1.Polypeptides Inhibiting Angiogenesis.
Na Sun HAH ; Seo Jin LEE ; Seung Taek LEE
Journal of Korean Society of Endocrinology 2001;16(3):377-391
No abstract available.
Peptides*
2.Interaction Among Hormones or Peptides May Be Involved in Gastric Motor Physiology.
Journal of Neurogastroenterology and Motility 2012;18(4):353-354
No abstract available.
Peptides
3.Overview of Roles for Non-cardiac Natriuretic Peptides: Roles in Neural, Endocrine and Immune Systmes.
Kyung Woo CHO ; Suhn Hee KIM ; Sung Joo KIM
Journal of Korean Society of Endocrinology 2000;15(6):760-778
No Abstract Available.
Natriuretic Peptides*
4.Partial purification and characterization of antimicrobial peptide(s) from Mimosa pudica (Mimosaceae)
Johnalyn C. Go ; Marilou G. Nicolas ; Gracia Fe B. Yu
Philippine Journal of Health Research and Development 2021;25(4):14-22
Plants have been a major source of natural products for sustaining human health. The use of the different parts of the plant as infusions, decoctions, extracts, and powders are being employed in the treatment of different diseases in humans, plants, and animals. One property of great significance in terms of therapeutic treatments, especially with the emergence of multi-drug resistant microbes, is the antimicrobial activity. A new promising source of antimicrobials that demonstrate novel mechanisms of therapeutic strategies is low molecular weight peptides. In this study, the antimicrobial activities of Mimosa pudica crude and partially purified peptide extracts against Gram-negative Enterobacter cloacae ATCC 23355 and Enterobacter aerogenes ATCC 13048, and Gram-positive Staphylococcus epidermidis ATCC 12228 using resazurin colorimetric assay and tricine SDS-PAGE bioautography were reported. M. pudica crude and partially purified extracts exhibited antimicrobial activity against all the bacteria tested. Specifically, the peptide that was partially purified from M. pudica with a molecular weight of 5.14 kDa inhibited the growth of Enterobacter cloacae.
Antimicrobial Peptides
5.Growth Factors during Perinatal Life.
Journal of Korean Society of Pediatric Endocrinology 2004;9(2):113-121
No abstract available.
Intercellular Signaling Peptides and Proteins*
6.Expression of Antimicrobial Peptides and Proteins in Epidermis Equivalents Exposed to Salt Water and Narrowband Ultraviolet B Radiation.
Thilo GAMBICHLER ; Sarah TERRAS ; Marina SKRYGAN
Annals of Dermatology 2014;26(5):666-668
No abstract available.
Epidermis*
;
Peptides*
;
Water*
7.Changes of Detrusor Contractility and Growth Factors in Streptozotocin-induced.
Joon Chul KIM ; Seong Il SEO ; Yong Hyun PARK ; Tae Kon HWANG
Korean Journal of Urology 2000;41(5):615-621
No abstract available.
Intercellular Signaling Peptides and Proteins*
8.Development of RGD peptides grafted onto chitosan surfaces; Osteoblast interactions.
Chang Kyun LEE ; Jeong Hyo HWANG ; Yong Moo LEE ; Young KU ; In Chul RHYU ; Seung Jin LEE ; Soo Boo HAN ; Sang Mook CHOI ; Chong Pyoung CHUNG
The Journal of the Korean Academy of Periodontology 2003;33(1):27-35
No abstract available.
Chitosan*
;
Osteoblasts*
;
Peptides*
;
Transplants*
10.Assessment of lymphocytic function in vitro stimulated by specific tumor polypeptide combined with dendritic cells.
Duo YANG ; Xin Na ZHOU ; Shuo WANG ; Xiao Li WANG ; Yan Hua YUAN ; Hua Bing YANG ; Hui Zhen GENG ; Bing PENG ; Zi Bo LI ; Bin LI ; Jun REN
Journal of Peking University(Health Sciences) 2021;53(6):1094-1098
OBJECTIVE:
To assess the activation function of specific tumor polypeptide for dendritic cell vaccine on lymphocytes proliferation, production of cytokines and killing activity in vitro by using dendritic cells as antigen presenting vector.
METHODS:
Peripheral blood dendritic cells (DC) and cytokine-induced killer (CIK) were isolated and cultured by adherent culture method; CCK-8 method was used to assess the proliferation function of lymphocytes and the killing function of lymphocytes to tumor cells; enzyme-linked immunospot assay method was used to evaluate the secretion function of cytokines. The experiment was divided into tumor polypeptide group (peptide with DC-CIK), DC-CIK group and CIK group.
RESULTS:
With presence of interleukin-2 (IL-2) in the culture system, the lymphocyte proliferation of the three groups was obvious. The absorbance at 450 nm of tumor polypeptide group was significantly higher than that of CIK group at the time points day 4 and day 6 (day 4: Z=-3.79, P < 0.001; day 6: Z =-2.95, P < 0.01). The absorbance at 450 nm of group tumor polypeptide was significantly higher than that of DC-CIK group on day 4 (Z=-2.02, P < 0.05). Without IL-2 in the culture system, lymphocytes proliferated slowly in all the three groups, and there was no significant difference in 450 nm absorbance at each time point. The levels of IL-4 (Z=-2.61, P < 0.01), granulocyte-macrophage colony-stimulation factor (GM-CSF, Z=-3.85, P < 0.001), interferon- γ (IFN- γ, Z=-3.56, P < 0.001) and tumor necrosis factor-α (TNF-ɑ, Z=-3.40, P < 0.001) of tumor polypeptide group were higher than those of CIK group. There was no significant difference in the production of cytokines except IL-4 (Z=-2.15, P < 0.05) when tumor polypeptide group was compared with DC-CIK group. The production of IFN-γ (Z=-2.44, P < 0.05), TNF-ɑ (Z=-2.26, P < 0.05) and GM-CSF (Z=-3.73, P < 0.001) in DC-CIK group were higher than those of CIK group. Although there was no significant difference in killing activity between tumor polypeptide group, DC-CIK group and CIK group at hour 18 and hour 24, and the killing activity of tumor polypeptide group was higher than that of the other two groups.
CONCLUSION
Tumor peptide combined with dendritic cells can improve the proliferation activity of CIK cells in vitro, and increase the secretion of several cytokines.
Dendritic Cells
;
Peptides