Objective To analyze the clinical and laboratory characteristics of systemic lupus erythematosus (SLE) in children. Methods Fifty-three inpatients, 5 boys and 48 girls with SLE, who aged from 7 to 14 years with a median age at 12 years, were enrolled into this study. A retrospective study was carried out to assess the clinical and laboratory features of these pediatric patients. Results The ratio of male to female patients was 1:9.6. Skin eruption was the most common initial manifestation (41.51%), followed by fever (20.75%) and arthralgia (20.75%). Systemic involvement was common, and 84.90% of these patients had hematological abnormalities, 60.38% renal involvement, 18.87% nervous involvement. The most common manifestation of hematological, renal and nervous involvement was anemia, proteinuria and seizures, respectively. Among the immunologic parameters tested, anti-nuclear antibody showed the highest positivity rate of 90.57%, followed by anti-dsDNA with a positivity rate of 67.92%. There was no significant difference between the male and female patients in the age of onset, SLEDAI score at admission and discharge, duration of hospitalization or the dose of corticosteroid used initially and at the discharge. Conclusion The manifestations of pediatric SLE are various, and multisystem involvement is common in these patients. Early diagnosis and active treatment might benefit the prognosis of pediatric SLE.

Through the analysis of the current drug testing market, this paper discussion the meeting of creating "Drug Testing in China" brand on the concept of scientific testing.
China ; Drug Industry ; organization & administration ; Pharmaceutical Preparations ; Pharmaceutical Services ; organization & administration ; Quality Control

This paper discussed the building of post market risk analysis method in hemodialysis device from the point of government supervision. By proposing practical research methods for post market risk identification and estimation on hemodialysis device, providing technical guidance for government to put risk management of hemodialysis device into effect, and offering reference for enterprises to carry out post market risk evaluation on their products as well.
Government Regulation ; Renal Dialysis ; instrumentation ; standards ; Research Design ; Risk Assessment ; Risk Management

First, simply expounded the purpose and meaning of detecting tungsten extracted from prefi lable syringes: And then, designed simulation experiment for extracting tungsten from prefi lable glass syringes. and established determination methods of tungsten content by ICP-MSL Finaly, evaluated the limit of content of tungsten ?extracting from simulation experiment.

This paper discussed the building of post market risk analysis method in hemodialysis device from the point of government supervision. By proposing practical research methods for post market risk identification and estimation on hemodialysis device, providing technical guidance for government to put risk management of hemodialysis device into effect, and offering reference for enterprises to carry out post market risk evaluation on their products as wel.

Objective To explore the effect of cognitive thinking rehabilitation nursing on the delayed encephalopathy after acute CO intoxication .Methods From October 2012 to May 2013 , totals of 37 cases with delayed encephalopathy after acute CO intoxication were selected as study group , and others 33 cases during November 2013 and May 2014 were recruited as control group .Study group received the rehabilitation nursing of cognitive thinking on the basis of routine nursing , while control group received the routine nursing only .Then, the clinical effect of two groups were observed .Results After the intervention , the scores of MMSE , HDS and ADL in study group were (16.87 ±3.95),(18.90 ±3.65) and (42.12 ±10.21),that respectively higher than before the intervention (25.04 ±2.00),(26.04 ±1.71) and (86.12 ±8.93),and the differences were statistically significant (P<0.05).In control group, scores of MMSE [(21.05 ±1.75) vs (16.86 ±3.92)], HDS[(20.97 ±1.65) vs (18.06 ±3.70)] and ADL[(65.52 ±10.38) vs (43.01 ±11.23)] after the intervention were higher than that before , and the differences were statistically significant (P<0.05).After the intervention , the scores of MMSE , HDS and ADL in study group were significantly higher than that in control group (t=3.449,6.747,4.758,respectively;P<0.05),and the nursing satisfaction of patients in study group was significantly higher than that in control group (97.30% vs 87.88%;χ2 =2.333, P <0.05). Conclusions Strengthen the rehabilitation nursing intervention of cognitive thinking can improve cognitive and self-care abilities of patients with delayed encephalopathy after acute CO intoxication , and improve patients ’ satisfaction,which is worthy of clinical popularization and application .