1.Clinical Research Progress on Effects of Different Anesthesia Management on Stress Response
Chinese Journal of Minimally Invasive Surgery 2016;16(9):836-840
[Summary] Stress response is an organism ’ s mechanism of defense against various stimulations , involving nervous , endocrine , cardiovascular and immune systems .This review summarized the clinical research progress on effects of different anesthesia management on stress response and future trends of investigation .
2.Advances in Research on anoikis resistance of hepatocellular carcinoma
Xuemei LI ; Jike HU ; Baohong GU ; Fan ZHANG ; Dengfeng WANG ; Pengxian TAO ; Yajing CHEN ; Hao CHEN
Chinese Journal of Hepatobiliary Surgery 2019;25(5):390-393
The anoikis resistance confers the ability of cancer cells to survive and metastasize in the blood circulation without adhesion,but its effect and mechanism in intrahepatic and distant metastasis of hepatocellular carcinoma has not been fully elucidated.Recent studies have shown that certain factors or drugs may inhibit anoikis of hepatoma cells through some signaling pathways.These signaling pathways are not completely separated,they are interconnected to promote metastasis of hepatocellular carcinoma.Liver is the metabolic center of many substances,and many related factors can promote metastasis of hepatocellular carcinoma through inhibiting anoikis.In this review,we summarized the signaling pathways of anoikis resistance of hepatocellular carcinoma.
3.Advances in liver transplantation for patients with primary sclerosing cholangitis
Zhen MA ; Pengxian TAO ; Baohong GU ; Xuemei LI ; Dengfeng WANG ; Yajing CHEN ; Hao CHEN
Chinese Journal of Hepatobiliary Surgery 2018;24(4):279-282
Primary sclerosing cholangitis (PSC) is a common autoimmune liver disease,and the diversity of its treatment methods has been hotly discussed by scholars in various countries.As the best treatment,end-stage liver transplantation (LT),due to the related diseases,such as postoperative complications greatly limits its wide application in clinical practice.Early assessment and intervention can reduce the risk of concomitant disease and reduce the occurrence of postoperative complications.In this paper,the status of LT indications,timing and related disease management,postoperative complications and other aspects of PSC patients were reviewed.