Objective To evaluate the effect of cutting balloon angioplasty and stent implantation on serum TNF ?, IL 6 and IL 8, and investigate the relationship between the concentrations of serum TNF ?, IL 6 and IL 8 after operation and the incidences of late cardiac events after intervention Methods Eighty patients underwent PTCA with normal balloon or cutting balloon Values of serum TNF ?, IL 6 and IL 8 before and after intervention were measured using enzyme linked immuno sorbent assay Results The concentrations of serum TNF ?, IL 6 and IL 8 were increased significantly in the restenosis group, especially in the POBA group There was no obvious difference in no restenosis group Conclusion The lower restenosis rate in cutting balloon group was related to its lower injury and inflammation of blood vessels The concentrations of serum TNF ?, IL 6 and IL 8 6 hours after intervention may be the predictable sign of restenosis after intervention

Objective To evaluate the clinical significance of the serum lactic dehydrogenate(LDH) and ?2-Microglobulin(?2-MG) measuring in N0n-Hodgkins Lymphoma(NHL) Patients.Methods The LDH and ?2-MG are collected from 126 NHL patients and measured by rate method and radioimmunoassay respectively.Results The 2-year survial,4-year survial and alleviation rate of Patientsinnormat LDH and ?2-MG level group were obviously higher than those intevel increasing group.Difference is of significance(p

Objective To identify the genotypos of extended spectrum β-1actamase (ESBLs)-producing of Escherichia coli ( E. coli) clinical strains isolated from the Macao and compare the results with the genotypes of clinical strains collected in the first Clinical College, China Medical University (CMU) in Shengyang. Methods The clinically isolated E. coli strains including 209 strains from Macao and 150 strains from CMU were collected. Based on the standard of CLSI2006, the ESBLs-producing strains was identified and its isoelectric point(pI) value was detected by isoelectric focusing (IEF) method. The pI values were used to design the primers for PCR amplification. The amplified DNA sequences were then compared with the GenBank and the ESBL genotypes were confirmed. Results ( 1 ) The positive rate of ESBLs-producing strains of E. coli was 30. 1% (62/209) from Macao and 54. 0% (81/150)from CMU. (2)The genotype of 56 (90. 5% ) β-lactamase(ESBLs)-producing E. cull strains from Macao was CTX-M56. Most of them were CTX-M-14 (76. 2% ), other genotypes including CTX-M-9 (4. 8% ), CTX-M-22 (3.2%), CTX-M-24(3.2%), CTX-M-27(1. 6% ), and CTX-M-15( 1.6% ) were found. Six strains were unidentified. (3)The genotype of 74(91.5% )β-lactamase(ESBLs) -producing E. coli strains from Shenyang was CTX-M. Most of them were CTX-M-14 (65.4%), other genotypes including CTX-M-3 ( 13.6% ), CTX-M-24 (4. 9% ),CTX-M-22(2.5%), CTX-M-15(2.5%), CTX-M-9(1.2%) and CTX-M-28(1.2%) were found. Seven strains were unidentified. Conclusions CTX-M genotypo was the mostly identified ESBL-preducing E. Coli strains from Macao and the results were similar with that from CMU. Among them, the CTX-M-14 was the major genotype. Other genotypes included CTX-M-9, CTX-M-15, CTX-M-22, CTX-M-27, and CTX-M-24.However, two genotypes of CTX-M-3 and CTX-M-28 were not found in the clinical isolates in Macao and one genotype of CTX-M-27 was not found from the CMU clinical isolates.

OBJECTIVE：To evaluate the efficacy and safety of admi nistration of doxazosin mesylate in mild to moderate essential hypertension.METHODS　In the trial,43 patients meeting the creteria of enlistment after 2-week wash-out periods are randomized into two groups in term of double- blind manner,22 cases for doxazosin mesylate group,21 cases for Terazosin hydroc hloride group.The patients will recept the scheduled medication intervention and blood pressure measure in order to assess the efficacy of antihypertension.Phys ical examnation, electrocardiogram,hematological and urinary test will be perfor med for monitoring the adverse events according to the trial protocol.RE SULTS：The rate of effectiveness of doxazosin mesylate for hypertension controling is 86.4%.No severe adverse events such as the cardiovascular disorder s appear in the 6-week trial except for the mild,toleratable headache in one pat ient.Doxazosin mesylate does not interfere with the hepatic and renal metabolism and impair their functions.CONCLUSIONS：Doxazosin mesylate adim inistration is effective and safe in mild to moderate essential hypertension.