Objective To explore the anomalous effects of India buead and coix seed powder on phlegm-dampness constitution dyslipidemia through population-based intervention studies. Methods According to the experimental results of the model group with dyslipidemia, the phlegm-dampness population meeting the inclusion criteria were chosen as the samples for the randomized controlled trial, who were divided into test meal (21 males and 39 females) and blank control (23 males and 37 females) groups with 60 cases in each, aged 18 to 65 y and the total of 120 cases completed the study. Statistical analyses were performed with SPSS 18.0 statistical software. The self comparison wass conducted by the method of paired-sample t test and the comparison between groups was conducted by using independent sample t test. The categorical statistics were described as frequency and compared throughc2 test, P<0.05 was considered as statistically significant. Without changing the original way of life, the meal group having taken the India buead and coix seed powder was compared independently and with the control group for TC, TG, HDL-C and LDL-C to detect the trends and degrees of the level changes. Meanwhile, according to efficacy tests and standards, the changes in the level of TC, TG and HDL-C have been evaluated and the efficiency and total effective rates of all the variables have been calculated. Results After the intervention, there was a declining tendency in each variable, 8.9%in TC, 21.4%in TG, and 27.2%in LDL-C, except for an increase of 0.13 mmol/L in HDL. There were significant differences in the variables before and after the intervention (P<0.05 in each). As for the test meal group after the intervention, the effectiveness of TC has been obtained in 25 cases and inefficacy in 35 cases, with efficiency of 41.7%;the effectiveness of TG has been shown in 53 cases and inefficacy in 7 cases, with efficiency of 88.3%;the effectiveness of HDL-C has been gained in26 cases and inefficacy in 34 cases, with efficiency of 43.3%; and the total effective rate was 57.8%. Conclusions There are significant changes and improvements in TC, TG, HDL-C and LDL-C in the test meal group after the intervention with the powder, which demonstrate that the powder is effective in the reduction of TG for animals with dyslipidemia and populations with phlegm-dampness constitution.

Objective To evaluate 10-year risk of ischemic cardiovascular diseases (ICVD) in middle-aged adults in Henan province to provide evidence for improved health status. Methods The 10- year risk of ICVD in 12 064 middle-aged adults was evaluated by using simplified risk estimation model. Results About 96. 35% of male and 98. 29% of female had a probability of < 10% to develop ICVD over 10 years; 3.65% of male and 1.71% of female had a probability of ≥ 10% to develop ICVD over 10 years; and 0.68% of male and 0.23% of female had a probability of≥20% to develop ICVD over 10 years. The prevalence of risk factors for ICVD in two absolute risk groups ( ≥10% vs < 10% ) was significantly different. Conclusions The risk of ICVD in the middle-aged residents of Henan province may be similar to that in the middle-aged Chinese adults. The risk assessment for ICVD could be used for high- risk populations.

Objective To explore and clarify the clinical features and management of patients with Castleman disease.Methods The clinicopathological features and therapeutic method of 65 patients with Castleman disease admitted to our hospital continuously from 2005 to 2012 were analyzed retrospectively.The mean follow-up time for the entire series was 40 (15-71) months.Results In contrast to Localized Castleman disease(LCD),Multicentric Castleman disease (MCD) patients were relatively older and exhibit various symptoms and abnormal laboratory tests.We found 44 tumor in LCD group.LCD ones,most of which were hyaline vascular (33/42,78.6％),were more likely originated in retroperitoneum,enterocoelia(10/44,22.7％) or mediastinum(10/44,22.7％).The initial treatment for LCD patients was complete surgical resection and all patients are current alive with no evidence of recurrence.MCD ones always accompanied by fever(9/23,39.1％),anemia(9/23,39.1％)and splenomegaly,and most of MCD patients were plasmacytic variants(14/23,60.9％) or mixed cellular variants (5/23,21.7％).We found 66 tumor in MCD group and they were more likely originated in neck (16/66,24.2％) and groin area (12/66,18.2％).Surgery combined with CHOP-like chemotherapy or CHOP-like chemotherapy alone was the mainstream treatment for MCD ones.21 patients achieved complete remission or partial remission,and only 2 patients died of lung infection.Whether patients could tolerate long-term chemotherapy or not was an important prognostic factor.Conclusions LCD patients had no typical clinical symptoms and could be cured by surgery.Most of MCD patients always had a good prognosis after receiving CHOP-like chemotherapy.

Objective To explore the correlation of S100 protein with the prognosis of patients with primary retroperitoneal liposarcoma. Methods Analyzed the clinical data about 108 patients with primary retroperitoneal liposarcoma managed with surgery from January 2009 to June 2014. All patients were followed up. Patients were divided into S100-positive group(58 patients) and S100-negative group (50 patients) according to the immunohistochemical staining results. The overall survival time and all clinical data between two group were compared. Results All patients with primary retroperitoneal liposarcoma received radical surgical resection for the first time. The overall 5-year recurrence rate were 88.9%(96/108), and the median recurrence time was 32.7 months. The 1-year, 2-year, and 5-year recurrence rates of the S100- positive group were 25.9% (15/58), 53.4% (31/58), 96.6% (56/58), respectively, and the median recurrence time were 26.2 mouths. The 1-year, 2-year, and 5-year recurrence rates of the S100-negative group were 10.0%(5/50), 36%(18/50), 80.0%(40/50) and the median recurrence time were 40.0 mouths. Log-rank test showed that S100 protein expression was significantly associated with postoperative recurrence rates (c2=9.931, P=0.002) and survival time (c2=4.571, P = 0.033). The difference between gender, age, removal of the joint organs and tumor size showed no statistical significance on disease special survival (P>0.05). Cox regression analysis showed that S100 protein expression (OR=1.582, 95%CI:1.005-2.491) and histologic subtype (OR=1.531, 95%CI: 1.254-1.870) were independent risk factors of the prognosis of primary retroperitoneal liposarcoma patients. Conclusions S100 protein played a critical role in retroperitoneal liposarcoma carcinogenesis and its expression may be used as a potential survival predictor in patients with primary retroperitoneal liposarcoma.

Primary retroperitoneal liposarcoma is a rare low-grade malignant tumor and accounts for approximately 1% of all adult malignancies. Complete gross resection is the most important and maybe only method to cure retroperitoneal liposarcoma. The addition of advanced- modality radiotherapy to surgery for primary retroperitoneal liposarcoma is associated with improved local recurrence-free survival, and the toxic effect is tolerable. Several new drugs, especially targeted drugs, have achieved good efficacy. The aim of this article is to improve the understanding of treatment of primary retroperitoneal liposarcoma. The multidisciplinary therapy model, including surgery, radiotherapy, chemotherapy and targeted therapy, is recommended for patients with retroperitoneal liposarcoma.

Objective Increasing evidence suggest that aberrant activation of PI3K/Akt is involved in many human cancers, and that inhibition of the PI3K/Akt pathway might be a promising strategy for cancer therapy. The study is to evaluate the effects of combined therapy of PI3K inhibitor (LY294002) and Ad-PTEN in athymic mice xenogeneic transplant model of human glioma and to reveal the possible mechanisms involved.Methods Twenty-four athymic mice were randomly divided into 4 groups (DMSO、Ad-vector plus DMSO、LY294002 alone and Ad-PTEN plus LY294002), and were treated, respectively. Athymic mice xenogeneic transplant model was established by inoculation (sc) with LN229 glioma cells. Body mass (BM) and diameter of tumor mass were measured. Furthermore, The protein expressions of PTEN、p-Akt、CyclinD1、Caspase-3、MMP-2、p-FAK in tumor tissues were analyzed with immunohistochemistry.Results The tumor-inhibiting rate of was significantly higher in Ad-PTEN plus LY294002 than in the LY294002 alone (92.46 vs 65.59%)( P <0.05).The protein expressions of PTEN and Caspase-3 were significantly higher, while PCNA、CyclinD1、bcl-2 and MMP-2、p-FAK was significantly lower in Ad-PTEN plus LY294002 group than in the other three groups ( P <0.05).Conclusions LY294002 plus Ad-PTEN achieve better outcome than either alone in treating glioma possibly through enhancement of the inhibitory action of PI3K/Akt pathway and Ad-PTEN pathway.

Objective: To understand the environmental sanitation situation of rural schools in different geographical areas of Shaanxi, and to provide scientific basis for improving hygiene and sanitation in Chinese rural schools. Methods: Each year during 2016 to 2018, 150 townships in 30 counties of rural areas were randomly selected in various districts and cities throughout the province. In each township one junior high school and one elementary school were randomly selected, and the data was obtained through resource access, interviews, and on-site observations. The data was statistically analyzed and evaluated according to the northern, central and southern regions. Results: The differences of drinking ways among students in the schools were of statistical significance(χ2=25.89,P<0.01). The major drinking water method of students in the monitoring schools of the three regions all was providing boiled water, accounting for 56.16%, 65.88%, 50.39%, all of which have direct drinking unboiled water phenomenon; The water supply method of the self-provided centralized water supply school is mainly precipitation filtration in the central and southern regions, accounting for 38.46%, 53.21%, and untreated in the northern region(60.61%); The differences of the proportions of having sanitary toilets, detached toilets in schools, having toilets in teaching buildings, and having toilets in dormitory buildings in three regions were of statistical significance(χ2=32.04, 12.73, 20.78, 33.11, P<0.01) The proportion of schools with squat toilets in men’s toilets was greater than that of women’s(χ2=86.53, 44.77, 21.88, P<0.01). The differences of the proportion of schools with faucets available in toilets and within 5 meters around toilets, with sinks in or around the toilets, with sinks equipped with soap in or around the toilets were of statistical significance(χ2=90.02, 10.40, 41.96, P<0.01). Conclusion During 2016 to 2018, the environment sanitation of the three major rural primary and middle schools in Shaanxi Province needs to improve corresponding supporting facilities, and increase publicity to improve teachers and students’ awareness of health and safety.

Objective To compare the fascia iliaca compartment block versus femoral nerve 3-in-1 block for postoperative analgesia in elderly patients undergoing hip surgery.Methods A total of 160 patients with hip fracture,of American Society of Anesthesiologists physical status Ⅱ or Ⅲ,aged 70-101 yr,weighing 30-93 kg,scheduled for elective total hip replacement or artificial femoral head replacement under general anesthesia,were divided into 2 groups (n =80 each) using a random number table:fascia iliaca compartment block group (FIB group) and femoral nerve 3-in-1 block group (FNB group).Ultrasound-guided fascia iliaca compartment and 3-in-1 blocks were performed with 0.2％ ropivacaine 40 ml in FIB and FNB groups,respectively.Patient-controlled analgesia (PCA) with 0.2％ ropivacaine 275 ml was used for postoperative analgesia until 72 h after operation in both groups.The PCA pump was set up with a 5 ml bolus dose,a 60 min lockout interval and background infusion at a rate of 5 ml/h,and the visual analog scale score was maintained≤4.When the visual analog scale score＞4,tramadol 50-100 mg was taken orally or injected intramuscularly for rescue analgesia.Before implanting the catheter,at 15 min after the initial administration and at 12 h after operation,temperature sensation and light touch sensation tests were performed in the anterior regions of thigh (innervated by femoral nerve),lateral region of thigh (innervated by lateral femoral cutaneous nerve) and superior part of the anterior region of thigh (innervated by obturator nerve).Successful sensory block was defined as the occurrence of a decline in temperature sensation or in light touch sensation in any area,and the successful sensory block was recorded.The requirement for rescue analgesia and patient's satisfaction with analgesia were recorded within 72 h after operation.The development of adverse reactions such as nerve damage,nausea and vomiting,dizziness and palpitation was also recorded within 48 h after operation.Results Compared with group FIB,the rate of successful analgesia in lateral thigh area was significantly decreased at 15 min after the initial adminstration and 12 h after operation,the requirement for rescue analgesia after operation was increased,the rate of satisfactory analgesia after operation was decreased (P＜0.05),and no significant change was found in the incidence of postoperative nausea and vomiting or dizziness in group FNB (P＞0.05).Conclusion Ultrasound-guided continuous fascia iliaca compartment block provides better efficacy for postoperative analgesia than 3-in-1 block in elderly patients undergoing hip surgery.

Objective:To investigate the effect of Clostridium perfringens combined with live bacteria therapy on intestinal flora, inflammation and immune indicators in children with pneumonia and antibiotic associated diarrhea.Methods:From December 2016 to October 2019, 44 neonates with pneumonia and antibiotic associated diarrhea diagnosed and treated in the Sixth People's Hospital of Datong were selected in the study, and they were divided into control group and observation group according to the random number table method, with 22 cases in each group.On the basis of routine symptomatic treatment, the control group was treated by oral administration of Saccharomyces boulardii, and the observation group was treated with Clostridium perfringens combined with live bacteria powder.The treatment course was two weeks.The intestinal flora, inflammatory factors and immune function of the two groups were compared.Results:There were no statistically significant differences in the levels of IL-2, IL-6 and TNF-α between the two groups before treatment(all P>0.05), and the levels of IL-2, IL-6 and TNF-α in the two groups after treatment were significantly improved(all P<0.05). The levels of IL-2[(34.20±8.55)ng/L vs.(40.13±10.32)ng/L], IL-6[(21.02±5.66)ng/L vs.(31.25±7.82)ng/L] and TNF-α[(30.10±6.20)ng/L vs.(43.55±9.52)ng/L] in the observation group were significantly lower than those in the control group( t=7.501, 6.885, 8.264, all P<0.05). There were no statistically significant differences in the number of Lactobacillus, Bifidobacterium and Eubacterium in the two groups before treatmentt(all P>0.05), and the number of Lactobacillus, Bifidobacterium and Eubacterium in the two groups after treatment increased significantly(all P<0.05). The number of Lactobacillus[(9.50±0.53)×10 8 CFU/mL vs.(8.95±0.44)×10 8 CFU/mL], Bifidobacterium[(10.60±0.53)×10 8 CFU/mL vs.(9.90±0.46)×10 8 CFU/mL] and Eubacterium[(8.93±0.68)×10 8 CFU/mL vs.(8.08±0.40)×10 8 CFU/mL] in the observation group were significantly higher than those in the control group( t=5.065, 6.547, 5.116, all P<0.05). There were no statistically significant differences in the levels of CD 3+ , CD 4+ , CD 8+ and CD 4+ /CD 8+ between the two groups before treatment(all P>0.05), and the levels of CD 3+ , CD 4+ , CD 8+ and CD 4+ /CD 8+ in the two groups after treatment were significantly improved(all P<0.05). The levels of CD 3+ [(62.55±5.06)% vs.(57.12±4.39)%], CD 4+ [(40.52±3.52)% vs.(36.43±2.55)%], CD 4+ /CD 8+ [(1.78±0.22) vs.(1.43±0.13)] in the observation group were significantly higher than those in the control group( t=7.504, 6.958, 5.452, all P<0.05). The level of CD 8+ [(21.22±2.05)% vs.(25.44±2.49)%] in the observation group was significantly lower than that in the control group( t=5.112, P<0.05). Conclusion:Clostridium perfringens combined with live bacteria in the treatment of neonatal pneumonia with antibiotic associated diarrhea can improve intestinal flora, reduce inflammatory response and improve immune function, and the effect is better.

Objective: To investigate and analyze the drinking water quality among rural primary and secondary schools in Guanzhong area in 2018, and to provide a basis for the targeted improvement of water supply facilities. Methods: Develop a questionnaire on the basic situation of centralized water supply in rural schools, according to the Standard Test Method for Drinking Water (GB/T 5750—2006) and the Sanitary Standard for Drinking Water (GB 5749—2006) for the rural school network in Guanzhong area. The peripheral water collection and testing carried out single factor and multifactor statistical analysis on the relationship between water quality influencing factors and water quality pass rate. Results: The total qualified rate of drinking water quality in rural schools in Guanzhong area was 59.1%. Univariate analysis showed that water quality rate was affected by four factors including water source type, engineering type, sanitation permit and disinfection equipment use, and the difference was statistically significant(P<0.05). Unconditional two-class logistic regression analysis showed that disinfection (OR=3.14), engineering type (OR=2.05), and sanitation permit (OR=1.99)(P<0.05) affected the water quality pass rate. Conclusion It is recommended to further strengthen the investment in the renovation of water supply for rural schools in Guanzhong area, and specifically strengthen water supply treatment and standard disinfection.