1.Study on names of Wenyujin Rhizoma Curcumae and Rhizoma Curcumae Longae Concisa and their origins.
Yong-min CAI ; Wen-jing GUO ; Peng-fei HAO ; Juan HE
China Journal of Chinese Materia Medica 2015;40(3):560-563
To study the name of Wenyujin Rhizoma Concisum and Film Turmeric by literature research methods provide the basis for correct application of Cuba in modern clinical application. Wenyujin Rhizoma Concisum and Film Turmeric often called each other mutual generation and used as the same kind of medicine in the ancient prescriptions books. They were often recorded and stated as the same species of Curcumae Longae Rhizoma. Wenyujin Rhizoma Concisum and Curcumae Longae Rhizoma also often called each other mutual generation in the ancient prescriptions books and used as the same kind of medicine. Wenyujin Rhizoma Concisum was often recorded and stated under the Curcumae Longae Rhizoma articles in the ancient materia medica literatures. Ancient literatures on Wenyujin Rhizoma Concisum records were almost the same, the modern literatures on the records of the sources of Wenyujin Rhizoma Concisum were inconsistency. Inconsistency of Wenyujin Rhizoma Concisum source records in modern literatures was related to the changes of the modern records on source records about Curcumae Longae Rhizoma, Root-tuber of Aromatic Curcumae Longae Rhizoma and Zedoray. The author thinks that Wenyujin Rhizoma Concisum is the ancient Film Turmeric which referes to the same medicine as Curcumae Longae Rhizoma. The source of it just as the Curcumae Longae Rhizoma is not only one kind. Wenyujin Rhizoma Concisum and Curcumae Longae Rhizoma have been recorded as two medicines at the present, and the source of them simply referes to the original plant Curcuma wenyujin. When using ancient prescriptions, we need to understand the changes that Curcumae Longae Rhizoma and Wenyujin Rhizoma Concisum are the same in ancient but different today in order to choose medicine correctly in the clinical.
Curcuma
;
Medicine, Chinese Traditional
;
Rhizome
;
Terminology as Topic
2.A case report of Apert syndrome.
Hong-Hua LI ; Yun-Peng HAO ; Lin DU ; Fei-Yong JIA
Chinese Journal of Contemporary Pediatrics 2011;13(7):604-605
3.Establishment and application of HPLC-QAMS for quality evaluation of Chuanxiong Rhizoma.
Feng-xian QIAO ; Hao CAI ; Peng-fei TU ; Ke PEI ; Xiao-qing SONG
Acta Pharmaceutica Sinica 2015;50(6):749-754
A quantitative analysis method of multi-components with a single marker (QAMS) for simultaneous determination of six marker compounds (one from phenolic acids and five from phthalides) in Chuanxiong Rhizoma was established by applying HPLC and using butylidenephthalide as the internal reference substance. And also the feasibility and accuracy of the established method for quality evaluation and application of Chuanxiong Rhizoma were investigated and validated. The analysis was performed with the mobile phase consisting of acetonitrile - 0.2% aqueous formic acid. The flow rate was 1.0 mL . min-1 and the column temperature was maintained at 30 °C. The detection wavelengths were set at 252 nm (for ferulic acid, Z-ligustilide, and butylidenephthalide) and 266 nm (for senkyunolide I, senkyunolide A, and coniferyl ferulate), separately, and 20 µL was injected for analysis with gradient elution. The results showed that there were no significant differences observed between the HPLC-QAMS method and the external standard method (RSD <5%). The relative correction factors were credible (RSD < 5%) in changed chromatographic conditions. The established HPLC-QAMS method can be accurately used for simultaneously evaluating and controlling the quality of Chuanxiong Rhizoma with multi-components.
4-Butyrolactone
;
analogs & derivatives
;
Acetonitriles
;
Benzofurans
;
Chromatography, High Pressure Liquid
;
Coumaric Acids
;
Drugs, Chinese Herbal
;
analysis
;
standards
;
Hydroxybenzoates
;
Quality Control
;
Rhizome
;
chemistry
5.Pathological characteristics of the solid pseudopapillary tumor of pancreas
Dongfeng CHENG ; Baiyong SHEN ; Fei YUAN ; Bansan HAN ; Yanbo ZHU ; Xiaxing DENG ; Hao CHEN ; Jiabin JIN ; Xiaolong JIN ; Chenghong PENG
Chinese Journal of Pancreatology 2010;10(1):14-17
Objective To summarize and analyze the pathological characteristics of solid pseudopapillary tumor of pancreas (SPTs).Methods The clinical data of 51 cases of SPTs were retrospectively analyzed.The immunohistochemical localizations of different markers (HSE,SYN,CD_(56),CD_(10),Nestin,Vim,a1-ACT,EMA,AE1/AE3 and CK19) on 39 SPTs were studied.Results Pathological features included a combination of solid and cystic components with pseudopapillae formation and degenerative regions without glands.Among the 39 cases of SPTs,the expression rate of NSE was 97.4%,the expression rate of CD_(56),CD_(10) was 84.6%,the expression rate of Nestin and Vim was 64% and 87%,the expression rate of S100 was 79.5%,the expression rate of a1-ACT and a1-AT was 82.1% and 79.5%,while the expression rate of SYN was 12.8%;however there was low expression and weak positive reaction of EMA,AE1/AE3 and CK19.Conclusions The typical pathological characteristics of SPTs may result from gradual degenerative changes induced anoxemia in some SPT's areas.The heterogeneity of SPTs on different antibody markers showed that the SPTs may be originated from pancreatic embryonic stem cells,and result from immature differentiation of the pluripotential stem cells during pancreatic genesis.
6.Differentiation Study of Chinese Medical Syndrome Typing for Diarrhea-predominant Irritable Bowel Syndrome Based on Information of Four Chinese Medical Diagnostic Methods and Brain-gut Peptides.
Hao-meng WU ; Zhi-wei XU ; Hai-qing AO ; Ya-fei SHI ; Hai-yan HU ; Yun-peng JI
Chinese Journal of Integrated Traditional and Western Medicine 2015;35(10):1200-1204
OBJECTIVETo establish discriminant functions of diarrhea-predominant irritable bowel syndrome (IBS-D) by studying it from quantitative diagnosis angle, hoping to reduce interference of subjective factors in diagnosing and differentially diagnosing Chinese medical syndromes of IBS-D.
METHODSA Chinese medical clinical epidemiological survey was carried out in 439 IBS-D patients using Clinical Information Collection Table of IBS. Initial syndromes were obtained by cluster analysis. They were analyzed using step-by-step discrimination by taking information of four Chinese medical diagnostic methods and serum brain-gut peptides (BGP) as variables.
RESULTSClustering results were Gan stagnation Pi deficiency syndrome (GSPDS), Pi-Wei weakness syndrome (PWWS), Gan stagnation qi stasis syndrome (GSQSS), Pi-Shen yang deficiency syndrome (PSYDS), Pi-Wei damp-heat syndrome (PWDHS), cold-damp disturbing Pi syndrome (CDDPS). Of them, GSPDS was mostly often seen with effective percentage of 34. 2%, while CDDPS was the least often seen with effective percentage of 5.5%. A total of 5 discriminant functions for GSPDS, PWWS, GSQSS, PSYDS, and PWDHS were obtained by step-by-step dis- crimination method. The retrospective misjudgment rate was 4.1% (16/390), while the cross-validation misjudgment rate was 15.4% (60/390).
CONCLUSIONThe establishment of discriminant functions is of value in objectively diagnosing and differentially diagnosing Chinese medical syndromes of IBS-D.
Alarmins ; Brain ; Cluster Analysis ; Diarrhea ; classification ; diagnosis ; Hot Temperature ; Humans ; Irritable Bowel Syndrome ; classification ; diagnosis ; Medicine, Chinese Traditional ; Qi ; Retrospective Studies ; Surveys and Questionnaires ; Yang Deficiency
7.Puncture effect of the intervertebral foramen under the guidance of imaging equipment
Yun-Fei PENG ; Hao YOU ; Dong ZHANG
China Journal of Endoscopy 2018;24(2):80-84
Objective To explore the effect of intervertebral foramen puncture under image equipment guidance. Methods 52 patients with lumbar disc herniation from January 2014 to January 2017 were enrolled in this study. All the patients underwent lumbar posterior lateral approach for endoscopic surgery. Patients were divided into control group and observation group by random number table method, 26 patients in each group. The patients in the observation group were treated with ultrasound volume, and the patients in the control group were treated with C arm X-ray machine. The intraoperative condition, preoperative and postoperative visual analogue scale (VAS score), Oswestry dysfunction index (ODI score) and postoperative complications were compared between the two groups. Results The operation time, the total time of puncture and the number of fluoroscopy were lower in the observation group than that in the control group. The patients in the observation group and the control group were treated before operation, 1 month after operation, 3 months after operation, 6 months after operation and there was no statistically significant difference in VAS score and ODI score between 12 months (P > 0.05). The patients in the observation group and the control group had no significant complication after operation. Although they had pain symptoms, they could be relieved by themselves or by drug treatment. Conclusion Ultrasonic volume navigation can enhance the accuracy of puncture and reduce the puncture time, and there is no significant complication after operation. The safety is better than that of C arm X-ray machine.
8.Analysis of the research status and intervention strategies for the treatment of hepatic encephalopathy based on gut microbiota regulation
Jia-ting YIN ; Yin PENG ; Wen-hao XU ; Meng-fei MAO ; Jin-ao DUAN ; Jian-ming GUO
Acta Pharmaceutica Sinica 2021;56(4):895-905
Hepatic encephalopathy is a common metabolic neuropsychiatric syndrome in the development of end-stage liver disease. Since the concept of intestinal-liver-brain axis was proposed, the relationship between the pathogenesis of hepatic encephalopathy and the gut microbiota has been a hot research topic. In recent years, studies have confirmed that gut microbiota is involved in and affects various pathological processes of hepatic encephalopathy. This article combines the latest research progress at home and abroad to elaborate on the research status of regulating gut microbiota and thus interfering with the pathological process of hepatic encephalopathy, hoping to provide new ideas and methods for the intervention of hepatic encephalopathy based on the regulation of gut microbiota.
9.Surgical treatment for abdominal aortic aneurysm in 46 cases
Jieqiu LI ; Hongzhi XIA ; Xueming CHEN ; Hanjun LI ; Xiaofeng XIE ; Fei LIU ; Jianjun GE ; Hao PENG ; Ping KONG
Chinese Journal of General Surgery 1997;0(06):-
Objective To study how to improve the safety of the operation for abdominal aortic aneurysm(AAA).Methods Forty-six cases of AAA received resection of AAA plus artificial blood vessel transplantation in recent three and a half years in our 2 hospitals.The lesions involved only the abdominal aorta in 20 cases,and extended to unilateral common iliac and internal and external iliac arteries in 8 cases,to bilateral common iliac and external and internal iliac arteries in 16 cases,and involved the renal artery in 2 cases.Emergency operation was done in 3 cases.Results In these 46 cases,45 were cured and 1 died,and no operative complications occurred.Conclusions Surgical operation is the best way to treatment AAA.
10.Analysis of the genetic stability of the master virus seeds for live attenuated influenza vaccine produc-tion
Lihong LIU ; Yang ZANG ; Hao JIANG ; Fei XU ; Changlin ZHU ; Peng GE ; Xintao LIU ; Yan ZHANG ; Chunlai JIANG
Chinese Journal of Microbiology and Immunology 2015;(4):281-285
Objective To analyze the genetic stability of master virus seed lots of live attenuated influenza vaccineA/17/California/2009/38(H1N1)andA/17/Perth/09/87(H3N2)strains.Methods The master virus seed lots were inoculated into chicken eggs for subculture.The complete genome of the 2nd, 3rd, 5th and 10th generations of viruses were amplified and sequenced.The genes encoding hemagglu-tinin ( HA) and neuraminidase ( NA) were compared with those of the WHO recommended circulating wild-type virus strains used for vaccine production in northern hemisphere during 2011-2012 influenza season.Six internal genes (PB2, PB1, PA, NP, M and NS) of each virus generation were compared with their master donor virus strain (A/Leningrad/134/17/57) for the evaluation of the genetic stability.Results The muta-tion rates of H1N1 and H3N2 strains after 10 passages were 0.035%and 0.022%, respectively.No muta-tions were found at the critical sites for controling thecold adapted ( ca) , temperature sensitive ( ts) and at-tenuated ( att) phenotypes.Conclusion The live attenuated influenza vaccine strains possessed high genet-ic stability as their tenth generations still shared 99% of homology with the original seed lots.All of the working virus seed lots met the requirements of Pharmacopoeia of the People′s Republic of China ( 2010 edition) .