Objective To compare the effects of vasopressin and adrenaline on cerebral resuscitation in rats. Method Sixty male SD rats were used to set the animal model of cardiac arrest and were randomly (random number) divided into 4 groups (n = 15/group): sham operation group (sham-gro), negative control group (neg-gro), vasopressin group (vas-gro) and adrenaline group (adr-gro). Blood pressure was recorded, and brain tissue samples were obtained. Results There was no significant difference in the recovery rate between vas-gro and adr-gro 30 min after resuscitation (P ＜0.05). The mean blood pressure in vasgro was higher than that in adr-gro within 30 min (1,2, 5, 10, 20, 30 min) after restoration of spontaneous circulation. The measured MDA, SOD and GSH were significantly different (P ＜ 0.05) between each two groups among vas-gro, sham-gro and adr-gro. Conclusions The recovery rate was similar between vasopressin group and adrenaline group during cardiopulmonary resuscitation in rats. However, vasopressin can to maintain the mean arterial pressure at a higher level after resuscitation, which can the increase the cerebral perfusion and reduce brain cell damage.

The characteristics of medical and health literature novel assessment in institutions of armed forces were described from the secrecy of projects for literature novelty assessment , the limitations of consignee institution , and the non-profitability of literature novelty assessment agency .The major problems of medical and health literature novel assessment in institutions of armed forces were elaborated in terms of the literacy, instability, competency and knowledge limitation of literature novel assessment staff with suggestions put forward for their solution such as strengthening the construction of talent team, joint development and sharing of resources.

BACKGROUND: Studies have shown that Maca can enhance immune cel function, improve mitochondrial respiratory chain enzymes, and play a role in anti-oxidation and anti-aging.
OBJECTIVE: To observe Maca effects on kidney mitochondrial respiratory function and anti-aging capabilities in elderly rats after exhausted exercise.
METHODS: 10-month-old elderly rats were intragastrical y administrated Maca powder 5 g/kg, once a day, and did treadmil exercise, 5 days in a week. Rats were randomly divided into control group, Maca group and training group and Maca+training group. At 6 weeks after training, rats in each group did exhausted exercise (35 m/min), and immediately received intraperitoneal injection of 2% sodium pentobarbital. The kidney was obtained, and mitochondria were extracted by differential centrifugation. A spectrophotometer was used to measure mitochondrial respiratory chain activity.
RESULTS AND CONCLUSION: (1) Mitochondrial respiratory chain enzyme and antioxidant enzyme activity: mitochondrial respiratory chain enzyme I-III, superoxide dismutase and glutathione peroxidase activities were higher in the Maca+training group than in the control group, Maca group and training group (P < 0.05 or P < 0.01), but malondialdehyde content was lower (P < 0.05 or P < 0.01). (2) Results suggested that the combination of supplement Maca and incremental exercise can improve mitochondrial respiratory function and delay aging in the kidney of aged rats after exhausted exercise. Moreover, supplemented Maca and incremental exercise have a synergistic effect.

Reviewing the theory of chaos in the field of nonlinear dynamics, this paper summarized theory of chaos and its applications in medical signal processing including electroencephalogram(EEG) signal?electrocardiogram(ECG) signal?electromyogram(EMG) signal, etc. The foreground is reviewed to advance the study and application of nonlinear dynamics theory in biomedical engineering.

Objective To explore the effects of estrogen,sport walking with weight and estrogen plus sport walk on serum lipid,bone metabolism and bone mineral density(BMD) in postmenopausal women.Methods 52 postmenopausal women were divided into the hormone replacement therapy(HRT) group(n=12),sport walking with weight group(Sp group,n=14),HRT + Sp group(n=12) and control group(n=14).HRT group took compound nylestriol,Sp group took sport walking with 5 kg weight and exercise intensity was from 60% to 80% VO2max,HRT+Sp group received two treatments as HRT group and Sp group.The experimental duration consisted of six months.Results The total cholesterol(TC),TC/high density lipoprotein cholesterol(HDL-C),alkaline phosphatase(APL) and urine calcium(Ca)/creatinine(Cr) were markedly lower in three experimental groups than the control group and before experiment(P<0.05 or P<0.01),HDL-C in Sp and HRT+Sp groups were markedly higher than the control group and before experiment(P<0.05),BMD of spine(L2～L4) and left trochanter in three experimental groups were markedly higher than the control group(P<0.01) and before experiment(P<0.0).Conclusion Both estrogen replacement therapy and sport walking with weight effectively improve serum lipid,prevent and reverse osteoporosis induced by menopause in women.

Acupuncture Therapy ; Acute Disease ; therapy ; Administration, Cutaneous ; Adult ; Combined Modality Therapy ; Drugs, Chinese Herbal ; administration & dosage ; Female ; Humans ; Lactation ; Massage ; Mastitis ; drug therapy ; physiopathology ; therapy ; Young Adult

Endometrial Neoplasms ; classification ; epidemiology ; mortality ; pathology ; Female ; Humans ; Uterine Cervical Neoplasms ; classification ; epidemiology ; mortality ; pathology

Objective To study the effect of pravastatin on cardiac function and serum C-reactive protein (CRP) levels in patients with chronic heart failure (CHF). Methods 90 patients with CHF were randomly divided into pravastatin group (n=45) and control group (n=45). Pravastatin 40mg/d was administered in addition to the routine treatment for pravastatin group; the control group was received the routine treatment. All patients with CHF were examined serum CRP levels, LVEF at pretherapy and 3 months by ultrasonic cardiogram. Results At 3 months C-reactive protein levels were degraded in varying degree, and the serum CRP levels in pravastatin group was significantly lower than that in control group [(15.47±9.83)mg/L vs (20.31±7.15)mg/L](P<0.05), LVEF was significantly higher than that in control group[(45.70±7.01)% vs (38.34±5.31)%](P<0.05); the serum CRP levels was positively related to LVEF (r=-0.495,P<0.05). Conclusion Pravastatin may improve the prognosis in patients with CHF, and can be used as a sensitive index for pravastatin treatment of CHF.

Viral infection begins with the entry of the virus into the host target cell and initiates replication.For this reason,the virus entry machinery is an excellent target for antiviral therapeutics.In general,a virus life cycle includes several major steps: cell-surface attachment,entry,replication,assembly,and egress,while some viruses involve another stage called latency.The early steps of the virus life cycle include virus attachment,receptor binding,and entry.These steps involve the initial interactions between a virus and the host cell and thus are major determinants of the tropism of the virus infection,the nature of the virus replication,and the diseases resulting from the infection.Owing to the pathological importance of these early steps in the progress of viral infectious diseases,the development of inhibitors against these steps has been the focus of the pharmaceutical industry.In this review,Herpes Simplex Virus(HSV),Hepatitis C Virus(HCV),and Human Enterovirus 71(EV71)were used as representatives of enveloped DNA,enveloped RNA,and non-enveloped viruses,respectively.The current mechanistic understanding of their attachment and entry,and the strategies for antagonist screenings are summarized herein.

The cancer pain is an important factor affecting life quality of patients with cancer. It has a complex mechanism,The key of treatment is based on the cancer painful etiology which involved chemotherapy, radiotherapy,surgery, analgetic drug, traditional Chinese medicine and remedies, cognitive psychology and so on. Effective treatments may alleviate the cancer pain, and improve the quality of life of patients. It is an impor-tant measure of alleviating cancer pain to select an individual therapeutic schedule and combine an evaluation of cancer pain from clinicians.