Objective To study the clinical value of the platelet count (PC),fibrinogen (Fib) and D-dimer detection in patients with cervical cancer.Methods Eighty-seven patients with cervical cancer (cervical cancer group) and 66 patients with cervical benign lesion (control group) were selected,the levels of PC,Fib and D-dimer were respectively determined to analyze the clinical significance of three factors.Results The PC,Fib and D-dimer in cervical cancer group were significantly higher than those in control group [(274.22 ± 82.32) × 109/L vs.(238.82 ±74.97) × 109/L,(3.03 ±0.59) g/L vs.(2.67 ±0.45) g/L,(182.77 ± 167.07) ng/L vs.(113.74 ± 64.84) ng/L,P ＜ 0.05].Patients with stage Ⅱ and tumor volume ＞ 4 cm were obviously higher than patients with stage Ⅰ and tumor volume ≤ 4 cm in the PC,Fib and D-dimer [(296.66 ±94.30) × 109/L vs.(251.26 ±60.86) × 109/L,(3.22 ±0.67) g/L vs.(2.84 ±0.42) g/L,(238.61 ± 213.29) ng/L vs.(125.63 ± 62.96) ng/L,(299.14 ± 81.33) × 109/L vs.(257.44 ± 79.39) ×109/L,(3.20±0.67) g/Lvs.(2.91 ±0.50) g/L,(281.29 ±223.33) ng/L vs.(116.46 ±51.69) ng/L,P＜0.05].But there was no significant difference between lymph node metastasis positive patients and lymph node metastasis negative patients (P ＞ 0.05).Conclusion The PC,Fib and D-dimer of patients with cervical cancer are helpful to clinical cervical cancer diagnosis,treatment and prognosis improvement.

Objective To explore the short-term prognosis of tirofiban hydrochloride on the patients with acute ST-segment elevation myocardial infarction and the influence of tirofiban hydrochloride on myocardial biomarkers. Methods 334 patients with acute ST-segment elevation myocardial infarction were choosen. They were divided into two groups, 167 cases in each group. Tirofiban hydrochloride was used in the experimental group, and conventional therapy was carried out for control group. Compared the biochemical indexes, myocardial biomarkers and cardiac function of the two groups. Results The effective rate of experimental group was 165 cases (98.80%), which was higher than 150 cases (89.82%) in the control group (χ2=12.556,P<0.05). After treatment, the cardiac troponin I (cTnI) in experimental group was lower than control group (P<0.05). The levels of left ventricular end diastolic volume (LVEDV) and left ventricular endsystolic volume (LVESV) significantly decreased and the level of left ventricular ejection fraction (LVEF) increased in experimental group compared with those in control group(P<0.05).The global registry of acute coronary events (GRACE) after treatment in experimental group was lower than that in control group (P<0.05). The hyporrhea of thrombolysis in myocardial infarction (TIMI) in experimental group were 5 cases (2.99%), which was lower than 19 cases (11.38%) in control group (χ2=8.799,P<0.05). After 12 months, the attack frequency of angina in experimental group was (1.78±0.78)times, which was lower than (2.56±1.04) times in control group (P<0.05). Conclusion Patients with acute ST-segment elevation myocardial infarction should be diagnosed as soon as possible and take treatment strategies according to individual situation to chose suitable dosage of tirofiban hydrochloride for good therapeutic effect.

Objective To explore the methods and mesures for the pre-analytical quality control of test specimen and to improve the accuracy and reliability of test results.Methods According to the relevant requirements of IS015189,various measures for the specimen circulation process and collection technology two aspects were taken to control the full links of clinical specimen collection and transport,and the incidence of unqualified specimen before and after the improvements were analyzed.Results After the imple-mentation of the improvement measures,the incidence of unqualified specimens was decreased significantly.Conclusion Implemen-tation of the whole aspect of pre-analytical quality control can effectively improve the quality of specimen in order to improve the test quality.

Introduction: Derangement in calcium homeostasis is common in nephrotic syndrome (NS). It is postulated that low serum total calcium and vitamin D levels are due to loss of protein-bound calcium and vitamin D. It is unclear if free calcium and free vitamin D levels are truly low. The guideline is lacking with regards to calcium and vitamin D supplementation in NS. This study aims to examine calcium and vitamin D homeostasis and bone turnover in NS to guide practice in calcium and vitamin D levels supplementation. Methodology: This is a prospective pilot study of ten patients diagnosed with NS, and eight healthy controls. Calcium, vitamin D, and bone turnover-related analytes were assessed at baseline, partial and complete remission in NS patients and in healthy controls. Results: NS patients had low free and total serum calcium, low total 25(OH)D, normal total 1,25(OH)D levels and lack of parathyroid hormone response. With remission of disease, serum calcium and vitamin D metabolites improved. However, nephrotic patients who do not attain complete disease remission continue to have low 25(OH)D level. Conclusion In this study, the vitamin D and calcium derangement observed at nephrotic syndrome presentation trended towards normalisation in remission. This suggested calcium and vitamin D replacement may not be indicated in early-phase nephrotic syndrome but may be considered in prolonged nephrotic syndrome.
Vitamin D Deficiency