Our experiments have shown that bee venom possesses effects of significantly increasing the fluidity of erythrocyte membrane,markedly decreasing the whole blood and plasma viscosities,accelerating erythrocyte microelectrophoresis speed and reducing erythrocyte rigidity index in rabbit. The results showed that bee venom can markedly change some of the parameters of hemorrheology,and possess certain effects in promoting blood circulation to remove blood stasis.

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Objective To explore the conventional MRI,diffusion-weighted imaging (DWI)characteristics and the pathological basis of angiomatous meningioma.Methods The conventional MRI,DWI and pathological manifestations of 7 cases with angioma-tous meningioma confirmed by surgery and pathology were analyzed retrospectively.The apparent diffusion coefficient (ADC)value of the tumors and contralateral normal brain parenchyma were measured and compared with each other.Results Among the 7 ca-ses,5 cases were in the convexity of brain (4 cases in the frontal part and 1 case in the parietal part),and 2 cases in the parasella. 6 cases showed hypointense on T1 WI and hyperintense on T2 WI,and 1 case showed isointense on both T1 WI and T2 WI.The necro-sis within the tumor was seen in 2 cases.The flowing void phenomenon was seen in 6 cases.The significant peritumoral edema was seen in 5 cases on FLAIR.Significant enhancement on contrast-enhanced T1 WI was seen in all the cases.The average ADC value of the tumors (1.35×10 -3 mm2/s)was significently higher than that of the contralateral normal parenchyma (0.92 × 10 -3 mm2/s) (t=7.21,P <0.01).Mature vessel component was seen on pathological section in all the cases.For immunohistochemically analy-sis,the expression of vimentin (Vim)was positive in 6 cases and scattered positive in 1 case.The expression of epithelial membrane antigen (EMA)was positive in all the cases.Conclusion The MRI features of angiomatous meningioma are closely correlated with rich blood vessels.The ADC value of the tumor is higher than that of the contralateral parenchyma,which is helpful for the diagno-sis.

BACKGROUND:Spinal canal decompression and fusion combined with pedicle screw fixation has become the main method for the treatment of thoracolumbar fracture and dislocation. OBJECTIVE:To restore the vertebral height of the patients with thoracolumbar fracture and dislocation who underwent subtotal resection and decompression through titanium cage packed with autologous cancel ous bone and pedicle screw fixation. METHODS:Thirty-one patients with thoracolumbar fracture and dislocation treated in the Shanghai 6th People’ s Hospital of Shanghai Jiao Tong University from February 2007 to September 2011 were selected. Al the patients received subtotal resection, spinal canal decompression and titanium cage packed with autologous cancel ous bone and pedicle screw fixation. Imaging examination was performed before and after treatment to observe the recovery of vertebral sequence, vertebral height and Cobb angle, as wel as the recovery of nerve function. RESUTLS AND CONCLUSION:The patients were fol owed-up for 12 months, and al the patients healed wel after treated with titanium cage packed with autologous cancel ous bone and pedicle screw fixation, and there was no loosening, shedding or breakage after pedicle screw fixation. During reexamination, the grafts fusion, good deformity correction, basic recovery of vertebral height and good recovery of Cobb angle were observed. Seven cases had neurological function recovery, and among them, six cases raised for one degree, one case raised for two degrees, and another 22 cases without recovery. Case analysis and relative researches showed that subtotal resection and decompression and titanium cage packed with autologous cancel ous bone and pedicle screw fixation can reduce the loss of correction of the patients with thoracolumbar fracture and dislocation, restore the vertebral height, and enhance the stability of the vertebral body.

Objective To investigate the clinicopathologic and immunohistochemical features of gastric stromal tumors.Methods A total of 105 cases with gastric stromal tumors were included in the study.The expression of cluster of differentiation 117 (CD117),cluster of differ entiation 34 (CD34),smooth muscle actin (SMA),S-100 protein and Ki-67 in gastric stromal tumors specimens was detected by immunohistochemistry.The clinico-pathologic features of gastric stromal tumors were also analyzed.Results Of 105 gastric stromal tumors specimens,90 were positive for CD117 [85.7 ％ (90/105)],98 positive for CD34 [93.3 ％ (98/105)],21 positive for SMA [20.4 ％ (21/105)],60 positive for Ki-67 [56.1％ (60/105)],13 positive for S-100 [12.4 ％ (13/105)].Conclusion Combined detection of CD117 and CD34 can improve the diagnostic accuracy of gastric stromal tumors.The expression of Ki-67 can be used as a prognostic parameter for gastric stromal tumors as it is correlated with tumor size,risk and mitotic.

Objective To observe the mechanism of the change in runx3 in gastric carcinoma its difference and with p53 mutation.Methods A total of 30 cases of gastric carcinoma were taken from clinical operation.PCR-SSCP method was used to detect mutations in exons 2,3,4 of runx3 gene in the gastric carcinoma.The methylation status of runx3 gene was examined by methylation-specific polymerase chain reaction(MS-PCR),PCR-SSCP method was used to detect mutations in exons 5,6,7,8 of p53 gene in the gastric carcinoma.Results Two cases with mutation were found,methylation of runx3 promoter region was confirmed in 87%(26/30) specimens of gastric carcinoma,53.3%(16/30)cases were confirmed with mutation in the p53 gene.The rate of methylation of runx3 was higher than the rate of mutation of p53(P

Objective To determine the relationship between preoperative plasma D-dimer level and the lymphnode metastasis characteristics in colorectal cancer patients.Methods A total of 106 patients with colorectal cancer were studied in order to evaluate this relationship.Their preoperative plasma D-dimer levels were measured.Results were correlated with the clinicopathological findings.Results Significantly different plasma D-dimer levels were found with respect to histologic N(P ＜ 0.001).The number of lymph node metastases was found to have the strongest association with D-dimer level among the significant clinicopathologic factors (Spearman rank correlation,P ＜0.001).The most useful cutoff of the plasma D-dimer levels for diagnosis of lymph node metastasis was determined to be 0.4 μg/mL.Conclusion Plasma D-dimer levels can help assess lymph node metastasis in patients with eophageal cancer and should be measured preoperatively.

OBJECTIVE:To evaluate the clinical efficacy of amlodipine in treatment of vasospastic angina systematically.METHODS:Literatures were retrieved from MEDLINE,EMBASE,CNKI,CBM and Wanfang database,etc.Data of literatures were analyzed using RevMan 4.2 software.RESULTS:3 RCTs were included in meta-analysis and 1 RCT was involved in descriptive analysis.Compared with diltiazem,amlodipine was similar to benidipine in reducing the incidence of cardiovascular events;there was no statistical significance[OR=0.79,95%CI(0.57,1.10),P=0.16].Effective rate of amlodipine was significantly higher than isosorbide dinitrate,there were statistical significance[OR=7.33,95%CI(1.47,36.66),P=0.02].Compared with placebo,amlodipine could reduce occurrence times of angina significantly.CONCLUSION:Amlodipine is effective in treatment of vasospastic angina and can reduce the incidence of cardiovascular events in patients with vasospastic angina.

BACKGROUND: Saving the humeral head is a challenge when the proximal humerus is fracture in orthopedic trauma, and how to obtain medial column support is a hot topic in recent years. OBJECTIVE: To summarize the general concept, clinical significance and function, the common injury mechanism of humeral calcar, and the progress using locking plate so as to improve the clinicians' understanding for the humeral calcar and to reduce the occurrence of surgical complications. METHODS: From 2004 to 2019, Wanfang, CNKI, VIP, PubMed, Web of Science, and Springer Link about the treatment and research progress of proximal medial wall of the humerus were searched by the first author. The key words were "proximal humeral fracture, Philos, intermedial screw, calcar screw, fibular allograft, middle support" in English, and "proximal humeral fracture, humeral spur, medial column, plate, fibular allograft" in Chinese. The references were retrieved by hand. Finally, 51 studies were used for review according to the inclusion and exclusion criteria. RESULTS AND CONCLUSION: (1) The range of the humeral calcar region is still unclear. There is no uniform classification standard for fractures involving the humeral calcar region. X-ray films show that calcar fracture patterns are often inconsistent with the actual fracture situation, which is often a complex fracture. Lack of understanding and paying litter attention to the humeral calcar region is the main reason of iatrogenic injury and the failure to get a good repair. (2) Treatment using the locking plate is still the preferred method for proximal humerus fracture. Meanwhile, it is a feasible method that using the screw, the allogeneic iliac bone graft, the bone cement or the medial plate to reconstruct the medial column if there is a "repairable medial wall". Getting anatomical reduction of the internal wall and effective support of the medial column during operation can help to reduce postoperative complications. However, the use of the medial buttress plate requires further research to verify. It is critical important to repair the rotator cuff for the medial column support. (3) The range of the humeral calcar region needs to be unified. Understanding the humerus calcar is essential for the treatment of proximal humeral fracture. Only by mastering the fracture mode of the humerus calcar and choosing the most appropriate surgical procedure before surgery, meanwhile, achieving anatomical reduction of the medial wall and the effective support of the medial column during operation can reduce the postoperative complications of the fracture. Repairing of the rotator cuff carefully during operation is indispensable for patients to obtain better shoulder function.

Objective: To evaluate the short-term efficacy and the safety of FOLFOX4 regimen for patients with advanced gastric carcinoma (AGC). Methods: All of the 32 AGC patients were assessable for the safety analysis and for response. Oxaliplatin (85 mg/m2) was infused over 2 h on day 1. The leucovorin (LV, 200 mg/m2) was infused for 2 h followed by bolus (400 mg/m2) and a 22 h infusion (600 mg/m2) of 5-FU on day 1 and day 2. The treatment was repeated every 2 weeks and twice treatment as one cycle. All the patients received at least 4 cycles of treatment. Results: Of the 32 patients, 1 patient had complete response and 14 patients had partial responses (overall response rate 46.9%, 15/32). The median time to progression (TTP) was 5.6 months. The major adverse effects were mild peripheral neuropathy, nausea/vomiting and neutropenia. No treatment-related death occurred. Conclusion: FOLFOX4 regimen has good efficacy on AGC with relatively light toxicity. It could be selected as chemotherapy regimen for AGC patients.