1.Avian influenza A(H7N9) and the closure of live bird markets
Manoj Murhekar ; Yuzo Arima ; Peter Horby ; Katelijn AH Vandemaele ; Sirenda Vong ; Feng Zijian ; Chin-Kei Lee ; Ailan Li
Western Pacific Surveillance and Response 2013;4(2):4-7
On 31 March 2013, the National Health and Family Planning Commission, China notified the World Health Organization of three cases of human infection with avian influenza A(H7N9) from Shanghai and Anhui.1 By 8 May, 131 cases, including 26 deaths, had been notified from 11 provinces/municipalities.1,2 The majority (81%) of reported cases were from Shanghai municipality and Zhejiang and Jiangsu provinces. Available data indicate that more than three quarters of cases (59/77, 76%) had recent exposure to animals. Among these, 58% (34/59) had direct contact with chickens and 64% (38/59) visited a live bird market (LBM).3 Provincial and national authorities in China have collected more than 80 000 samples from LBMs, poultry slaughter houses, poultry farms, wild bird habitats, pig slaughter houses and their environments. As of 7 May, 50 samples were positive for avian influenza A(H7N9): 39 samples from poultry from LBMs in Anhui, Jiangsu, Jiangxi, Guangdong, Shanghai and Zhejiang provinces/municipalities (26 chickens, three ducks, four pigeons, six unknown) and 11 environmental samples from LBMs in Shanghai, Henan and Shandong provinces.4 None of the samples from poultry farms or pigs were positive
2.The potential for a controlled human infection platform in Singapore.
Shobana BALASINGAM ; Peter HORBY ; Annelies WILDER-SMITH
Singapore medical journal 2014;55(9):456-461
For over 100 years, controlled human infection (CHI) studies have been performed to advance the understanding of the pathogenesis, treatment and prevention of infectious diseases. This methodology has seen a resurgence, as it offers an efficient model for selecting the most promising agents for further development from available candidates. CHI studies are utilised to bridge safety and immunogenicity testing and phase II/III efficacy studies. However, as this platform is not currently utilised in Asia, opportunities to study therapeutics and vaccines for infections that are important in Asia are missed. This review examines the regulatory differences for CHI studies between countries and summarises other regulatory differences in clinical trials as a whole. We found that the regulations that would apply to CHI studies in Singapore closely mirror those in the United Kingdom, and conclude that the regulatory and ethical guidelines in Singapore are compatible with the conduct of CHI studies.
Asia
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Clinical Trials as Topic
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economics
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standards
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Communicable Disease Control
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Communicable Diseases
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epidemiology
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Cost-Benefit Analysis
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Ethics, Medical
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Health Policy
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Humans
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Infectious Disease Medicine
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legislation & jurisprudence
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standards
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Quarantine
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Research Design
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standards
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Singapore
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United Kingdom
3.Clinical characteristics of human infection with a novel avian-origin influenza A(H10N8) virus.
Wei ZHANG ; Jianguo WAN ; Kejian QIAN ; Xiaoqing LIU ; Zuke XIAO ; Jian SUN ; Zhenguo ZENG ; Qi WANG ; Jinxiang ZHANG ; Guanghui JIANG ; Cheng NIE ; Rong JIANG ; Chengzhi DING ; Ran LI ; Peter HORBY ; Zhancheng GAO
Chinese Medical Journal 2014;127(18):3238-3242
BACKGROUNDNovel influenza A viruses of avian-origin may be the precursors of pandemic strains. This descriptive study aims to introduce a novel avian-origin influenza A (H10N8) virus which can infect humans and cause severe diseases.
METHODSCollecting clinical data of three cases of human infection with a novel reassortment avian influenza A (H10N8) virus in Nanchang, Jiangxi Province, China.
RESULTSThree cases of human infection with a new reassortment avian influenza A(H10N8) virus were described, of which two were fatal cases, and one was severe case. These cases presented with severe pneumonia that progressed to acute respiratory distress syndrome (ARDS) and intractable respiratory failure.
CONCLUSIONThis novel reassortment avian influenza A (H10N8) virus in China resulted in fatal human infections, and should be added to concerns in clinical practice.
Aged ; Antiviral Agents ; therapeutic use ; Female ; Fluoroquinolones ; therapeutic use ; Humans ; Imipenem ; therapeutic use ; Influenza A Virus, H10N8 Subtype ; drug effects ; pathogenicity ; Influenza, Human ; complications ; diagnosis ; drug therapy ; Male ; Middle Aged ; Oseltamivir ; therapeutic use