Objective:To study histocompatibility of self-made stents made of NiTi alloy in rabbits.Methods: To place 30 stents made of NiTi alloy into 30 rabbits trachea through mouth under general anethesia,to observe local tissue reaction from 1 week to 6 months and to try to find pathological changes of main organs of rabbits in the 6 th month. Results:During observation,apart from dyspnea in two rabbits,one died at 3 day and the other died at 6 week after implantation. Autopsy showed the implanta.tion sites were occluded by granulation tissue. All other rabbits were normal and implantation sites were patent. In the first three weeks we could observe acute inflammation at the implantation sites while after 5 weeks we could observe chronic inflammation there. We observed that the structure of epithelial cells tended to be normal by telemicroscope. There are no pathological changes in liver, spleen, kidney, lung, heart and brain tissue. Conclusion:Self-expanding stents possess good histocompatibility and have no toxic reaction to whole body and fit to implantation into human body.