1.Safety and effectiveness of GreenLight 120-W laser photoselective vaporization of the prostate for benign prostatic hyperplasia: A meta-analysis.
Mao DING ; Ye-qi NIAN ; Shan-biao HU ; Lu YI ; Fang-zhi CHEN ; Mou PENG ; Yin-huai WANG
National Journal of Andrology 2015;21(7):646-654
OBJECTIVETo evaluate the safety and effectiveness of GreenLight 120-W laser photoselective vaporization of the prostate (PVP) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia (BPH).
METHODSWe searched PubMed, Medline, Embase, Cochrane Library, Wanfang, CNKI, and VIP for randomized control trials and their references addressing 120-W PVP versus TURP in the treatment of BPH. Based on the inclusion and exclusion criteria, two reviewers independently accomplished the screening, quality assessment, and data extraction of the identified studies and performed meta-analyses using RevMan 5.2.
RESULTSTotally, 6 randomized control trials were included in this analysis, involving 703 cases, 351 treated by PVP and 352 by TURP. Compared with TURP, PVP showed significantly decreased time of catheterization (by 32. 55 hours, 95% CI 15.3 -49.8, P < 0.01), hospital stay (by 1.85 days, 95% CI 1.2-2.5, P < 0.01), and intraoperative blood loss (by 15.6 g/L, 95% CI 10.0-21.2, P < 0.01), but increased time of operation (by 9.37 minutes, 95% CI 5. 1-13.6, P < 0.01). There was also a significant reduction in blood transfusion, TUR syndrome, and capsular perforation in the PVP group. At 12 months after surgery, no statistically significant differences were found between the two groups in the improvement of maximum urinary flow rate, IPSS, postvoid residual, and sexual function.
CONCLUSIONGreenLight 120-W laser PVP is a safe and effective procedure for the treatment of BPH, with similar effectiveness to TURP but less blood loss, shorter time of catheterization and hospital stay, and lower incidences of blood transfusion, TUR syndrome and capsular perforation.
Blood Loss, Surgical ; Humans ; Laser Therapy ; adverse effects ; methods ; Length of Stay ; Male ; Prostate ; surgery ; Prostatic Hyperplasia ; surgery ; Randomized Controlled Trials as Topic ; Treatment Outcome
2.Development of knowledge management system for virtual teams in collaborative scientific research model
jun Hong WANG ; nian Peng LIU ; Qi SUN ; Yu ZHANG ; guang Yu WANG
Chinese Journal of Medical Library and Information Science 2017;26(9):33-37
The characteristics, status quo, design principles and implementing technology of knowledge management system for virtual teams in collaborative scientific research model were described, which was followed by an analysis of its functional system that is consisted of project management module, file management module, staff management module, communication tool model, statistical analysis module and file storage module. The developed knowledge management system for virtual teams could share the knowledge management and service, store the knowledge for a long time in the project community by integrating literature retrieval and management, experimental reports and pa-per publication, and librarians could provide sustained guidance for library holding resources and timely embedded knowledge service by joining into the project community.
3.Preliminary clinical application of Chinese-made invisible orthodontic technique.
Yu-xing BAI ; Jie TIAN ; Jie-min ZHOU ; Peng QI ; Yong-nian YAN ; Bang-kang WANG
Chinese Journal of Stomatology 2008;43(8):464-467
OBJECTIVETo treat simple malocclusions preliminarily using Chinese-made invisible orthodontic aligners and discuss the indications, problems existed and future development.
METHODSForty-one cases with different malocclusions were selected, including crowding, spaces and spaces due to periodontal problems. Invisible aligners were made and worn by patients and they were changed every 2 - 3 weeks.
RESULTSAcceptable treatment results were obtained in all cases, with nice alignments and good overbite and overjet. Treatment time ranged from 6 - 25 months.
CONCLUSIONSIndications of this technique were still limited and the technique needed to be further developed in the future.
Adolescent ; Adult ; Female ; Humans ; Male ; Malocclusion ; therapy ; Orthodontic Appliance Design ; Orthodontic Brackets ; Orthodontics, Corrective ; instrumentation ; Overbite ; Young Adult
4.Isolation of Growth-Promoting Bacteria and Effect of Compound Bacteria on Yield of Fritillaria przewalskii
Jiang ZHAO ; Shi-jun LIANG ; Tao YANG ; Xiao-long WU ; Peng-nian QI ; Shi-wei WANG ; Zhi-ye WANG
Chinese Journal of Experimental Traditional Medical Formulae 2021;27(24):163-170
Objective:To explore the effects of anti-microbial compound (T1) from
5.Herbal acupoint sticking combined with electroacupuncture therapy in the treatment of Bell's palsy: a randomized controlled trial.
Qi-Hua QI ; Shan-Shan NI ; You-Lan WANG ; Kai PENG ; He-Nian QU ; Cai-Hua YANG ; Jin WANG ; Wei XI
Chinese Acupuncture & Moxibustion 2013;33(11):965-969
OBJECTIVETo observe the clinical efficacy and safety of electroacupuncture (EA) combined with herbal acupoint sticking in the treatment of Bell's palsy and provide optimizations for the clinic.
METHODSOne hundred and two cases of Bell's palsy were randomized into an EA combined with herbal acupoint sticking group (group A, 50 cases) and an EA group (group B, 52 cases), EA at Cuanzhu (BL 2), Yangbai (GB 14), Taiyang (EX-HN 5), Quanliao (SI 18),Xiaguan (ST 7), Yingxiang (LI 20), etc. were applied in both groups and "facial paralys No.I " was applied at Yifeng (TE 17) in group A, once daily and 10 times totally were needed. The score of facial nerve function, clinical efficacy were compared before and after treatment. At 1 and 3 month follow up visit, the quality of life scale( WHOQOL-BREF) and the occurrence of complication were observed.
RESULTSThe scores of facial nerve function in group A and group B were all significantly improved compared with those before treatment (48. 2+/- 2. 9 vs 25. 7 +/- 4. 9, 45. 9 +/- 6. 2 vs 25. 8 +/- 5. 5, both P
CONCLUSIONCompared with EA, the combination of EA and acupoint sticking therapy for Bell's palsy cannot only improve the clinical efficacy and reduce the occurrence of complication but also reliable without any side effect.
Acupuncture Points ; Administration, Cutaneous ; Adolescent ; Adult ; Aged ; Bell Palsy ; drug therapy ; therapy ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Electroacupuncture ; Female ; Humans ; Male ; Middle Aged ; Treatment Outcome ; Young Adult
6.Next generation sequencing and transcriptome analysis of root bark from Paeonia suffruticosa cv. Feng Dan.
Dong-Mei XIE ; Nian-Jun YU ; Lu-Qi HUANG ; Dai-Yin PENG ; Cong-Bin LIU ; Yue-Jian ZHU ; Hao HUANG
China Journal of Chinese Materia Medica 2017;42(15):2954-2961
Moutan Cortex is an important traditional Chinese medicine, "Fengdan Pi" was known as Dao-di herbs from the root bark of Paeonia suffruticosa cv. Feng Dan for its extracted various active components. However, the genetic basis for their activity is virtually unknown. The transcriptome of the root bark from "Fengdan" was sequenced using the Illumina HiSeq 4000 sequencing platform. The clean reads were then de novo assembled into 72 997 unigenes. Among them, the number of unigenes which could been annotated by dataset Nr and GO was 41 139 and 34 592. The 20 016 unigenes could been annotated by KEGG dataset, which were involved in 5 major categories, 34 middle categories, and 352 metabolism pathways. The number of unigenes which were mapped to the phenylpropanoid biosynthesis pathway, terpenoid backbone biosynthesis pathway, terpenoid biosynthesis pathway, alkaloid biosynthesis pathway, and flavonoid biosynthesis pathway was 214, 104, 152, 55 and 36 respectively, suggesting that they are involves in these pathways of pharmaceutically important. Furthermore, there also showed remarkable differences in groups which enrichment ratio of the different expressed gene compared. In addition, a total of 9 939 SSRs were identified from the sequence of 72 997 unigenes. This study not only provides many valuable basal data which was important gene in the synthesis pathway of secondary metabolites with gene searching, but also has important significance to find molecular marker in germplasm for breeding and improvement.
7.Mechanism of Dendrobium huoshanense in Treatment of Gastric Ulcer: Based on Network Pharmacology and in Vivo Experiment
Wen-qi GUI ; Yuan FANG ; Xiao-yu LIAO ; Ji SUN ; Nian-jun YU ; Dai-yin PENG ; Lan HAN
Chinese Journal of Experimental Traditional Medical Formulae 2022;28(7):151-161
ObjectiveTo explore the mechanism of Dendrobium huoshanense in the treatment of gastric ulcer (GU) based on network pharmacology and in vivo experiment. MethodThe active components of D. huoshanense were searched from Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) and literature, and the targets of the components were screened from TCMSP and SwissTargetPrediction. GU-related genes were retrieved from GeneCards, Online Mendelian Inheritance in Man (OMIM), and DisGeNET. Thereby, the common targets of the disease and the medicinal were yielded and the protein-protein interaction (PPI) network was constructed, followed by Gene Ontology (GO) term enrichment and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. According to the predicted results, hematoxylin-eosin (HE) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA), Western blot, and real-time fluorescent quantitative polymerase chain reaction (Real-time PCR) were used to validate the effects of D. huoshanense on acetic acid-induced GU in rats. ResultA total of 63 active components of D. huoshanense and 37 target genes of D. huoshanense for the treatment of GU were screened out. PPI network analysis yielded several possible core anti-GU targets of D. huoshanense. They influenced the development of GU by acting on signaling pathways such as phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt), hypoxia inducible factor-1 (HIF-1), tumor necrosis factor (TNF), and nuclear factor-κB (NF-κB), and various biological processes. The in vivo experiment showed that D. huoshanense significantly reduced the levels of inflammatory factors such as interleukin-1β (IL-1β), interleukin-6 (IL-6), and TNF-α in the serum of model rats (P<0.05, P<0.01), increased gastric blood flow (GBF) at the ulcer margin, raised the expression of epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) at the ulcer margin (P<0.01), significantly down-regulated protein and mRNA expression of PI3K and Akt, and up-regulated protein and mRNA expression of phosphatase and tensin homolog deleted on chromosome ten (PTEN) in the gastric tissues of GU rats (P<0.01). ConclusionThrough regulating EGFR/PI3K/Akt signaling pathway, D. huoshanense can inhibit tissue inflammation, increase gastric microcirculatory blood flow at the ulcer margin, and promote cell proliferation and repair of damaged gastric mucosa.