1.Research on mortality within 24 hours after admission of child from 1 month to 15 years at Central Hospital of Pediatrics
Journal of Vietnamese Medicine 2005;0(3):22-27
The research was conducted on 213 children from 1 month to 15 years died within 24 hours of admission to the Central Hospital of Pediatrics (CHP) from 1/1/2000 to 30/6/2003 showed that the mortality rate was still high (1.73%). There were some factors affecting to child mortality. Age group 1 month to 12 months accounted 46.01%. The order of the 3 commonest causes of death are respiratory diseases, neurological diseases and infection diseases. The specific causes of death were pneumonia, septicemia, encephalitis, acute encephalitis syndrome. The mortality rate is higher in summer (35.21%), child lived in the countryside over 20km far from the CHP 85,45%. Children were came lately to the hospital, managing themselves at home 55,4%, not managing or managing not correctly 57,28%
Mortality
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Child
2.Preliminary evaluation of the role of biomarkers in diagnosing dementia
Luc Viet Tran ; Thang Pham ; Hung Trong Nguyen ; Binh Thanh Nguyen ; Huong Van Nguyen ; Ngoc Bich Nguyen ; Van Thanh Ta
Journal of Medical Research 2008;56(4):87-91
Background: Dementia is a common pathological condition that affects older people. Most causes of dementia are Alzheimer\u2019s disease and vascular dementia. Diagnosing these conditions mostly relied on clinical patterns, but some biomarkers have been mentioned as the indicators of this condition. Objectives: 1) To evaluate the alteration of some biomarkers in cerebrospinal fluid (CSF) samples from Alzheimer\u2019s patients. 2) To compare the concentration of biomarkers in CSF samples from patients with vascular dementia and Alzheimer\u2019s disease. Subjects and method: Case group involved 41 patients who were diagnosed as AD and vascular dementia based on DSM-IV criteria. 31 matched healthy people were included in control group. All subjects were given neuro-psychological tests and thorough clinical examination. Brain CT scan and MRI were done for both groups. CSF samples were taken from patients in the study group to measure levels of some biomarkers. Results. The levels of total taurine (T-tau) and phosphorylated taurine (P-tau) 181 proteins are higher in the dementia group. The concentration of Abeta-42 is significantly different between case and control groups, but similar between vascular dementia and Alzheimer\u2019s disease patients. Conclusion: Changes in biomarkers are valuable in different diagnosis of Alzheimer\u2019s disease and other types of dementia. However, findings of CSF studies have to be considered with findings from imaging studies and clinical examination.
Biomarker
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Dementia
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Alzheimer\u2019s disease
3.Seroprevalence of Tissue and Luminal Helminths among Patients in Hanoi Medical University Hospital, Vietnam, 2018
Nguyen Van DE ; Pham Ngoc MINH ; Nguyen Ngoc BICH ; Jong-Yil CHAI
The Korean Journal of Parasitology 2020;58(4):387-392
A serological survey was performed using ELISA to estimate the prevalence of tissue and luminal helminthic infections among hospital patients in Hanoi region, Vietnam. An overall seroprevalence of tissue and luminal helminthiases was 64.0% (95% CI 61.2-66.8) among 1,120 patients who visited Hanoi Medical University Hospital, Vietnam in 2018. The highest seroprevalence was observed against Toxocara spp. (59.0%), followed by Strongyloides stercoralis (46.3%), Gnathostoma spp. (25.5%), cysticercus (12.8%), Angiostrongylus cantonensis (10.5%), Fasciola spp. (11.1%), and Clonorchis sinensis (8.7%). Mono-infection by one species (11.1%) was lower than multiple infections (53.0%) (P<0.05). The seroprevalence in males (59.3%) was lower than in females (66.2%) but not statistically significant (P>0.05). Children (<15 years) revealed lower seroprevalence (34.0%) than adults (68.4%), and the age group 51-70 years revealed the highest seroprevalence (76.0%). Among the seropositive patients, eosinophilia (≥8.0%) was noted in 80.2%. The present results suggested active transmission of various tissue and luminal helminths among people in Hanoi, Vietnam.
4.Two Human Cases of Echinococcus ortleppi Infection in the Lung and Heart in Vietnam
Nguyen Van DE ; Pham Ngoc MINH ; Le Van DUYET ; Nguyen Ngoc BICH ; Trinh Nam SON ; Bong-Kwang JUNG ; Jong-Yil CHAI
The Korean Journal of Parasitology 2020;58(4):451-456
This is a report of 2 cases of human hydatidosis caused by Echinococcus ortleppi in Vietnam. The patients were a 12-year-old male (case 1) having a cyst of 10.0×9.0 cm size in the lung and a 50-year-old female with a 3.0×3.3 cm-sized cyst in the heart. Eosinophilia was 33.7% in the male and 45.8% in the female patient. C-reactive protein was increased to 16.5 mg/L in the male and 18.2 mg/L in the female. Both patients were positive for ELISA at OD=2.5 and 3.1, respectively. Echinococcus protoscolices were collected from the cysts by amniocentesis and surgery. The protoscolices were identified as E. ortleppi by morphology and analysis of mitochondrial NADH dehydrogenase 1 (nad1) gene sequence. Both patients were cured by surgical resection of the hydatid cyst combined with albendazole medication. The E. ortleppi infection in lung is the second report, and the other in the heart is the first in Vietnam.
5.Mesenchymal Stem Cell Transplantation for Ischemic Diseases:Mechanisms and Challenges
Thi-Tuong VAN NGUYEN ; Ngoc Bich VU ; Phuc Van PHAM
Tissue Engineering and Regenerative Medicine 2021;18(4):587-611
Ischemic diseases are conditions associated with the restriction or blockage of blood supply to specific tissues. These conditions can cause moderate to severe complications in patients, and can lead to permanent disabilities. Since they are blood vessel-related diseases, ischemic diseases are usually treated with endothelial cells or endothelial progenitor cells that can regenerate new blood vessels. However, in recent years, mesenchymal stem cells (MSCs) have shown potent bioeffects on angiogenesis, thus playing a role in blood regeneration. Indeed, MSCs can trigger angiogenesis at ischemic sites by several mechanisms related to their trans-differentiation potential. These mechanisms include inhibition of apoptosis, stimulation of angiogenesis via angiogenic growth factors, and regulation of immune responses, as well as regulation of scarring to suppress blood vessel regeneration when needed. However, preclinical and clinical trials of MSC transplantation in ischemic diseases have shown some limitations in terms of treatment efficacy. Such studies have emphasized the current challenges of MSC-based therapies. Treatment efficacy could be enhanced if the limitations were better understood and potentially resolved. This review will summarize some of the strategies by which MSCs have been utilized for ischemic disease treatment, and will highlight some challenges of those applications as well as suggesting some strategies to improve treatment efficacy.
6.Mesenchymal Stem Cell Transplantation for Ischemic Diseases:Mechanisms and Challenges
Thi-Tuong VAN NGUYEN ; Ngoc Bich VU ; Phuc Van PHAM
Tissue Engineering and Regenerative Medicine 2021;18(4):587-611
Ischemic diseases are conditions associated with the restriction or blockage of blood supply to specific tissues. These conditions can cause moderate to severe complications in patients, and can lead to permanent disabilities. Since they are blood vessel-related diseases, ischemic diseases are usually treated with endothelial cells or endothelial progenitor cells that can regenerate new blood vessels. However, in recent years, mesenchymal stem cells (MSCs) have shown potent bioeffects on angiogenesis, thus playing a role in blood regeneration. Indeed, MSCs can trigger angiogenesis at ischemic sites by several mechanisms related to their trans-differentiation potential. These mechanisms include inhibition of apoptosis, stimulation of angiogenesis via angiogenic growth factors, and regulation of immune responses, as well as regulation of scarring to suppress blood vessel regeneration when needed. However, preclinical and clinical trials of MSC transplantation in ischemic diseases have shown some limitations in terms of treatment efficacy. Such studies have emphasized the current challenges of MSC-based therapies. Treatment efficacy could be enhanced if the limitations were better understood and potentially resolved. This review will summarize some of the strategies by which MSCs have been utilized for ischemic disease treatment, and will highlight some challenges of those applications as well as suggesting some strategies to improve treatment efficacy.
7.The correlation between ambulatory blood pressure parameters and cardiovascular risk factors in older adults with high-risk hypertension
Van Nam TRAN ; Huy Truong HOANG ; Thi Bich Thuan LE
Hue Journal of Medicine and Pharmacy 2023;13(6):34-
Objective: To explore the correlation of 24-hour ambulatory blood pressure (BP) monitoring (ABPM) parameters and cardiovascular risk factors in older adults with high-risk hypertension. Material and method: A cross-sectional study was conducted on 96 older adults (≥ 60 years old) with treated high-risk hypertension. Socio-demographic and cardiovascular risk information were gathered. The patients were performed 24-hour ABPM. Results: The mean age was 70.88 ± 7.86 years, and 64.6% were women. The prevalence of cardiovascular risk factors was as follows: dyslipidemia: 80.2%, family history of hypertension: 54.2%, diabetes mellitus: 51%, smoking: 24%, prior stroke: 11.5%. Significant differences in 24-hour, awake, and sleep systolic BP were observed between men and women. There were significant correlations between 24-hour mean systolic BP with age (r = 0.229, p = 0.025), dyslipidemia (r = 0.223, p = 0.029), family history of hypertension (r = 0.214, p = 0.036), BMI (r = 0.212, p = 0.039), waist circumference (r = 0.226, p = 0.027) and creatinine level (r = 0.207, p = 0.043). There were significant correlations between 24-hour mean diastolic BP with BMI (r = 0.289, p = 0.004) and prior stroke (r = -0.224, p = 0.029). There were significant correlations between 24-hour mean BP with BMI (r = 0.268, p = 0.009), waist circumference (r = 0.220, p = 0.032) and prior stroke (r = -0.215, p = 0.036). Conclusion: There were significant correlations between ABPM parameters and cardiovascular risk factors in older adults with high-risk hypertension.
8.Probiotic potential of lactic acid bacteria isolated from Vietnamese sour-fermented fish product
Nguyen Pham Anh Thi ; Tran Huu Hau ; Nguyen Thi Nhu Huynh ; Huynh Van Liem ; Tran Kieu Dieu Thi ; Do Phuong Kieu ; Dang Huy Hoa ; Nguyen Thanh Nha ; Nguyen Pham Thien Trang ; Le Nguyen Khoi Nguyen ; Truong Thi Bich Van ; Do Tan Khang
Malaysian Journal of Microbiology 2022;18(2):222-226
Aims:
To isolate and characterize the lactic acid bacteria (LAB) strains from the “mam chua ca ro” (sour fermented fish) in the South of Vietnam and investigate their potential anti-bacterial properties.
Methodology and results:
Four LAB strains (MCR1, MCR2, MCR3 and MCR4) were isolated from the "mam chua ca ro" product and their anti-bacterial activity was determined using the spot assay and the paper disc diffusion method. The isolated LABs can inhibit Escherichia coli ATCC 25922, Staphyloccocus aureus ATCC 25923 and Vibrio parahaemolyticus BV016 and produce bacteriocin to control the growth of E. coli ATCC 25922 and S. aureus ATCC 25923, except V. parahaemolyticus. MCR2 was chosen to sequence 16S rRNA of Pediococcus acidilactic.
Conclusion, significance and impact of study
On the basis of their prominent anti-pathogenic bacteria activity, LAB strains isolated from Vietnamese sour-fermented fish products were verified as prospective probiotics.
Lactobacillales--isolation &
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purification
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Pediococcus acidilactici
9.New oligomeric neolignans from the leaves of Magnolia officinalis var. biloba.
Van-Tuan VU ; Xiao-Juan XU ; Kang CHEN ; Manh-Tuyen NGUYEN ; Bich-Ngoc NGUYEN ; Giang-Nam PHAM ; Ling-Yi KONG ; Jian-Guang LUO
Chinese Journal of Natural Medicines (English Ed.) 2021;19(7):491-499
Six new oligomeric neolignans including two trimeric neolignans (1 and 2) and four dimeric neolignans (3-6) were isolated from the leaves of Magnolia officinalis var. biloba. Their structures were determined based on HR-ESIMS and NMR data, as well as electronic circular dichroism (ECD) calculations. Compound 1 is formed from two obovatol moieties directly linked to an aromatic ring of the remaining obovatol moiety, which is an unprecedented type of linkage between monomers. All isolates were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 1 and 3 showed significantly inhibitory activities with IC
Animals
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Lignans/pharmacology*
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Magnolia/chemistry*
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Mice
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Molecular Structure
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Phytochemicals/pharmacology*
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Plant Extracts/pharmacology*
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Plant Leaves/chemistry*
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RAW 264.7 Cells