Objective: To investigate the diagnostic value of combined examination of copeptin and high sensitivity cardiac troponin T (hs-cTnT) in patients at the early stage of acute myocardial infarction (AMI) . Methods: A total of 272 patients were enrolled in this study, all of them suffered from chest pain and admitted within 4 hours. The patients were divided into 4 groups according to coronary artery angiography (CAG) results. Control group, the patients with normal CAG,n=64, UAP group (unstable angina pectoris),n=50, STEMI group,n=82, NSTEMI group,n=76. All patients received in-hospital observation, plasma levels of copeptin and hs-cTnT were examined at admission and at 6 hours after the chest pain respectively. Results: Within 4 hours of chest pain, combined examination of copeptin and hs-cTnT had the higher sensitivity for diagnosing AMI than a single detection of hs-cTnT with the cut-off point of hs-cTnT ≤ 14ng/L and Copeptin < 14pmol/L. In NSTEMI group, the AUC (area under curve) for combined examination was 0.97 (95% CI 0.88-0.99), AUC for single hs-cTnT detection was 0.75 (95% CI 0.62-0.87),P<0.05. In STEMI group, the AUC for combined examination was 0.97 (95% CI 0.88-0.99), AUC for single hs-cTnT detection was 0.74 (95% CI 0.60-0.88),P< 0.05. The AUC for combined examination of copeptin and hs-cTnT in diagnosing early AMI was 0.912 (95% CI 0.812-0.961) which was higher than single detection of hs-cTnT, AUC 0.851 (95% CI 0.713-0.936), Z=2.553,P<0.05. Conclusion: Combined examination of copeptin and hs-cTnT had the higher sensitivity and accuracy for diagnosing the patients at the early stage of AMI, it may help the risk stratiifcation of chest pain which is valuable in clinical practice.

Benzene ; Benzene Derivatives ; Bile ; Chromatography, Gas ; Gallbladder ; Gas Chromatography-Mass Spectrometry ; Humans ; Toluene

The new cataloguing rules, RDA, have been implemented in NLM and more RDA bibliographic data can thus be accessed in domestic medical libraries when the Western documents are catalogued by offloading their bibliographic data.The differences in RDA and AACR2 were compared, the common modified fields and descrip-tive contents were described when the RDA bibliographic data were changed into AACR2 bibliographic data in order to provide certain reference for cataloguing of Western documents using the RDA bibliographic data.

Five compounds were isolated from the rhizome and roots of Rhodiola crenulata S.H.Fu.They werc identified as rhodionin (Ⅰ), rhodiosin(Ⅱ), tyrosol(Ⅲ), salidroside(Ⅳ) and gallic acid (Ⅴ), respectively, by UV, MS, 1H and 13CNMR spectroscopic and chemical reactions.

Animals ; Carnitine ; pharmacology ; H(+)-K(+)-Exchanging ATPase ; metabolism ; Mitochondria, Muscle ; enzymology ; Muscle, Skeletal ; drug effects ; Physical Conditioning, Animal ; Rats

Objective To investigate quality of life and its influencing factors among elderly women with urinary incontinence(UI) living at nursing homes in Beijing. Method A randomized method was used to select six districts in Beijing. All the nursing homes in these 6 districts were included in our study,642 eligible elderly women participated in the survey. Quality of life of 244 women who were identified with different type UI were assessed. Bivariate analysis and multiple analysis were performed. Results The average score of quality of life was 8.5 ± 6.6. Scores of social embarrassment, activity & limiting behavior, psychosocial impacts were 1.8 ± 1.4,4.0 ± 3.5 and 3.3 ± 2.7 respectively. In bivariate analysis, significant differences were found by type of UI, severity of UI,course of UI, health condition, income level and self-care ability. In multiple analysis after adjustment of other variables, UI course≥5 years and inability to take care of herself were risk factors of quality of life.Conclusion Quality of life of elderly women with UI is poor, specific nursing and treatment should be conducted.

Objective To evaluate prevalence and risk factors of urinary incontinence(UI)among aged women living at nursing homes in Beijing,and provide references of relative health strategy.Methods Totally 642 women aged 60 years and over were randomly selected at nursing homes from 6 districts in Beijing.A questionnaire survey was conducted using International Consultationon Incontinence Questionnaire Female Lower Urinary Tract Symptoms Module (ICIQFLUTS) recommended by International Consultation on Incontinence (ICI).Results The prevalence rate of UI was 38.0％ (244/642) among whom 38.5％ (94/244) of participants knew their health conditions,7.8％ (19/244) visited hospital and 6.6％ (16/244) received medical or operational treatment.The proportions of respiratory disease ( 27.0 ％ vs.14.6％),digestive disease (23.4％vs.15.3％),urological disease(24.6％vs.8.5％),cardio-cerebralvascular disease(74.2％ vs.53.5％),neurological disease ( 9.4 ％ vs.5.0％),obstetric disease ( 27.5％ vs.10.1％),menstrual disorder (21.4％vs.14.4％),getting married before aged 21 years (51.5％vs.40.8％),being pregnant more than 4 times(50.2％vs.40.9％),the experience of both cesarean and natural birth (4.0％vs.0.8％),constipation(40.2％ vs.29.4％),fecal incontinence ( 13.1％ vs.4.0％),uneasy movement ( 22.5％vs.10.6％) and drinking (8.6％vs.3.5％) were higher in women with UI than in women without UI (P＜0.05 or P＜0.01).Eight risk factors that were entered into logistic regression model included getting married before 21 years old (OR =1.5,95 ％ CI:1.0-2.3,P＜0.05),being pregnant more than 4 times(OR=1.7,95％CI:1.1-2.4,P＜0.05),menstrual disorder(OR=1.7,95％CI:1.0-2.7,P＜0.05),respiratory disease(OR=1.6,95 ％CI:1.0-2.6,P＜0.05),urological disease(OR=2.4,95 ％CI:1.4-4.1,P＜ 0.01 ),cardio-cerebralvascular disease ( OR =2.0,95 ％ CI:1.3-3.0,P ＜ 0.01 ),obstetric disease(OR=3.4,95％CI:2.0-5.6,P＜0.01),moving uneasily(OR=2.5,95％CI:1.5-4.0,P＜0.01).Conclusions UI is a common disease among women residing at nursing homes.Specific measures including intervention and clinical treatment targeting risk factors should be conducted.

Objective To assess the feasibility of heterogeneous acellular dermal matrix(ADM)seeded with adipose derived stem cells(ADSC)for urethroplasty in a rabbit model.Methods ADSC were isolated from a rabbit and expanded in vitro,then identified by flow cytometry.We seeded ADSC onto the ADM and made it into tissue-engineered urethra.12 male rabbits were removed 1 cm urethra and divided into experiment group and control group.There were 6 rabbits in each group.Reconstructed urethra with tissueengineered urethra was used in experiment group,while unseeded ADM were used in control group.Urethrography was performed at 6 months after surgery.The animals were scarified at 3 and 6 months after surgery and the repaired urethra were harvested.H&E staining and immunohistochemical staining were performed with cytokeratin AE1/AE3 and smooth muscle desmin makers.Results The morphology of isolated ADSC was with long spindle cross-links,and had multicentral growth.Flow cytometry showed that the ADSC expressed CD166,CD105,CD90 and CD44,but not expressed CD45 and CD13.The cells could growth well on the ADM and showed good biocompatibility with it.All animals could void normally,urethrography showed there was no significant stenosis.3 months after surgery,the experiment group appeared regenerated smooth muscle but not in the control group,both groups did not regenerate urothelium.At 6 months urothelium and smooth muscle cells could be observed in the experiment group,but only the smooth muscle was evident in the control group.Conclusions By applying tissue engineering methods,we can seed the ADSC onto the heterogeneous ADM and make it into tissue-engineered urethra,which can help improve the reconstructive effect of urethra.

ObjectiveAim at the problems in the treatments of the children malignant bone tumor of distal femur,we put forward the concept of the dual mobility hemi-knee prosthesis and try to perform the motion parameters analysis and the pilot clinical trials.MethodsBase on the CT data from samples of knee joint in adult,we adopted the Mimics/Geomagic/Pro-E software and computer numerical control milling machine technology to design and produce the dual mobility hemi-knee artificial prosthesis,and then motion parameters was analyzed in vitro test,and at last pilot clinical trial was performed.ResultsIn vitro experiment showed that the displacement of the internal femoral condyle flexion facet center was(2.59±0.43) mm in normal knee group,(2.22±0.52) mm in dual mobility hemi-knee prosthesis group,and (1.18±0.43) mm in total knee arthroplasty group; the displacement of the external femoral condyle flexion facet center was (11.95±6.62) mm in normal group,(11.25±6.19) mm in dual mobility hemi-knee prosthesis group,and (1.26±0.42) mm in total knee arthroplasty group; the maximum relative rotation angle was 13.17°±7.58° in normal knee group,11.69°±6.49° in dual mobility hemi-knee prosthesis group,and 5.40°±1.29° in total knee arthroplasty group.After that,we accomplished the pilot clinical trials successfully for a patient with malignant bone tumor in distal femur.The patient recovered well and the treatment outcome was satisfactory.ConclusionThe motion parameters analysis showed that the motion mode of the dual mobility hemi-knee prosthesis is similar with that of the normal knee.The dual mobility hemi-knee prosthesis provides a whole new concept and method for the treatment of malignant bone tumor of distal femur in children,and the device and concept of ligament reattachment provide a solution to the reconstruction of knee ligament.

Aged ; Carcinoma, Hepatocellular ; diagnostic imaging ; pathology ; surgery ; Hepatectomy ; methods ; Humans ; Liver Neoplasms ; diagnostic imaging ; pathology ; surgery ; Male ; Middle Aged ; Tomography, X-Ray Computed