1.Clinical features of patients with malignant peritoneal mesothelioma initially presenting as a local inflammation.
Hui SONG ; Guoqi ZHENG ; Sichen WEI ; Yuxin YANG ; Xinliang WEI
Chinese Journal of Oncology 2014;36(4):312-313
Aged
;
Antineoplastic Combined Chemotherapy Protocols
;
therapeutic use
;
Calbindin 2
;
metabolism
;
Cholecystitis
;
pathology
;
Cisplatin
;
administration & dosage
;
Cystitis
;
pathology
;
Diagnosis, Differential
;
Female
;
Glutamates
;
administration & dosage
;
Guanine
;
administration & dosage
;
analogs & derivatives
;
Humans
;
Inflammation
;
pathology
;
Keratins
;
metabolism
;
Lung Neoplasms
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Male
;
Mesothelioma
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Middle Aged
;
Pemetrexed
;
Peritoneal Neoplasms
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Survival Rate
;
Vimentin
;
metabolism
2.Recurrent follicular dendritic cell sarcoma in abdomen: report of a case.
Jing LIU ; Rui ZHANG ; Zheng-long ZHU ; Peng CAO ; Xia LI ; Ping ZHOU ; Wei ZHANG
Chinese Journal of Pathology 2010;39(10):709-710
Abdominal Neoplasms
;
drug therapy
;
metabolism
;
pathology
;
secondary
;
surgery
;
Dendritic Cell Sarcoma, Follicular
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Dendritic Cell Sarcoma, Interdigitating
;
metabolism
;
pathology
;
Diagnosis, Differential
;
Female
;
Gastrointestinal Stromal Tumors
;
metabolism
;
pathology
;
Histiocytoma, Malignant Fibrous
;
metabolism
;
pathology
;
Humans
;
Middle Aged
;
Neoplasm Recurrence, Local
;
Omentum
;
Peritoneal Neoplasms
;
secondary
;
Receptor, Epidermal Growth Factor
;
metabolism
;
Receptors, Complement 3b
;
metabolism
;
Receptors, Complement 3d
;
metabolism
3.ATP-Based Chemotherapy Response Assay in Primary or Recurrent Ovarian and Peritoneal Cancer.
Maria LEE ; Sang Wun KIM ; Eun Ji NAM ; Hanbyoul CHO ; Jae Hoon KIM ; Young Tae KIM ; Sunghoon KIM
Yonsei Medical Journal 2014;55(6):1664-1671
PURPOSE: To investigate chemosensitivity with an adenosine triphosphate-based chemotherapy response assay in patients with epithelial ovarian or peritoneal cancer according to tumor histology, grade, and disease status. MATERIALS AND METHODS: One hundred specimens were collected during primary or secondary debulking from 67 patients with primary ovarian cancer, 24 patients with recurrent ovarian cancer, 5 patients with primary peritoneal cancer, and 4 patients with recurrent peritoneal cancer; samples were collected between August 2006 and June 2009. Tumor cells were isolated and cultured for 48 hours in media containing chemotherapy. The chemosensitivity index (CI) was calculated as 300 minus the sum of the cell death rate at 0.2x, 1x, and 5x drug concentrations, and the CI values were compared. RESULTS: CI values were obtained from 93 of 100 patients. The most active agents against primary disease were ifosfamide and paclitaxel. For primary serous adenocarcinoma, paclitaxel and irinotecan were the most active, followed by ifosfamide. For clear cell carcinoma, ifosfamide was the most active, followed by paclitaxel and irinotecan. Although not statistically significant, the CIs of cisplatin, carboplatin, paclitaxel, and docetaxel decreased as tumor grade increased. In 14 cases of recurrent disease, paclitaxel was the most active, followed by ifosfamide and cisplatin. CONCLUSION: Ifosfamide and paclitaxel were the most active drugs for primary and recurrent disease. Therefore, we recommend further clinical studies to confirm the efficacy of paclitaxel, ifosfamide, and cisplatin combination chemotherapy for recurrent and primary ovarian cancer.
Adenocarcinoma, Clear Cell/*drug therapy/metabolism/pathology
;
Adenosine Triphosphate/*metabolism
;
Adult
;
Aged
;
Antineoplastic Combined Chemotherapy Protocols/*therapeutic use
;
Camptothecin/administration & dosage/analogs & derivatives
;
Carboplatin/therapeutic use
;
Cisplatin/administration & dosage
;
Drug Resistance, Neoplasm
;
Drug Screening Assays, Antitumor/methods
;
Female
;
Humans
;
Ifosfamide/administration & dosage
;
Middle Aged
;
Neoplasm Recurrence, Local/*drug therapy
;
Neoplasms, Glandular and Epithelial/*drug therapy/metabolism/pathology
;
Ovarian Neoplasms/*drug therapy/metabolism/pathology
;
Paclitaxel/therapeutic use
;
Peritoneal Neoplasms/*drug therapy/metabolism/pathology
;
Predictive Value of Tests
;
Sensitivity and Specificity
;
Taxoids/administration & dosage
4.KIT mutation analysis in pathological diagnosis and target-therapy of gastrointestinal stromal tumors: an update.
Chinese Journal of Pathology 2007;36(7):440-443
Antineoplastic Agents
;
therapeutic use
;
Benzamides
;
Drug Resistance, Neoplasm
;
Exons
;
Gastrointestinal Stromal Tumors
;
drug therapy
;
metabolism
;
pathology
;
Humans
;
Imatinib Mesylate
;
Mutation
;
Neurofibromatosis 1
;
metabolism
;
pathology
;
Omentum
;
Peritoneal Neoplasms
;
metabolism
;
pathology
;
Piperazines
;
therapeutic use
;
Prognosis
;
Proto-Oncogene Proteins c-kit
;
genetics
;
metabolism
;
Pyrimidines
;
therapeutic use
5.Clinicopathological and molecular genetic characteristics of childhood diffuse large B cell lymphoma.
Hui HUANG ; Wen-ping YANG ; Hong-yan XU
Chinese Journal of Oncology 2012;34(3):209-211
Adolescent
;
Antigens, CD20
;
metabolism
;
Antineoplastic Combined Chemotherapy Protocols
;
therapeutic use
;
Burkitt Lymphoma
;
drug therapy
;
metabolism
;
pathology
;
surgery
;
Child
;
Child, Preschool
;
Cyclophosphamide
;
therapeutic use
;
DNA-Binding Proteins
;
metabolism
;
Doxorubicin
;
therapeutic use
;
Female
;
Follow-Up Studies
;
Genes, myc
;
Humans
;
Hyaluronan Receptors
;
metabolism
;
Ki-67 Antigen
;
metabolism
;
Lymphoma, Large B-Cell, Diffuse
;
drug therapy
;
genetics
;
metabolism
;
pathology
;
surgery
;
Male
;
Neoplasm Staging
;
Neprilysin
;
metabolism
;
Peritoneal Neoplasms
;
drug therapy
;
genetics
;
metabolism
;
pathology
;
surgery
;
Prednisone
;
therapeutic use
;
Proto-Oncogene Proteins c-bcl-2
;
metabolism
;
Proto-Oncogene Proteins c-bcl-6
;
Stomach Neoplasms
;
drug therapy
;
genetics
;
metabolism
;
pathology
;
surgery
;
Translocation, Genetic
;
Vincristine
;
therapeutic use
6.Suppressive Effect of 19-nor-1alpha-25-Dihydroxyvitamin D2 on Gastric Cancer Cells and Peritoneal Metastasis Model.
Mi Ra PARK ; Ji Hee LEE ; Myung Suk PARK ; Jun Eul HWANG ; Hyun Jeong SHIM ; Sang Hee CHO ; Ik Joo CHUNG ; Woo Kyun BAE
Journal of Korean Medical Science 2012;27(9):1037-1043
The active metabolite of vitamin D, 1,25-dihydroxyvitamin D3 (calcitriol), inhibits the growth of several types of human cancer cells in vitro, but its therapeutic use is limited because it causes hypercalcemia. Among its analogs, 19-nor-1,25-dihydroxyvitamin D2 (paricalcitol), has fewer calcemic effects and exhibits an activity equipotent to that of calcitriol. We assessed the antitumor and anti-inflammatory effects of paricalcitol in gastric cancer cells, and evaluated the potential role of vitamin D in the treatment of peritoneal metastatic gastric cancer. In this study, treatment with paricalcitol inhibited gastric cancer cell growth and induced cell cycle arrest. Paricalcitol also induced apoptosis and showed anti-inflammatory activity. Moreover, the growth of intraperitoneal metastases in vivo was reduced in mice treated with paricalcitol. 18F-FDG uptake was significantly lower in the paricalcitol group compared to control group (SUV; control group 13.2 +/- 5.3 vs paricalcitol group 4.5 +/- 3.0). Intraperitoneal tumor volume was significantly lower in paricalcitol treated mice (control group 353.2 +/- 22.9 mm3 vs paricalcitol group 252.0 +/- 8.4 mm3). These results suggest that the vitamin D analog, paricalcitol, has anticancer activity on gastric cancer cells by regulation of the cell cycle, apoptosis, and inflammation.
Animals
;
Antineoplastic Agents/chemistry/*pharmacology/therapeutic use
;
Apoptosis/drug effects
;
Cell Cycle Checkpoints/drug effects
;
Cell Cycle Proteins/metabolism
;
Cell Line, Tumor
;
Cell Proliferation/drug effects
;
Disease Models, Animal
;
Ergocalciferols/chemistry/*pharmacology/therapeutic use
;
Fluorodeoxyglucose F18/chemistry/diagnostic use
;
Humans
;
Mice
;
Mice, Inbred BALB C
;
Peritoneal Neoplasms/drug therapy/*secondary
;
Positron-Emission Tomography
;
Stomach Neoplasms/drug therapy/*pathology
;
Transplantation, Heterologous