Objective To investigate the therapeutic effect of transcatheter arterial chemoembolization(TACE) combined with CT-guided percutaneous radiofrequency ablation(PRFA) in treating advanced primary hepatocellular carcinoma.Methods 40 cases with advanced primary hepatocellular carcinoma were randomly divided into TECA group(n=20) and TACE and PRFA group(n=20).Results The complete necrosis rate of tumor,the recurrence rate and one-year survival rate were 22.5%(9/40),37.5%(15/40) and 75.0%(30/40),respectively in TACE group and 90.0%(36/40),12.5%(5/40) and 90.0%(36/40),respectively in TACE and PRFA group.There were significant statistical differences between the two groups(P value were 0.002,0.002 and 0.008,respectively).Conclusion The therapeutic effects of TACE combined with CT-guided PRFA show better results than that of TACE alone.