 years (aRR: 2.51, 95% CI: 1.50 to 4.21). Fully vaccinated household contacts had significantly lower infection risk (aRR: 0.46, 95% CI: 0.26 to 0.84). Discussion: We found substantial onward transmission of SARS-CoV-2 from schoolchildren to household members, and older people were more likely to be protected by vaccination. We recommend that schoolchildren and all household members living with schoolchildren receive at least two doses of a COVID-19 vaccine. Recognizing the role of schoolchildren in the onward transmission of COVID-19 is an important lesson learned by Viet Nam that can help not only in managing other outbreaks but also in protecting schoolchildren by predicting the progress of the outbreak and preparing for a timely response.