Objective To explore the influence of early perinatal health care for the pregnancy outcome of gestational diabetes mellitus (GDM).Methods 86 cases of GDM patients who received obstetrical examination and parturition were randomly divided into the two groups by random number table.The control group (n =43) was given traditional health education,and the observation group (n =43) was given early perinatal health care including diet control,proper exercise,mental health and drug therapy.The blood sugar control situation and pregnancy outcome between the two groups were compared and analyzed.Results The fasting blood glucose and 2 hour post-meal blood sugar in the observation group were (5.07 ± 0.73) ％,(4.47 ± 0.29) mmol/L,(6.84 ± 1.31) mmol/L,(1.11 ±0.32) mg/L,which were significant lower than those of the control group [(5.07 ± 0.73) ％,(5.31 ± 0.64) mmol/L,(8.45 ± 1.37) mmol/L,(1.76 ± 0.44) mg/L] (t =5.38,6.91,7.81,3.45,all P ＜ 0.05).The incidence of preeclampsia,cesarean section,postpartum hemorrhage in the observation group were 5.0％,20.0％,7.5％,significant lower than those of the control group(22.5％,57.5％,30.0％) (x2 =5.16,11.85,6.65,all P ＜ 0.05).Compared with the control group,the complication of premature delivery,fetal macrosomia,neonatal hypoglycemia for perinatal infant in the observation group were significantly reduced (x2 =3.91,4.50,4.02,all P ＜ 0.05).Conclusion GDM is correlated with pregnancy outcome,strengthening early perinatal care can effectively reduce the mother infant complications and improve the perinatal prognosis.