BACKGROUND

Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are rare, chronic autoimmune blistering diseases primarily treated with systemic glucocorticoids. Long-term use of glucocorticoids can result in significant adverse effects, leading to the exploration of steroid-sparing adjuvants. This meta-analysis aimed to evaluate the efficacy and safety of glucocorticoids alone versus in combination with adjuvants for treating PV and PF.

The main objective of this study was to compare the efficacy and safety of oral glucocorticoids alone versus with steroid-sparing adjuvants in treatment of PV and PF.

This research was a systematic review and quantitative meta-analysis of randomized controlled trials (RCTs) that compared systemic glucocorticoids with or without steroid-sparing adjuvants in treating PV and PF. A total of 20 RCTs were included after meeting the inclusion criteria, comprising 1169 patients diagnosed with PV or PF. Primary outcomes were remission rates, while secondary outcomes included relapse rates, disease control, and the occurrence of adverse events.

Studies involving rituximab and cyclophosphamide demonstrated significantly higher remission rates compared to other adjuvants or glucocorticoid monotherapy. Adverse events were common, particularly with high-dose glucocorticoids.

The meta-analysis found that rituximab and cyclophosphamide were superior steroid-sparing adjuvants in the treatment of PV and PF. Other adjuvants, such as azathioprine and mycophenolate mofetil, also showed efficacy but had a higher incidence of adverse events. Further studies were needed to optimize treatment protocols and reduce long-term complications.

No abstract available.
Pemphigus

No abstract available.
Pemphigus

No abstract available.
Pemphigus*

No abstract available.
Pemphigus

Pemphigus foliaceus (PF) is a chronic, benign, acquired autoimmune blistering disease characterized by fragile, superficial blisters and bullae.1 2 3 Patients commonly report blister formation on the skin, followed by localized lesions that typically begin on the trunk, face, or scalp.2 PF is a rare disease with a very low worldwide incidence and prevalence. However, it has a high incidence in endemic areas located in North Africa, Brazil, Colombia, and Peru.2 3 4 The disease affects both sexes equally, with symptoms typically appearing between the ages of 50 and 60 years.2 4 The universal type of PF that occurs sporadically is idiopathic, while the endemic type is linked exclusively to geographically-related environmental factors.
Pemphigus

No abstract available.
Pemphigus ; Shock

No abstract available.
Pemphigus* ; Psoriasis*

No abstract available.
Pemphigus* ; Pregnancy*

No abstract available.
Nose ; Pemphigus