1.Multivariable analysis of tooth loss in subjects with severe periodontitis over 4-year natural progression.
Jing WEN ; Xiang Ying OUYANG ; Xi Yan PEI ; Shan Yong QIU ; Jian Ru LIU ; Wen Yi LIU ; Cai Fang CAO
Journal of Peking University(Health Sciences) 2023;55(1):70-77
OBJECTIVE:
To evaluate the characteristics of severe periodontitis with various number of tooth loss during 4-year natural progression, and to analyze the factors related to higher rate of tooth loss.
METHODS:
A total of 217 patients aged 15 to 44 years with severe periodontitis were included, who participated in a 4-year natural progression research. Data obtained from questionnaire survey, clinical examination and radiographic measurement. Tooth loss during 4-year natural progression was evaluated. The baseline periodontal disease related and caries related factors were calculated, including number of teeth with bone loss > 50%, number of missing molars, number of teeth with widened periodontal ligament space (WPDL), number of teeth with periapical lesions and etc. Characteristics of populations with various number of tooth loss and the related factors that affected higher rate of tooth loss were analyzed.
RESULTS:
In 4 years of natural progression, 103 teeth were lost, and annual tooth loss per person was 0.12±0.38. Nine patients lost 3 or more teeth. Thirty-four patients lost 1 or 2 teeth, and 174 patients were absent of tooth loss. Molars were mostly frequent to lose, and canines presented a minimum loss. The number of teeth with WPDL, with periapical lesions, with intrabony defects, with probing depth (PD)≥7 mm, with PD≥5 mm, with clinical attachment loss≥5 mm, with bone loss > 50% and with bone loss > 65% were positively correlated to number of tooth loss. Results from orderly multivariate Logistic regression showd that the number of teeth with bone loss > 50% OR=1.550), baseline number of molars lost (OR=1.774), number of teeth with WPDL (1 to 2: OR=1.415; ≥3: OR=13.105), number of teeth with periapical lesions (1 to 2: OR=4.393; ≥3: OR=9.526) and number of teeth with caries/residual roots (OR=3.028) were significant risk factors related to higher likelihood of tooth loss and multiple tooth loss.
CONCLUSION
In 4 years of natural progression, the number of teeth with bone loss > 50%, baseline number of missing molars, number of teeth with WPDL, baseline number of teeth with periapical lesions and number of teeth with caries/residual roots were significantly related to higher risk of tooth loss and multiple tooth loss among Chinese young and middle-aged patients with severe periodontitis in rural areas.
Humans
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Tooth Loss/etiology*
;
Periodontitis/complications*
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Tooth
;
Periodontal Diseases
;
Molar
2.The influence of orthodontic treatment on dental pulp and periapical tissues.
Xiaowei ZHANG ; Jingping LIANG
Chinese Journal of Stomatology 2016;51(5):317-320
The pathogenesis of pulpal and periapical diseases is related with not only bacterial infection but also physicochemical irritations such as trauma and thermal changes. During orthodontic therapy, the application of orthodontic forces on teeth may produce a series of changes in periodontal ligament, alveolar bone and pulpo-dentinal complex. This article reviewed the influences of orthodontic therapy on dental pulp and periapical tissues.
Dental Pulp
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Dental Pulp Diseases
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etiology
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Dentin
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Humans
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Orthodontics
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Periapical Diseases
;
etiology
;
Periapical Tissue
;
Periodontal Ligament
3.Periodontal status in patients with oral submucous fibrosis.
Chunjiao XU ; Jing ZHAO ; Quan LI ; Fenlian LI ; Juan LI ; Lei ZHANG ; Feng GUO ; Qingping GAO ; Yingfang WU
Journal of Central South University(Medical Sciences) 2009;34(9):914-918
OBJECTIVE:
To investigate the periodontal status in patients with oral submucous fibrosis (OSF), and to provide reference for the treatment and prophylaxis in patients with OSF and betel chewers.
METHODS:
Fifty samples clinically and pathologically diagnosed as OSF patients were selected as the OSF group, another 50 age-matched healthy volunteers in the similar living condition were compared with the OSF patients and non-betel nut chewers were classified as the control group. The 5 periodontal clinical parameters were collected and recorded, including plaque index, periodontal probing depth, clinical attachment loss, gingival index, and tooth count of bleeding of probing.
RESULTS:
There was a significant difference in plaque index (PLI) between the OSF group (2.14+/-0.64) and the control group (1.7+/-0.89) (P<0.01). Periodontal probing depth (PD) was (1.98+/-0.70) mm in the control group, and (5.57+/-2.39) mm in the OSF group, with significant difference in PD (P<0.01). There was no significant difference in clinical attachment loss, gingival index, and tooth count of bleeding on probing between the 2 groups (P>0.05).
CONCLUSION
OSF patients tend to accumulate plaque, and have deep periodontal pocket, periodontal inflammation or severe periodontal damage.
Adult
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Areca
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adverse effects
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Case-Control Studies
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Female
;
Humans
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Male
;
Oral Submucous Fibrosis
;
complications
;
Periodontal Diseases
;
etiology
;
Periodontal Pocket
;
etiology
;
Young Adult
4.Periodontal Status of Chronic Renal Failure Patients Receiving Hemodialysis.
Ismail MARAKOGLU ; Ulvi Kahraman GURSOY ; Serhat DEMIRER ; Hafize SEZER
Yonsei Medical Journal 2003;44(4):648-652
Host factors such as systemic diseases, genetic polymorphism or drug usage play a major role in the pathogenesis of periodontal disease by modifying the host response to periodontal infection or altering the susceptibility to infection by periodontal organisms. This study was designed to evaluate the clinical response of patients receiving hemodialysis to existing microbial dental plaque. Gingival Index (GI) and Plaque Index (PI) scores and probing depths (PD) were recorded for the entire dentition on 36 chronic renal failure patients receiving hemodialysis (H) and 36 systemically healthy individuals (C), matched with the patient group, based on age and extent of plaque accumulation. No statistically significant difference was observed in the clinical parameters between the two groups (PI: t=1.69 p= 0.096; GI: t=1.057 p=0.294; PD: t=0.01 p=0.99). In the present study, H patients revealed a similar response to existing bacterial plaque and their periodontal status was comparable to that of the control group. Although patients receiving hemodialysis have been suggested to present a certain degree of immunosuppression, based on the findings of the present study chronic renal failure does not seem to be an additional risk factor for more severe periodontal destruction.
Adult
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Aged
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Female
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Human
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Kidney Failure, Chronic/*complications/*therapy
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Middle Aged
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Periodontal Diseases/*etiology
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*Renal Dialysis
6.The mechanism and influencing factors of halitosis.
Chinese Journal of Stomatology 2013;48(9):566-569
7.The cytokine network involved in the host immune response to periodontitis.
Weiyi PAN ; Qingxuan WANG ; Qianming CHEN
International Journal of Oral Science 2019;11(3):30-30
Periodontitis is an inflammatory disease involving the destruction of both soft and hard tissue in the periodontal region. Although dysbiosis of the local microbial community initiates local inflammation, over-activation of the host immune response directly activates osteoclastic activity and alveolar bone loss. Many studies have reported on the cytokine network involved in periodontitis and its crucial and pleiotropic effect on the recruitment of specific immunocytes, control of pathobionts and induction or suppression of osteoclastic activity. Nonetheless, particularities in the stimulation of pathogens in the oral cavity that lead to the specific and complex periodontal cytokine network are far from clarified. Thus, in this review, we begin with an up-to-date aetiological hypothesis of periodontal disease and summarize the roles of cytokines in the host immune response. In addition, we also summarize the latest cytokine-related therapeutic measures for periodontal disease.
Alveolar Bone Loss
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etiology
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Cytokines
;
metabolism
;
physiology
;
Humans
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Inflammation
;
Periodontal Diseases
;
Periodontitis
;
immunology
;
microbiology
;
Tumor Necrosis Factor-alpha
;
physiology
8.Diabetes as a risk factor for periodontal disease: current status and future considerations.
Wah Ching TAN ; Fidelia B K TAY ; Lum Peng LIM
Annals of the Academy of Medicine, Singapore 2006;35(8):571-581
INTRODUCTIONOver the past decade, there has been an emerging interest in the interrelationship between systemic conditions and oral health. Diabetes is perhaps one of the best documented conditions that have been closely linked with periodontal disease. This paper reviews the role of diabetes as a risk factor in periodontal disease. The treatment implications in the management of periodontal disease as an integral component of diabetes care is also discussed in light of the current understanding of the pathogenesis of these 2 chronic conditions.
MATERIALS AND METHODSEpidemiological, clinical and laboratory studies examining the relationship between diabetes and periodontal diseases were selected from both medical and dental journals.
RESULTSThe severity of periodontal destruction has been shown to be related to the direct and indirect effects of glycaemic control, with other factors also being implicated. Although some studies have pointed towards a bi-directional relationship between glycaemic control and periodontal health, it is still not clear if improvement in periodontal health could lead to improved metabolic control.
CONCLUSIONDiabetes and periodontal disease are closely related in many ways, though the effect of periodontal disease on diabetes control remain to be determined, with larger intervention studies. In light of the increasing evidence of the relationship between diabetes and periodontal disease, management of oral health should form an integral part of diabetes management.
Anti-Infective Agents ; pharmacology ; Blood Glucose ; drug effects ; Diabetes Complications ; Diabetes Mellitus ; blood ; physiopathology ; Humans ; Periodontal Diseases ; drug therapy ; etiology ; immunology ; prevention & control ; Risk Factors
9.Tooth Loss May Predict Poor Cognitive Function in Community-Dwelling Adults without Dementia or Stroke: The PRESENT Project.
Hyunyoung PARK ; Seung Han SUK ; Jin Sung CHEONG ; Hak Seung LEE ; Hyuk CHANG ; Seung Yeon DO ; Ji Sook KANG
Journal of Korean Medical Science 2013;28(10):1518-1521
Periodontal disease is a potential predictor of stroke and cognitive impairment. However, this association is unclear in adults aged 50 yr and above without a history of stroke or dementia. We evaluated the association between the number of teeth lost, indicating periodontal disease, and cognitive impairment in community-dwelling adults without any history of dementia or stroke. Dental examinations were performed on 438 adults older than 50 yr (315 females, mean age 63+/-7.8 yr; 123 males, mean age 61.5+/-8.5 yr) between January 2009 and December 2010. In the unadjusted analysis, odds ratios (OR) of cognitive impairment based on MMSE score were 2.46 (95% CI, 1.38-4.39) and 2.7 (95% CI, 1.57-4.64) for subjects who had lost 6-10 teeth and those who had lost more than 10 teeth, respectively, when compared with subjects who had lost 0-5 teeth. After adjusting for age, education level, hypertension, diabetes, hyperlipidemia, and smoking, the relationship remained significant (OR, 2.0; 95% CI, 1.08-3.69, P=0.027 for those with 6-10 teeth lost; OR, 2.26; 95% CI, 1.27-4.02, P=0.006 for those with more than 10 teeth lost). The number of teeth lost is correlated with cognitive impairment among community-dwelling adults aged 50 and above without any medical history of stroke or dementia.
Aged
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Aged, 80 and over
;
Cognition Disorders/*diagnosis/etiology
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Cohort Studies
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Dementia/pathology
;
Female
;
Humans
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Male
;
Middle Aged
;
Odds Ratio
;
Periodontal Diseases/complications
;
Residence Characteristics
;
Stroke/pathology
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*Tooth Loss
10.A Case of Liver Abscess Caused by Fusobacterium nucleatum in a Patient with Recurrent Periodontal Diseases.
Yong Hwan KIM ; Hee Jung YOON ; Chan Woong PARK ; Jung Ho KIM ; Min Kyung LEE ; Ki Bang KIM ; Dong Jib NA ; Ji Myung KIM
The Korean Journal of Gastroenterology 2011;57(1):42-46
Fusobacteria are anaerobic gram-negative, non-spore forming bacilli found in normal flora of the oral cavity, urogenital tract, and gastrointestinal tract. Fusobacterium nucleatum has been seldom reported as a cause of liver abscess, particularly in immunocompetent hosts. A 55-year-old man with frequent periodontal disease visited our hospital with intermittent fever and headache for 2 months. Abdominal CT scan revealed an 8.2x6 cm mass in the right hepatic lobe with central low density. Abscess culture revealed F. nucleatum as the causative organism. Percutaneous abscess drainage and intravenous administration of antibiotics for 4 weeks improved symptoms and decreased the abscess size. We report a rare case of liver abscess due to F. nucleatum in an immunocompetent man with periodontal disease.
Ampicillin/therapeutic use
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Anti-Bacterial Agents/therapeutic use
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Fusobacterium Infections/complications/*diagnosis/drug therapy
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Fusobacterium nucleatum/*isolation & purification
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Humans
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Injections, Intravenous
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Liver Abscess/*diagnosis/etiology/microbiology
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Male
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Middle Aged
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Periodontal Diseases/*diagnosis
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Sulbactam/therapeutic use