To investigate a new teaching model so as to improve the teaching and learning efficiency of pharmaceutical analysis, a total of 61 undergraduates who majored in chemistry (pharmacy) were chosen as the trainees. The teaching reform based on Aalborg PBL model was conducted from such three aspects as teaching contents, teaching manners and assessment methods. Under the new teaching model, students' learning interest could be improved significantly, and their knowledge understanding, mastery and application were enhanced. Besides, the students' abilities of team work and communication were also cultivated.