1.A Case of Possible Neurosarcoidosis with Dementic Features.
Heeyoung KANG ; Oh Young KWON ; Imsuk SUNG ; Ki Jong PARK ; Nack Cheon CHOI ; Byeong Hoon LIM
Journal of the Korean Neurological Association 2003;21(3):325-327
No abstract available.
Meningitis
;
Peptidyl-Dipeptidase A
2.In Silico profiling of the Angiotensin converting enzyme binding affinities, toxicity and Pharmacokinetics of compounds from the nuts of Areca Catechu, Linn. and its bioisosteres
Kenneth C. Ezeuba ; Joanna V. Toralba ; Junie B. Billones
Philippine Journal of Health Research and Development 2023;27(4):78-93
Background:
Hypertension is a worldwide epidemic that has been recognized as the most leading global risk for mortality, with its prevalence associated with increased blood pressure, concomitant risks of cardiovascular and kidney diseases, and major commonality in individuals advanced in age. With the current treatment options for hypertension management, there is still a need to develop therapies that directly target receptors that aid in hypertension treatment.
Methodology:
The study focused on the in-silico profiling of the reported compounds from Areca catechu L. (fam. Arecaceae) towards the n-domain and c-domain angiotensin converting enzyme (ACE) receptor models. Bioisosteric replacement was used to create bioisosteres investigated for similar binding affinity.
Results:
Some A. catechu compounds exhibited favorable binding energies towards the n- and c-domain receptor models of ACE, binding in the same ACE ligand binding site as lisinopril, benazepril, and sampatrilat via similar interactions and amino acid residues. The majority of A. catechu compounds with favorable ACE binding energies belong to the phytochemical classes of flavonoids, polyphenols and phenolics, glycosides, and steroids. After in silico toxicity and pharmacokinetic profiling, the bioisosteres Leuco-DM02-39, Leuco-DM02-66, Leuco-DM05-60, Querc-DM09-63, and Querc-DM14-31 with binding energies higher than their parent compounds and comparable to lisinopril, benazepril, and sampatrilat were deemed the best.
Conclusion
A. catechu compounds have the potential to target ACE n-domain and c-domain receptor models. Three leucocyanidin and two quercetin bioisosteres exhibited favorable binding to the n-domain and c-domain ACE receptor models and could be further optimized to derive a promising antihypertensive agent through ACE inhibition.
Peptidyl-Dipeptidase A
;
Areca
;
Hypertension
3.The effect of angiotensin converting enzyme inhibitor(enarlapril) on the capsicin-induced cough reflex.
Dong Soon KIM ; Seong Woon KWON ; Yong Bok KIM ; Chang Young LIM ; Suck Koo CHOI ; Won Sang YOO
Korean Journal of Medicine 1993;45(5):615-621
No abstract available.
Angiotensins*
;
Cough*
;
Peptidyl-Dipeptidase A*
;
Reflex*
4.A Case of Hyponatremia Due to Angiotensin Converting Enzyme Inhibitor.
Hye Young SUNG ; Hyun Jung JUNG ; Jeong Seon BAEG ; Hyun Young WOO ; Kyu Re JOO ; Kyung Mi KANG ; Sang Hun LEE ; Hye Suk SON ; Suk Joon SHIN ; Ho Chul SONG ; Eui Jin CHOI ; Kwang Soo LEE ; Joong Seok KIM
Journal of the Korean Geriatrics Society 2006;10(4):322-325
We describe a patient with hyponatremia induced by the use of angiotensin-converting enzyme (ACE) inhibitor; imidapril HCl. Although the mechanism of severe hyponatremia due to ACE inhibitor is not clear, it is conceivable that ACE inhibitor therapy may complicate the syndrome of inappropriate secretion of antidiuretic hormone and induce hyponatremia. In addition, the possibility should be considered that hyponatremia in our patient is a presumptive interaction between oxcarbazepine and imidapril HCl.
Angiotensins*
;
Humans
;
Hyponatremia*
;
Peptidyl-Dipeptidase A*
5.Relationship between angiotensin converting enzyme gene polymorphism and progression to renal failure in non-insulin dependent diabetes mellitus.
Korean Journal of Medicine 1999;57(2):242-243
No abstract available.
Angiotensins*
;
Diabetes Mellitus*
;
Peptidyl-Dipeptidase A*
;
Renal Insufficiency*
6.Angiotensin Converting Enzyme Inhibitors for the.
Journal of the Korean Pediatric Cardiology Society 2001;5(2):115-127
No Abstract available.
Angiotensin-Converting Enzyme Inhibitors*
;
Angiotensins*
;
Peptidyl-Dipeptidase A*
9.The changes of serum angiotensin converting enzyme activity in lung cancer patients.
Ki Ho JEONG ; Hyung Seok CHOI ; Chul Gyu YOO ; Kye Young LEE ; Young Whan KIM ; Sung Koo HAN ; Young Soo SHIM ; Keun Youl KIM ; Yong Chol HAN
Tuberculosis and Respiratory Diseases 1992;39(4):310-317
No abstract available.
Angiotensins*
;
Humans
;
Lung Neoplasms*
;
Lung*
;
Peptidyl-Dipeptidase A*
10.Growth Characteristics and Physiological Functionality of Yeasts in Pear Marc Extracts.
In Taek JANG ; Min Gu KANG ; Kwang Chul NA ; Jong Soo LEE
Mycobiology 2011;39(3):170-173
Kluyveromyces fragilis KCTC 7260 and Saccharomyces cerevisiae KCTC 7904, which both grew well in pear marc extract, were selected and their growth profiles and physiological functionalities were determined. Both of the selected yeasts established maximal growth by 20 hr of cultivation at 30degrees C in pear marc extract. The cell-free extracts showed high antihypertensive angiotensin I-converting enzyme inhibitory activity of 68.9% and 52.1%, respectively. The extracts also displayed 9.2 U/mL and 12.0 U/mL of protease activity, respectively.
Kluyveromyces
;
Peptidyl-Dipeptidase A
;
Pyrus
;
Saccharomyces cerevisiae
;
Yeasts