1.A Case of Wolf's Isotopic Response Presenting as Bullous Pemphigoid.
Seung Hyun CHUN ; Bo Young KIM ; Chang Min KIM ; Jae Beom PARK ; Hwa Jung RYU
Annals of Dermatology 2017;29(4):499-500
No abstract available.
Pemphigoid, Bullous*
2.Atypical Variant of Bullous Pemphigoid: Prolonged Eruptions of Papulourticarial Lesions.
Chang Woo LEE ; Tchae Sik NAM ; Jae Hong KIM ; Joong Hwan KIM
Annals of Dermatology 1989;1(1):33-36
No abstract available.
Pemphigoid, Bullous*
3.The Association Between Bullous Pemphigoid and Neurological Disorders in A Selected Malaysian Population
Zhenli Kwan ; Yit Nian Lai ; Chin Chwen Ch’ng ; Ai Huey Tan ; Leng Leng
The Medical Journal of Malaysia 2015;70(2):81-85
Background: An association of bullous pemphigoid with
neurological disorders has been reported. The objectives of
this study were to review the clinical characteristics of
patients with bullous pemphigoid and compare the
association between bullous pemphigoid and various
neurological disorders and comorbidities.
Methods: This was a retrospective case-control study
involving 43 patients with bullous pemphigoid and 43 age-,
sex- and ethnicity-matched controls.
Results: There was a statistically significant association
between bullous pemphigoid and neurological disorders
[Odds Ratio (OR) = 3.5, 95% Confidence Interval (CI) 1.3 to
9.2, p=0.011 and adjusted OR=3.5, 95% CI 1.2-10.3, p=0.026],
in particular for dementia (p=0.002). Although stroke was
more common among patients with bullous pemphigoid,
this association was not statistically significant with OR of
1.9 (95% CI 0.7 to 5.2) and adjusted OR of 2.1 (95% CI 0.6 to
7.2). Similarly both ischaemic stroke (OR 1.5, 95% CI 0.5 to
4.2) and haemorrhagic stroke (OR 1.5, 95% CI 0.2 to 9.7) were
more common. Other neurological disorders more common
among patients with bullous pemphigoid were Parkinson’s
disease and epilepsy. Dyslipidaemia was significantly less
common among patients with bullous pemphigoid (OR 0.4,
95% CI 0.1 to 0.9, p=0.033).
Conclusion: A combination of an inflammatory process,
prothrombotic state and endothelial activation leads to an
increased frequency of neurological disorders among
patients with bullous pemphigoid. Thus, a holistic approach
to patient care, including screening for dementia and control
of comorbidities, should be practised as bullous
pemphigoid affects more than just the skin.
Pemphigoid, Bullous
4.Childhood bullous pemphigoid: A case report
Gemma Theresa C. David-Corpuz ; Cathrine B. Ang ; Camille B. Angeles ; Maria Jasmin J. Jamora ; Lian C. Lian C. Jamisola
Journal of the Philippine Dermatological Society 2022;31(2):44-47
Introduction:
Bullous pemphigoid (BP) is an acquired autoimmune subepidermal bullous disease characterized by linear depo-
sition of IgG and C3 along the basement membrane. It rarely occurs in childhood, especially in adolescence, with only 14 cases
identified in literature. Treatment of choice is systemic corticosteroids but other treatment options such as anti-inflammatory
antibacterials and methotrexate are available.
Case report:
A 16-year-old Filipino girl presented with a three-month history of generalized vesicles and bullae. Nikolsky and
Asboe-Hansen signs were negative. Histopathology and direct immunofluorescence were consistent with BP. ELISA to BP180 au-
toantibody levels was elevated at 135 IU (normal <9 IU). Complete blood count showed leukocytosis with increase in neutrophils.
Chest x-ray revealed pulmonary tuberculosis. The patient was given quadruple anti-Koch’s medication (pyrazinamide, rifampi-
cin, ethambutol, isoniazid), prednisone, oral erythromycin and topical clobetasol propionate. Complete remission was attained
at 10 months and is sustained at the time of writing.
Conclusion
To establish a definitive diagnosis and appropriate management, BP requires clinical, histopathologic, and immuno-
logical correlation. Childhood BP has good prognosis and rapid treatment response, with rare relapses.
Pemphigoid, Bullous
5.A literature review and clinical consensus guidelines on the management of Bullous Pemphigoid
Clarisse G. Mendoza ; Josef Symon S. Concha ; Cybill Dianne C. Uy ; Bryan K. Guevara ; Evelyn R. Gonzaga ; Maria Jasmin J. Jamora ; Jamaine L. Cruz‑Regalado ; Katrina C. Estrella ; Melanie Joy D. Ruiz ; Rogelio A. Balagat ; Mae N. Ramirez‑Quizon ; Johanna Pauline L. Dizon ; Marie Eleanore O. Nicolas
Journal of the Philippine Dermatological Society 2023;32(2):63-76
Bullous pemphigoid (BP) is the most common autoimmune blistering disease primarily characterized by
tense blisters and occasionally with urticarial plaques, affecting the skin and mucous membranes. These are
caused by autoantibodies against BP180 and BP230 which target antigens on the basement membrane zone.
The diagnosis relies on the integration of clinical, histopathological, immunopathological, and serological
findings. The management depends on the clinical extent and severity. We present in this article a literature
review and the clinical consensus guidelines of the Immunodermatology Subspecialty Core Group of the
Philippine Dermatological Society in the management of BP.
Pemphigoid, Bullous
6.Childhood Bullous Pemphigoid with atypical immunopathology: A case series
Jennifer C. Li ; Rio Mae Timon Gabriel ; Ma. Desiree Hannah C. Garcia ; Ma. Fatima Lourdes Omangayon ; Clarisse G. Mendoza ; Gisella E. Umali‑Adasa
Journal of the Philippine Dermatological Society 2024;33(1):33-37
Bullous pemphigoid (BP) is a rare autoimmune blistering disorder primarily affecting older adults, with
limited occurrences in children. BP in children typically manifests as large, tense blisters on the skin, often
on flexural areas. It also more often affects the oromucosal areas and the face in children than in adults.
Diagnosis involves histopathological examination revealing eosinophilic spongiosis or subepidermal split,
immunofluorescence tests highlighting immunoglobulin G (IgG) and C3 depositions, and immunological
assays detecting BP180 and BP230 IgG autoantibodies. This report presents two cases of childhood BP (CBP)
with atypical immunopathological findings. Clinically, the two cases had generalized plaques and bullae,
including the face. The first case exhibited the characteristic linear deposits of IgG and C3 on the basement
membrane through direct immunofluorescence (DIF) and revealed negative anti‑BP180 antibodies on
enzyme‑linked immunosorbent assay (ELISA). In contrast, the second case showed negative DIF results,
despite clinical suspicion, but had positive anti‑BP180 IgG antibodies on ELISA. It is, therefore, crucial to
consider the complete clinical presentation of the patient, in conjunction with the histological findings
and immunopathologic assessments to diagnose CBP.
Pemphigoid, Bullous
7.A Case of Dyshidrosiform Pemphigoid.
Yong Seob AHN ; Chan SAGONG ; Hee Joon YU ; Joung Soo KIM
Korean Journal of Dermatology 2007;45(5):492-495
Several clinical variants of bullous pemphigoid have been described (e.g. generalized, vesicular, nodular, polymorphic, vegetans, and localized). Dyshidrosiform pemphigoid is an unusual form of the localized variant of bullous pemphigoid, and was first described in 1979. It presents with a localized, persistent, vesicobullous eruption similar to dyshidrosiform dermatitis. Herein, we report a case of dyshidrosiform pemphigoid which presented with bullae localized to both the palms and soles.
Dermatitis
;
Pemphigoid, Bullous*
8.Coexistence of Bullous Pemphigoid and Psoriasis: A Case Report and Review of the Literature.
Seok Beom PARK ; Jin Ho CHUNG ; Jai il YOUN
Annals of Dermatology 1999;11(1):23-26
There have been several reports in the literature of coexistent psoriasis and bullous pemphigoid. In most cases, the bullous pemphigoid lesions have been considered to be induced by antipsoriatic treatments. We describe a patient with psoriasis in whom bullous pemphigoid developed during psoriasis treatment, but the exact etiologic factor was not identified. Recently, some reports have suggested that an immunologic or biochemical association between the two diseases plays a role in the pathogenesis.
Humans
;
Pemphigoid, Bullous*
;
Psoriasis*
9.Concurrent Bullous Pemphigoid and Pemphigus Vulgaris
Jae Seong JOO ; Sook Jung YUN ; Seung Chul LEE ; Jee Bum LEE
Korean Journal of Dermatology 2019;57(9):569-570
No abstract available.
Pemphigoid, Bullous
;
Pemphigus
10.Erythema Multiforme like Bullous Pemphigoid.
Yun Sun MOON ; Do Seon JEONG ; Hae Bong JEONG ; Chi Yeon KIM
Korean Journal of Dermatology 2017;55(3):212-213
No abstract available.
Erythema Multiforme*
;
Erythema*
;
Pemphigoid, Bullous*