1.Functional Magnetic Resonance Imaging Findings in Meares-Irlen Syndrome: A Pilot Sudy.
Ji Hyun KIM ; Hye Jin SEO ; Suk Gyu HA ; Seung Hyun KIM
Korean Journal of Ophthalmology 2015;29(2):121-125
PURPOSE: To investigate patterns of functional magnetic resonance imaging (fMRI) activation during sentence reading before and after wearing color-tinted lenses. METHODS: A total of 15 Meares-Irlen syndrome patients with a mean age of 23.4 years (range, 13 to 42 years) with no history of neurological or psychiatric disorders were scanned using a 3T MR scanner (Siemens, Tim-Trio, Germany). Each patient underwent two sessions of fMRI imaging (before and after MISViS color-tinted lens application). The fMRI paradigm included a block design of 20 seconds of rest (cross), 20 seconds of activation (sentence reading), and ten blocks (a total of 200 echo-planar image volumes) repeated for each session. Data preprocessing and analyses were performed using the SPM8 software package. RESULTS: The reading speed of patients improved more than 20% while wearing the selected lenses. When compared to the before-lens session, the after-lens session identified significant regions of activation in the left middle and superior temporal gyri (paired t-test; maximal z score, 5.38; Montreal Neurological Institute coordinate, -60 / -39 / 0; threshold at p < 0.05; corrected for multiple comparisons using family-wise error). No region of activation at the same threshold was found in the before-lens session as compared to the after-lens session. CONCLUSIONS: In the current study, we confirmed activation in the left middle and superior temporal gyri during sentence reading after wearing color-tinted lenses. These results could explain the effectiveness of color-tinted lenses in patients with Meares-Irlen syndrome.
Adolescent
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Adult
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Brain/*pathology/physiopathology
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Color Perception/*physiology
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Dyslexia/*diagnosis/physiopathology
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*Eyeglasses
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Female
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Humans
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Magnetic Resonance Imaging/*methods
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Male
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Perceptual Disorders/*diagnosis/physiopathology
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Pilot Projects
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Reading
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Syndrome
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Vision Disorders/*diagnosis/physiopathology
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Young Adult