1.Patch testing with different allergen series: Retrospective study from Selayang Hospital,Malaysia
Malaysian Journal of Dermatology 2011;27(-):20-20
Background:
Majority of the hospitals in Malaysia have limited allergen series for patch testing. Since January 2011, Department of Dermatology in Selayang Hospital has extended its number of allergen series available for testing.
Objectives:
The aim of this study was to evaluate whether other series besides the European baseline series (EBS) deserve to be tested on suspected patient with contact dermatitis.
Methods:
Patch test results of patients visiting Dermatology clinic in Selayang Hospital from January 2001 to June 2011 were
reviewed retrospectively.
Results:
Out of 129 patients who were patch tested, 98 (76%) patients had positive patch test, 30 (23.3%) patients had negative patch test and 1 (0.7%) patient had ‘Angry back’ reaction. The most commonly positive allergens were Nickel sulfate 45 (34.9%), Cobalt chloride 21 (16.3%), Potassium dichromate 15 (11.6%) and Balsam Peru 15 (11.6%). None of the patient had positive patch test to Mercaptobenzothiazole, Sesquiterpene lactone mix, Fragrance mix II and Lyral in the (EBS). The
number of patient that will be missed if certain series are not tested were Textile Colours & Finish (TF) (n=4/7, 57.1%), Plastic & Glues (PG) (n=4/19, 21.1%), Hairdressing (n=1/5, 20%), Cosmetic (n=2/12, 16.7%), Rubber Additives (n=12/77, 15.6%), Medicament (n=1/9, 11.1%), Plant (n=0/5, 0%), Cutaneous Adverse Drug Reaction (n=0/3, 0%) and Leg Ulcer (n=0/1, 0%).
Conclusion:
The absence of positive patch test to Mercaptobenzothiazole, Sesquiterpene lactone mix, Fragrance mix II and Lyral does
not support inclusion in the EBS in our region. Additional series especially TF and PG are important series to be tested in suspected patient.
2.Erythroderma - A retrospective study with special emphasis on good prognosis
Peter Ch’ng WB ; Adam B ; Rohna R
Malaysian Journal of Dermatology 2011;26(-):1-5
Background Erythroderma is a serious condition in itself, quite apart from hazards associated with
the underlying disease, and is sometimes fatal. Prognostic studies are rare in the literature and to date
there are no published studies to identify the factors that can determine good prognosis.
Objectives The aim of the study is to determine the factors that can prognosticate the good outcome
of erythroderma.
Methodology Cross sectional study from patients diagnosed to have erythroderma between 2003
and 2007 were analyzed with regard to age, sex, race, underlying medical illness, aetiology, duration
of rash before diagnosis of erythroderma, response to topical therapy and prognosis.
Results Four variables (aetiology, gender, duration of rash before being diagnosed as erythroderma
and response to topical therapy) were associated with good prognosis. These variables were
statistically significant from univariate analysis. When these variables were included into the binary
logistic model, the study did not have enough evidence to proof that ‘aetiology’ and ‘gender’ can
determine good prognosis. Response to topical therapy and shorter duration of rash (equal and less
than 120 days) were significant with odds ratio (CI) of 4.11 (1.556, 10.885) and 4.608 (1.903,
11.155) respectively.
Conclusion Shorter duration of rash and response to topical therapy are important factors to
determine a good prognosis.